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RAS/MAPK

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action

... conserved RAS-mitogen activated protein kinase (MAPK) signaling pathway is involved in a wide range of cellular processes including differentiation, proliferation, and ...encoding RAS-MAPK ...

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Fgfr Ras MAPK signaling is required for apical constriction via apical positioning of Rho associated kinase during mechanosensory organ formation

Fgfr Ras MAPK signaling is required for apical constriction via apical positioning of Rho associated kinase during mechanosensory organ formation

... Fig. 4. Ras-MAPK signaling mediates cell-autonomous apical constriction and Rock2a localization. (A,B)  claudinB:EGFP-positive mosaic zebrafish embryos containing hsp70:dn-Ras donor cells (red) at ...

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The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

... (Figure 1B). However, it is unlikely that only the differences in growth rates in vitro translates to the robust tumor growth of the PTEN-/-KRAS(G12V) cells in vivo. In addition to growth promotion, activation of the ...

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UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer

UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer

... the Ras/MAPK path- way promotes cyclinD1 expression and inhibits the p21 and p27 levels ...Moreover, MAPK signaling path- way is correlated with cell adhesion, angiogenesis, inva- sion, and ...

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LIN 39 and the EGFR/RAS/MAPK pathway regulate C  elegans vulval morphogenesis via the VAB 23 zinc finger protein

LIN 39 and the EGFR/RAS/MAPK pathway regulate C elegans vulval morphogenesis via the VAB 23 zinc finger protein

... Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during metazoan development, but their role in controlling organ morphogenesis ...

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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

... that RAS/ MAPK VM mutations are strong activators of the MAPK signaling pathway and overlap with the cancer allele spectrum is in line with the hypothesis that lethal genes survive by mosaicism ...

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Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

<p>Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways</p>

... RT-qPCR was used to assess mRNA expression of compo- nents of the Ras-MAPK and NT3-TrkA pathways. The synthesis of cDNA from the HP or PFC was carried out using the PrimeScript RT reagent Kit (TAKARA), and ...

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miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

... and Ras-MAPK pathway components (GRB2, ERK2, RSK1 and ...the Ras-MAPK pathway resulted in in- creased sensitivity to cisplatin, suggesting that the miR- 634-mediated repression of this pathway ...

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Original Article Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer

Original Article Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer

... in Ras-MAPK pathway, which are dually phosphorylated on threonine and tyrosine residues by mitogen- activated protein kinase/extracellular signal- regulated kinase kinase (MEK) ...

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Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration

Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration

... the Ras/MAPK pathway, which is tightly controlled by the feedback attenuator Dual specificity phosphatase 6 (Dusp6), an ERK ...attenuates Ras/MAPK signaling during regeneration and that ...

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Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

... the RAS pathway contributes to myeloid ...the RAS-MAPK-pathway by miR-181a mimics represents a novel promising therapeutic approach for AML and possibly for other RAS-driven ...

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Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

... the Ras mutations at codon 13 in many human cancers ...of Ras, but not the wild-type Ras. Among the components of the Ras/MAPK pathway, harmine specifically targets mutated Ras ...

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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

... Sporadic vascular malformations (VMs) are congenital malforma- tions of blood vessels with high associated morbidity and limited treatment options (Figure 1 and Figure 2). VMs have traditionally been divided into ...

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Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

... the MAPK and the PI3K pathways ...of MAPK signaling, such as KRAS, BRAF and NRAS mutations, results in clinical resistance to anti-EGFR-based ...the MAPK pathway ...suppress MAPK activation in ...

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Computational Biology of Ras Proteins

Computational Biology of Ras Proteins

... other Ras proteins (Table 6) (PDB ID: 1U8Y; Nicely et ...M- Ras are both proto-oncogenes whose proteins promote cell division, while Rap1a inhibits cell division and Rheb controls cell growth instead of ...

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PHYLOGENETIC ANALYSIS OF RAS SUBFAMILY PROTEINS

PHYLOGENETIC ANALYSIS OF RAS SUBFAMILY PROTEINS

... human RAS subfamily proteins with other homologous sequences revealed highly conserved ...selected RAS proteins such as their hydrophilic nature; alpha–helical structure and close evolutionary relationship ...

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Pharmaceutical standardization of Kapha Ketu Ras

Pharmaceutical standardization of Kapha Ketu Ras

... Ashuddha shankha; 2- Pottali of Shankha; 3- Swedana in nimbuswarasa; 4- Shoditashankha; 5- Bhavana of shankha with Nimbhusarasa; 6Sealed sharavasamputa; 7-Gaja puta; 8- Shankhabhasma; 9-[r] ...

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A Non-Mendelian MAPK-Generated Hereditary Unit Controlled by a Second MAPK Pathway in Podospora anserina

A Non-Mendelian MAPK-Generated Hereditary Unit Controlled by a Second MAPK Pathway in Podospora anserina

... PaMpk1 MAPK pathway during growth, whereas this cascade normally signals stationary ...another MAPK pathway, PaMpk2, is crucial at every stage of the fungus life cycle, in particular those controlled by ...

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Inhibition of RAS in diabetic nephropathy

Inhibition of RAS in diabetic nephropathy

... of RAS in DKD plays a major role in disease pathophysiology and is implicated in its ...on RAS, hemodynamic changes, and other pleiotropic effects that include anti-inflammatory, antioxidant, antithrombotic ...

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Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies

Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies

... of Ras protein pairs that are similar in sequence but separated from each other in the interactome (Panel III in Figure 4) contrasts with the abundance of highly divergent Ras pairs close in the network ...

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