Py-Im polyamides
Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides
... Pyrrole-imidazole polyamides are a class of synthetic ligands that can be programmed to bind the minor groove of specific DNA ...whereas Py/Py pairs are specific for both T·A and ...hairpin ...
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Activity of Py Im Polyamides in Anti Androgen Resistant Prostate Cancer Models
... (Py-Im) polyamides are non-covalent, sequence specific DNA binders that can alter DNA ...of Py-Im polyamides, these molecules are cell permeable and localize to the cell nucleus ...
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Synthesis and Structural Studies of Cyclic Py Im Polyamides
... the polyamides in this study provide a large thermal stabilization to DNA as opposed to RNA, which does not have an increased melting temperature for any of the compounds ...
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Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides
... we have used melting temperature analysis for dissecting differences in DNA affinities of hairpin polyamides. Spectroscopic analyses were performed on 12mer DNA duplexes containing the appropriate match sequence ...
209
Targeting DNA Repeat Sequences with Py Im Polyamides
... The inability of the γ-amino GABA turn to enforce forward orientation binding led us to investigate alternative solutions for the molecular recognition of 5′-CGCG-3′. We posited that reverse binding is abetted by the ...
143
Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist
... Py-Im polyamides are programmable small molecules capable of binding to DNA with affinities and specificities comparable to DNA-binding proteins ...groove: Im/Py specifies a G-C base pair, ...
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Biological Activity of Pyrrole-Imidazole Polyamides in vivo
... Hairpin Py-Im polyamides have been used to regulate gene expression in tissue ...that Py-Im polyamides are capable of displacing transcription factors in gel shift assays (9, 10, ...
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Antitumor Activity of Py-lm Polyamides
... of Py-Im polyamides as non- genotoxic antitumor agents that are active against prostate cancer ...hairpin polyamides targeted to the 5’-WGWWCW-3’ sequence found in the androgen response ...4 ...
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Improving the Biological Activity of Pyrrole-Imidazole Polyamides
... Cyclic Py-Im polyamides containing two GABA turn units exhibit enhanced DNA binding affinity, but extensive studies of their biological properties have been hindered due to synthetic ...cyclic ...
211
Effect of Acidic Catalyst on Properties of Novel Conductive Copolymer Films Made of Pyrrole and Formyl Pyrrole
... Effect of acidic catalysis having carboxylic acid group was studied on properties of conductive copolymer films made of pyrrole (Py) and 2-formyl pyrrole (FPy). It was noted that trifluoroacetic acid (TFA) and ...
7
(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling
... bind pY-containing peptides with much stronger affinity than natural SH2 domains or traditional anti-pY antibody (4G10) [11, ...diverse pY sites to block related signal transduction pathways, can ...
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ALLELIC COMPLEMENTATION AT THE PYRIMIDINE (py) LOCUS OF THE CRUCIFER, ARABIDOPSIS
... This paper is concerned with complementation among alleles affecting nutrition and synthesis in temperature-sensitive mutants of the higher plant, Arabidopsis.. The temperature- sen[r] ...
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langid py: An Off the shelf Language Identification Tool
... Despite the recently published results on language identification of microblog messages, there is no dedicated off-the-shelf system to perform the task. We thus examine the accuracy and performance of using generic ...
6
Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.
... of Py to 25,000 sialylated receptors on unmodified 3T6 ...of Py infection by the modified sialic acids is medi- ated by a reduction in virus-receptor interaction, binding as- says using purified virus ...
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E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.
... Adenovirus ElA proteins repress transcriptional activation of various enhancers, including those of Py, and can stimulate DNA replication in quiescent cells, but ElA effects on Py DNA re[r] ...
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Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.
... bovine Py (which does not show much homology in its central palindrome) all contain the ACTACTT (ACT) sequence, as well as homologous A/T regions and cen- tral palindromes (21, 51, 52), which is unwound by SV40 T ...
7
The Demand for Current Public Expenditure in Fiji: Theory and Empirical Results
... Economic/structural and institutional explanatory variables applied in the real demand for government expenditure G in Iran Variable name Economic/Structural Pg Py Pg/Py PERY POP INDUEMR[r] ...
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Synthesis and Characterization of Novel Photoactive Poly(ether-amide)s Based on Highly Substituted Phenanthrimidazole
... of polyamides, and this has included the introduction of noncoplanar groups, incorporation of unsymmetrical structure, and the introduction of bulky side groups into the polymer ...
8
Programming Protein Patterns on DNA Nanostructures with Pyrrole Imidazole Polyamides
... linked polyamides can target sequences up to 10 bp in ...eight-ring polyamides due to their larger ...link polyamides once they are bound in close proximity in the minor-groove of ...
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Interaction of nuclear factor EF-1A with the polyomavirus enhancer region.
... EF-1A binding to Py site 1 is independent of cooperation with other EF-1A sites or the adjacent binding sites for PEA-1 and PEA-2, two murine nuclear factors that bind in the Py A enhanc[r] ...
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