randomized trials in oncology
Discrepancies in endpoints between clinical trial protocols and clinical trial registration in randomized trials in oncology
... trial reporting are determined by recommendations from the ICMJE, which designates minimum criteria required of each registered trial including that the registry must be accessible to the public, open to all prospective ...
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A review of perspectives on the use of randomization in phase II oncology trials
... that randomized trials can be more complex for patients to understand, and that it may be difficult to find patients willing to be randomized ...conducted randomized phase II studies had ...
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OVERVIEW OF RANDOMIZED CONTROLLED TRIALS
... Most randomized trials allocate equal numbers of patients to experimental and control groups. This is the most statistically efficient randomization ratio as it maximizes statistical power for a given total ...
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Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation 2 (STOPIT 2)
... for trials (derived empirically from past trials in other areas – we will review such exist- ing reviews [11-13]) and combine this information with the data from the tRCT to obtain a posterior estimate of ...
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A process for Decision making after Pilot and feasibility Trials (ADePT): development following a feasibility study of a complex intervention for pelvic organ prolapse
... This feasibility and pilot study successfully gained know- ledge about the process and implementation of the pro- posed main trial. It has also identified the gaps in our knowledge that require to be filled prior to ...
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PubMedCentral-PMC4999002.pdf
... Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland (A.K.L, C.M.); American Kennel Club Canine Health Foundation, Raleigh, North Carolina (D.E.B); Department of ...
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Missing trial data briefing notes.
... Tamiflu trials, while there are brief summaries available in the public domain, these do not contain sufficient information to make an informed judgement about the reliability of the trials, and whether ...
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Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
... In addition, identifying a maximum tolerated dose (MTD) might prove less relevant in selecting the recom- mended Phase 2 dose of an ITA. At this writing, determin- ing the minimum effective dose, the maximum effective ...
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Evidence for handheld electronic medical records in improving care: a systematic review
... Articles describing randomized trials or systematic reviews of randomized trials were included. We included studies if 1) we were able to extract relevant data, 2) they included an ...
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Interpersonal psychotherapy for eating disorders: current perspectives
... RCT, randomized controlled trial; RSe, Rosemberg Self-esteem and Social Functioning; SAS, Social Adjustment Scale; SCL-90, Symptom Checklist-90; SOC, State of Change Scale; STAiC, State-Trait Anxiety inventory for ...
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Pre pregnancy care for women with pre gestational diabetes mellitus : a systematic review and meta analysis
... The Newcastle Ottawa Scale (NOS) was used for the as- sessment of cohort, case control studies and non- randomized trials [10]. Risk of bias in each study, was assigned according to the number of items on ...
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Clinical significance in pediatric oncology randomized controlled treatment trials: a systematic review
... non-inferiority trials, representing a small ...non-inferiority trials in this research not be over-interpreted or generalized to the superiority ...
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The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta analysis
... There are several limitations of this systematic review that relate to the primary data. First, the small number of trials and patients enrolled is an important limitation of the data. Second, there were ...
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The effect of benzodiazepines on insomnia in patients with chronic obstructive pulmonary disease: a meta-analysis of treatment efficacy and safety
... few trials were included, and these trials had small sample ...the trials had mild and moderate COPD, and few had a severe status of pulmonary ...
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Combined application versus topical and intravenous application of tranexamic acid following primary total hip arthroplasty: a meta analysis
... 1) Randomized controlled trials or retro- spective control trials; 2) The study compared the efficacy and safety of combined application versus top- ical or intravenous application of tranexamic acid ...
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Guidelines for data and safety monitoring for clinical trials not requiring traditional data monitoring committees
... II trials, there may be one or two members from the NIAID ...all trials in those ...of trials and the availability of independent investigators in the scientific ...many trials reviews are ...
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The Necessity of Randomized Clinical Trials
... clinical trials can also hinder that such trials are ...regarding randomized clinical ...conducting randomized clinical trials ...Clinical Trials Units Network [67], and The ...
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Organizational interventions to implement improvements in patient care: a structured review of reviews
... 39 randomized trials focused on professional performance and 11 randomized trials on patient outcomes ...eight trials, which suggested that documentation was improved but that process ...
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Randomized Trials in Children With UTI
... review of 40 trials published between 1990 and 2016 involving 4381 UTI cases. They highlight the numerous inconsistencies in inclusion criteria and choice of end points in published UTI antibiotic trials ...
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Translating clinical trials from human to veterinary oncology and back
... Of course companies mainly support trials that fit into their own drug development program for a given indica- tion [16], so they review carefully what and how much they will support. Generally, such collaboration ...
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