recombinant human interleukin-3
Validation of biological activity testing procedure of recombinant human interleukin-7
... The suggested method for biological activity testing of rhIL7 in human PBMCs was validated for confirmation of its biological activity quantita tive characteristic. Validation has confirmed that this method ...
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Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 cause basophil histamine release
... of human cells, including T lymphocytes and alveolar ...on human basophils and/or mast cells and therefore tested preparations of human recombinant IL 3, IL 4, IL 5, granulocyte ...
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Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities
... of human recombinant IL-3 and granulocyte- macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target ...that human ...
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Original Article Effect of human recombinant interleukin-10 on cytokines in adjuvant arthritis rat
... Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease that mainly causes sys- temic small arthropathy [1]. Its clinical feature is progressive and symmetric joint destruction, then causing joint swelling, ...
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Development of the method for microbiological purity testing of recombinant human interleukin-7-based product
... During the study of antimicrobial effect neu- tralization potential, the product test samples were prepared using a sterile solution, and monoculture suspension of one of the following test microorga- nisms: B. subtilis ...
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Cloning and Expression of Recombinant Human Interleukin-7 in Chinese Hamster Ovary (CHO) Cells
... The full-length coding sequence of human IL-7 (NM_000880.3) was commercially synthesized in pUC57 by ShineGene (Shanghai, China). After digestion with SalI and XbaI restriction endonucleases (Thermo Fisher ...
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas Soriano RA *1 and Gonzalez M 2
... the interleukin-11 pathway as outlined in Figures 1 and 2 ...of recombinant human interleukin 11 (rhIL-11) in severe chemotherapy-induced thrombocytopenia who those receiving a variety of ...
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Stimulation of human hematopoietic colony formation by recombinant gibbon multi colony stimulating factor or interleukin 3
... murine interleukin 3 was isolated from a gibbon T cell line and expressed in monkey COS ...or interleukin 3, is stimulatory to human target ...enriched human bone marrow and ...
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Effect of recombinant human interleukin-7 on Pseudomonas aeruginosa wound infection
... combinant human interleukin-7 was provided by UA Pro-Pharma LLC (Kyiv, ...using recombinant DNA technology in an expression system based on the ...using ...
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Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... (CSF) recombinant interleukin 3 (IL-3), natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 mouse bone marrow and spleen ...
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OPTIMIZATION OF THE CULTURE MEDIUM COMPOSITION TO INCREASE THE BIOSYNTHESIS OF RECOMBINANT HUMAN INTERLEUKIN-7 IN ESCHERICHIA COLI
... It should be noted that for two investigated plant extracts, stimulating effect on culture growth and the content of recombinant protein was found in the range of concentrations of 0.1-1%. In this case, when using ...
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A common polymorphic allele of the LH beta-subunit gene is associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology
... on human follicles already from the start of the cycle [8], the synergizing effect of LH and FSH ap- pears to be most prominent from the mid-follicular phase and ...
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Biological properties of recombinant human monocyte derived interleukin 1 receptor antagonist
... recombinant IL-1ra also blocks IL-1 alpha and IL-1 beta stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes, and of collagenase production by the synovial cells. A 50% ...
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Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin 3
... Following our preliminary findings of inhibited ability of splenocytes to produce IL-3 in mice with experimental APLS 16, and given the efficacy of IL-3 in preventing fetal loss in a str[r] ...
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... and -13 and that increased expression of IL-1Ra can reduce the activity of MMP-1, -3, -7 and -13 in tissue explants [6], we investigated the effect of TNF-α stimulation on expression of MMPs from each of these ...
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Recombinant interferon alpha selectively inhibits the production of interleukin 5 by human CD4+ T cells
... So far, the effects of IFN-a on the profile of cytokines secreted by human T cells has been mainly studied in systems where IFN-a was added in bulk cultures of PBMC before in vitro re- stimulation. In these ...
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TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling
... HLF: Human lung fibroblasts; IL-6: Interleukin-6; IL-6R: Interleukin-6 receptor; ILD: Interstitial lung disease; IPF: Idiopathic pulmonary fibrosis; N-HLFs: Normal human lung fibroblasts; p: ...
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Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1 Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163 171
... natural human interleukin (IL-1)1 beta and human recombinant (hrIL)-1 alpha and beta are potent stimulators of HA production by fibroblasts in ...
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Fibroblast chemotaxis induction by human recombinant interleukin 4 Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70 88 and 89 122
... Fibroblast Chemotaxis Induction by Human Recombinant Interleukin-4 Identification by Synthetic Peptide Analysis of Two Chemotactic Domains Residing in Amino Acid Sequences 70-88 and 89-1[r] ...
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Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease
... of interleukin-5 in serum and BAL fluid, and increased severity of the asthmatic response ...for interleukin-5, the magnitude of baseline airflow obstruction (FEV 1 ), and bronchoconstrictor reactivity to ...
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