recombinant human interferon-γ
Expression and Purification of Human Interferon Gamma Using a Plant Viral Vector
... the human interferon-gamma (INF-γ) in planta. The INF-γ gene was in frame inserted between the P1 and HC-Pro ORFs of the ZYMV ...of recombinant viruses from infected plant and ...
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Recombinant LPG3 Stimulates IFN-Γ and TNF-Α Secretion by Human NK Cells
... The innate immune responses against Leish- mania include natural killer (NK) cells, cyto- kines and phagocytes (11). Recognition of pathogens by antigen presenting cells (APCs) such as dendritic cells leads to production ...
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Optimisation of CHO cell growth and recombinant interferon-γ production
... of recombinant proteins in CHO cells are ...producing human recombinant IFN-y, has been previously adapted to a serum-free medium (Hayter et al, ...(BSA), human transferrin, bovine insulin, ...
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The Influence of Glycans-Specific Bioconjugation on the FcγRI Binding and In vivo Performance of 89Zr-DFO-Pertuzumab
... than human) FcγRI, and — as we have seen — the affinity of the pertuzumab-based immunoconjugates for muFcγRI is rather ...with human hematopoietic stem cells in order to facilitate the expression of a ...
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Streptococcal antigen in the pathogenesis of Behçet's disease
... and response to treatment) – must continue and may proceed more quickly if coordinated on a multicentre, multinational basis. Therapeutic trials continue but to date there are surprisingly few controlled studies (e.g. ...
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Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy
... Results: Tofacitinib, dosed orally or intracecally, inhibited, with similar efficacy, oxazolone-induced colitis, represented by improvements in the disease activity index and its sub-scores (body weight, stool ...
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The human microglial HMC3 cell line: where do we stand? A systematic literature review
... different human chemo- kines, including MCP-1, MIP-1β, RANTES, and frac- talkine (albeit to a lower extent) or in response to IL-1β (1–50 ...from human peripheral blood monocytes infected with Mycobacter- ...
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Effector mechanisms of interleukin 17 in collagen induced arthritis in the absence of interferon γ and counteraction by interferon γ
... As levels of IL-17 were found to be significantly lower in wild- type mice as compared with IFN-γR KO mice and because IFN-γ profoundly inhibits the effector function of IL-17, we expected the protective effect of ...
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Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells
... IFN γ alters the gene expression profile of hfcMSCs To determine transcriptional responses to inflammatory stimuli, hfcMSCs were cultured in the presence or ab- sence of IFNγ for 7 days, prior to RNA ...and ...
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Immunological profiles in HIV positive patients with or without opportunistic infections and the influence of highly active antiretroviral therapy: a systematic review and update
... Oropharyngeal candidiasis (OPC), caused primarily by Candida albicans, remains the most common fungal lesion among HIV positive individuals despite the invention of HAART [94,95]. A study by Lilly et al. [40] evaluated ...
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Balance of IL 10 and Interferon γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis
... IFN- γ and of IL-12 p40 were observed during active disease, significantly decreasing after treatment whereas in vitro Leishmania antigen-stimulated IFN- γ production by PBMC exhibited an inverse pattern ...
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Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments
... of interferon-γ (IFN-γ) and interleukin-5 (IL-5) in nasal lavage fluid from children with allergic rhinitis after different types of pharmacologic treatment (mometasone, montelukast, or ...
6
The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... Figure 1 Effects of mithramycin on gliostatin/thymidine phosphorylase (GLS/TP) promoter activity based on deletion constructs. Closed ovals indicate Sp1-binding sites. Open ovals indicate interferon-stimulated ...
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Extent of liver inflammation in predicting response to interferon α & Ribavirin in chronic hepatitis C patients: a cohort study
... to Interferon α-2b and Ribavirin for duration of 48 weeks in patients ≤ 40 years was 48% compared to 34% in those more than 40 years of age ...of Interferon α and Ribavirin in other studies as well ...
10
Recombinant [gamma prime] fibrinogen and its interaction with factor XIII
... calculated from ELISA binding curves. While this decrease may be due to differences in binding to fibrinogen in solution versus fibrinogen immobilized on a plate, it may also have its origins in the construction of the ...
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Original Article Efficacy analysis of the aminolevulinic acid photodynamic therapy combined with recombinant human interferon α-2b ointment in the treatment of precancerous skin lesions and superficial basal cell carcinoma in elderly patients
... 5-ALA is an important photosensitizer in the human body. It can be synthesized from gly- cine, caprylic acid, and coenzyme A in the processes of hemoglobin synthesis [14]. Only a small amount of ALA is contained ...
7
Gamma Interferon Treatment of Patients with Chronic Granulomatous Disease Is Associated with Augmented Production of Nitric Oxide by Polymorphonuclear Neutrophils
... A multicenter study showed that recombinant human gamma interferon (IFN-g) administered subcutaneously (s.c.) three times a week significantly reduced serious infections (17). This regimen has ...
5
Disseminated Mycobacterium avium complex infection mimicking malignancy in a patient with anti IFN γ autoantibodies: a case report
... A bulging mass was found in his anterior chest wall (Fig. 1). Notable laboratory findings included a white blood cell count of 11,400/μL and a C-reactive protein level of 8 mg/L. Chest computed tomography revealed an ...
5
The effect of process variables on the glycosylation of gamma-interferon produced in CHO (Chinese hamster ovary) cells
... f human therapeutics become more stringent the ability to monitor product authenticity is given greater ...a human protein o f therapeutic use, was chosen as a suitable model ...produced recombinant ...
277
Evaluation of expression systems of recombinant human interferon gamma
... Gamma interferon-activated sequence; IRF-1, Interferon- regulated factor-1; Jak, Janus kinase; NF-κB, Nuclear factor kappa-light- chain-enhancer of activated B cells; PARP, Poly (ADP-ribose) polymerase; ...
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