recombinant factor VIII
A new recombinant factor VIII: from genetics to clinical use
... 71. Laguna P, Vdovin V, Rageliene L, Abad-Franch L, Lindblom A. Overview of a global clinical trial programme with turoctocog alfa, a new recombinant factor VIII: the Guardian™ programme. Presented ...
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Recombinant Factor VIII versus plasma derived Factor VIII in the management of haemophilia A: an examination of the costs and consequences
... A further cost consideration for individual purchasers is the magnitude of the resource consequences for so called ‘big bleed episodes’ i.e. major bleeding episodes requiring considerable medical attention. These ...
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Potential role of a new PEGylated recombinant factor VIII for hemophilia A
... coagulation factor (F) VIII, is an X-linked bleeding disorder with an approximate incidence of one in 5,000 male ...and recombinant FVIII products, the benefits of primary prophylaxis were ...
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Matching-adjusted indirect comparisons of efficacy of BAY 81-8973 vs two recombinant factor VIII for the prophylactic treatment of severe hemophilia A
... Conclusion: This indirect comparison found that prophylaxis with BAY 81-8973, even includ- ing the lower frequency of two times a week and lower factor VIII consumption, has efficacy comparable to rAHF-PFM ...
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Prevalence of factor VIII inhibitors in haemophilia a patients who received factor VIII therapy
... the recombinant FVIII ,the majority of patients in developed countries treated with recombinant ...Several recombinant Factor VIII products are available ,the majority of them ...
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Recombinant factor VIII in the management of hemophilia A: current use and future promise
... length recombinant factor VIII there are many studies in patients with hemo- philia A, but none that directly compares one generation with another product or ...with factor VIII ...
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Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... In plasma, von Willebrand factor (vWf) associates with Factor VIII (FVIII); however, the site at which these pro- teins first interact has not been defined. Administration of 1-desamino-8- D ...
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Detection of Factor VIII Inhibitors in Hemophilia A Patients
... factor VIII will be progressively neutralized. If the amount of factor VIII added and the duration of incubation are standardized, the strength of the inhibitor may be measured in units ...
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Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII)
... The relation between functional antihemophilic factor (AHF) activity and AHF-like antigen was studied in the plasma of 25 known carriers of hemophilia. In 23 cases, this relationship was significantly different ...
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Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model
... coagulation factor, factor VIII, is frequently complicated by the development of neutralizing ...tissue factor, a known initiator of coagulation, was investigated as a factor ...
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Factor VIII/von Willebrand factor protein Galactose a cryptic determinant of von Willebrand factor activity
... asialo Factor VIII/von Willebrand factor protein with galactose oxidase resulted in a progressive loss of von Willebrand factor activity with no effect on procoagulant ...
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Acquired Factor VIII Inhibitor in Juvenile Rheumatoid Arthritis
... Acquired circulating inhibitor to factor VIII (FVIII) has been reported in both hemophiliacs and nonhe- mophiliac&.. FVIII inhibitor occurs in 10% to 20% of patients with severe, cla[r] ...
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Studies on the purification of antihemophilic factor (factor VIII): I Precipitation Of Antihemophilic Factor By Concanavalin A
... Concanavalin A precipitates antihemophilic factor from normal plasma. Combining this precipitation with other techniques, we were able to separate fractions rich in antihemophilic activity from human plasma with ...
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Use of Recombinant Factor VIIa in Obstetrics
... Postpartum acquired haemophilia A, characterized by postpartum development of an inhibitor against FVIII, constitutes 7-21% of acquired haemophilia A cases and is a rare but serious complication of pregnancy associated ...
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Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... Comparison of the multimers produced by reduction with the multimers produced by cross- linking, demonstrated the absence of odd-numbered multimers from the reduced series. Thus, the protomeric unit appears to be the ...
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Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease
... carbohydrate. Cold insoluble globulin did not represent a significant contaminant in these analyses. 11 of the von Willebrand's disease patients with normal FVIII/vWF carbohydrate had abnormal crossed ...
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High factor VIII levels contribute to the thrombotic risk in families with factor V Leiden
... In order to explam the different venous thrombotic nsks in first-degree relatives of probands of selected thrombophilic families and first-degree relatives of unselected patients with th[r] ...
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IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII
... of recombinant concen- trates (OR = ...or recombinant FVIII, and previous use of single ...or recombinant FVIII, and previous use of single or multiple concen- trates, the OR was ...
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Effects of triiodothyronine induced hypermetabolism on factor VIII and fibrinogen in man
... subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < ...in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol ...
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Some Effects of Calcium on the Activation of Human Factor VIII/Von Willebrand Factor Protein by Thrombin
... When Factor VIII/von Willebrand factor (FVIII/vWF) protein is rechromatographed on 4% agarose in 0.25 M CaCl 2 , the protein and vWF activity appear in the void volume, but most of the FVIII ...
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