pyruvate kinase (E.C. 2.7.1.40)
Evaluation of tumor M2 pyruvate kinase (Tumor M2 PK) as a biomarker for pancreatic cancer
... of pyruvate kinase [1 – ...M2- pyruvate kinase as a diagnostic test for pancreatic cancer ...M2-pyruvate kinase had an area under the curve (AUC) of ...
6
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
... type 2 transglutaminase (TG2), which accumulates under stressful cell conditions, plays an important role in the regulation of autophagy and cells lacking this enzyme display impaired autophagy/mitophagy and a ...
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Pyruvate kinase is necessary for Brucella abortus full virulence in BALB/c mouse
... Brucellosis, caused by a facultative intracellular pathogen Brucella, is one of the most prevalent zoonosis worldwide. Host infection relies on several uncanonical virulence factors. A recent research hotpot is the links ...
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The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
... type 2 transglutaminase (TG2), which accumulates under stressful cell conditions, plays an important role in the regulation of autophagy and cells lacking this enzyme display impaired autophagy/mitophagy and a ...
14
Pyruvate kinase and the "high ATP syndrome"
... The pyruvate kinase activity was specifically increased (about twice the normal ...the pyruvate kinase activity was found to be increased in all Percoll ...fractions. Pyruvate ...
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Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L )
... reported in mussels collected from other sites of Thermaikos Gulf (unpublished results from our laboratory). The site of mussel sampling is a less polluted site in an ecosystem with low levels of cadmium contamination, ...
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A study on pyruvate kinase from carcinus maenas
... S.cerevisae enzyme forms an enzyme-pyruvate complex MacFarlane and Ainsworth, 1972 whilst the rabbit muscle enzyme Ainsworth and Macf'arlane, 1973 and the C.maenas enzyme both form enzym[r] ...
268
Trojans in Wireless Sensor Networks
... employed Pyruvate kinase synergetic co-activator ...reasons: 1) FBP easily dissociates from PKM2/FBP complex and is excreted by kidney or absorbed by tissues in vivo; 2) PKM2 could be modified ...
209
Activities of key glycolytic enzymes in the plasma of Saudi autistic patients
... Table 2 demonstrates the activity levels of lactate oxidase, hexokinase, and pyruvate kinase are three critically important glycolytic enzymes to monitor in Saudi autistic children as compared to the ...
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Nutritional regulation and tissue specificity of gene expression for proteins involved in hepatic glucose metabolism in rainbow trout (Oncorhynchus mykiss)
... (6PF-2K/F-2,6BPase), pyruvate kinase (PK), fructose-1,6-bisphosphatase (FBPase) and glucose transporter type 2 (Glut2) gene expression in food- deprived rainbow trout and fed rainbow trout with 20 % ...
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Regulation of hepatic gluconeogenesis and glycogenolysis by catecholamines in rainbow trout during environmental hypoxia
... A Liver pyruvate kinase activity for series I at 0-2 and 5-0mmoll ' phosphoenolpyruvate PEP concentrations and the ratio of activities at 0-2/5-OPEP and B glycogen phosphorylase activity[r] ...
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Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease
... The progressive decline in cerebral glucose utilization is known to occur with age and in AD, possibly contributing to both nerve cell loss and memory decline (Heiss et al., 1991; Mielke et al., 1998). Reductions in ...
206
Warburg effect hypothesis in autism Spectrum disorders
... into pyruvate is the final step in glycolysis after glucose entered the ...enzyme pyruvate kinase (PK) catalyzes this ...isomerase 1 (Pin1) [103], which reduces its activity and targets PKM2 ...
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RED CELL METABOLISM IN THE NEWBORN INFANT. V. GLYCOLYTIC INTERMEDIATES AND GLYCOLYTIC ENZYMES
... (p <0.001) hexokinase, phosphoglucose isomerase, phospiiofructo- kinase, aldolase, phosphogluconlutase, pyruvate kinase, and glucose-6-phosphate dehydrogenase (all higher in reticuloc[r] ...
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Complex role of HIF in cancer: the known, the unknown, and the unexpected
... Figure 2 Role of hypoxia-inducible factor 1 (HiF-1) in regulating bioenergetics and biosynthesis through the induction of pyruvate kinase M2 (PKM2) in proliferating cancer ...with ...
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Nonmetabolic functions of metabolic enzymes in cancer development
... as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase-A (KHK-A), hexokinases (HK), nucleoside diphosphate kinase (NDPK or NDK), and ...
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The regulation of some glycolytic enzymes in streptococcus lactis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, New Zealand
... substrat e s whereas phot ograph F shows the trace obtained when the enzyme was not pre-incuba ted with FDP before mixing ...rat e s observed in the s e two cases were very s imilar , and furthermore ...
271
Tribute to P L Lutz: putting life on `pause' – molecular regulation of hypometabolism
... We have recently begun to assess the role of another type of chaperone in hypometabolic states. These are the endoplasmic reticulum (ER) resident chaperones, in particular the glucose- regulated protein, GRP78. We ...
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Phosphorylation of varicella-zoster virus glycoprotein gpI by mammalian casein kinase II and casein kinase I.
... Lanes: 1, 4, and 7, immunoprecipitates added to protein kinase assays with no exogenous source of phosphotransferase activity; 2, 5, and 8, immunoprecipitates added to kinase assays with[r] ...
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Molecular docking studies of (4Z, 12Z) cyclopentadeca 4, 12 dienone from Grewia hirsuta with some targets related to type 2 diabetes
... Glucokinase (GK) is expressed in various organs and plays a key role in hepatic glucose metabolism and pancreatic insulin secretion. GK could indeed serve as pacemaker of glycolysis and could be an attractive target for ...
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