Recombinant Interferon Gamma
Recombinant interferon gamma primes alveolar macrophages cultured in vitro for the release of leukotriene B4 in response to IgG stimulation
... of interferon-gamma and challenged with HAIgG. Interferon- gamma did not alter the response to ...of interferon-gamma was both time and dose dependent; it also was specific since ...
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Recombinant interferon gamma augments phagocyte superoxide production and X chronic granulomatous disease gene expression in X linked variant chronic granulomatous disease
... of interferon gamma (IFN-gamma) to ameliorate the physiologic defect of chronic granulomatous disease (CGD) by studying its effects on CGD phagocyte superoxide generation, NADPH oxidase kinetics, ...
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Organ specific cytokine therapy Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon gamma to the human lung
... In the context of the central role of the alveolar macrophage in host defense of the respiratory epithelial surface, and the ability of IFN-gamma to activate mononuclear phagocytes, we have evaluated strategies to ...
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Gamma Interferon Treatment of Patients with Chronic Granulomatous Disease Is Associated with Augmented Production of Nitric Oxide by Polymorphonuclear Neutrophils
... 1987. Recombinant interferon gamma augments phagocyte superoxide production and chronic granulomatous disease gene expression in X-linked variant chronic granu- lomatous ...
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Evaluation of expression systems of recombinant human interferon gamma
... the recombinant Pichia pastoris. For this purpose; the human interferon gamma (hIFNγ) gene, which has a therapeutic value against a wide variety of diseases like cancer, hepatitis, and tuberculosis ...
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Synergistic inhibition of human cytomegalovirus replication by interferon alpha/beta and interferon gamma
... BioMed CentralVirology Journal ss Open AcceResearch Synergistic inhibition of human cytomegalovirus replication by interferon alpha/beta and interferon gamma Bruno Sainz Jr?, Heather L LaMarca?, Rober[.] ...
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Inducible Expression of Human Gamma Interferon
... Construction of recombinant plasmid (pMPGB 43P2(6)K-IFN-γ. The resulting PCR product, the 558 base-pair (bp) of HuIFN-γ coding sequence containing restriction sites of BamHI enzyme and expressing vector ...
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Inhibition by interferon gamma of human mononuclear cell mediated low density lipoprotein oxidation Participation of tryptophan metabolism along the kynurenine pathway
... IFN gamma failed to induce degradation of arginine, and nitrite was not detected in the cell supernatant, indicating that nitric oxide synthase was not induced under these ...IFN gamma, ...
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The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... Figure 1 Effects of mithramycin on gliostatin/thymidine phosphorylase (GLS/TP) promoter activity based on deletion constructs. Closed ovals indicate Sp1-binding sites. Open ovals indicate interferon-stimulated ...
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Aqueous humour protein imbalances in primary open angle glaucoma and their effects on trabecular meshwork cell function
... Interferon alpha Interferon gamma Intraocular pressure Induced pluripotent stem cells Juxtacanalicular tissue Kilodalton Leukemia inhibitory factor Limb development membrane protein 1 li[r] ...
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DNA methylation of the interferon-gamma promoter in association with overexpression of the interferon-gamma gene in periodontal disease
... inflammatory response to these periodontopathogens (Offenbacher 1996). The bacterial insult at the biofilm-gingival interface results in the direct destruction of host tissues through bacterial virulence factors such as ...
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Physiological evidence for diversification of IFNα and IFNβ mediated response programs in different autoimmune diseases
... 23 interferon response genes (IRGs) (see Additional file 1: Table S1) were selected that are reflective of a communal type I IFN signature between autoimmune ...
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The Antiviral Response to Gamma Interferon
... A role for alpha/beta interferon (IFN- ␣ /  ) in the IFN- ␥ antiviral response has long been suggested. Accordingly, possible roles for autocrine or double-stranded-RNA (dsRNA)-induced IFN- ␣ /  in the IFN- ␥ ...
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High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency
... 6. Holland SM, Dorman SE, Kwon A, et al. Abnormal regulation of inter- feron gamma, interleukin-12, and tumor necrosis factor alpha in inter- feron gamma receptor-1 deficiency. J Infect Dis. ...
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Extent of liver inflammation in predicting response to interferon α & Ribavirin in chronic hepatitis C patients: a cohort study
... HCV genotypes 2 and 3, low viral load (< 2 million IU/ml), absence of cirrhosis, mild or absent portal fibro- sis on pretreatment liver biopsy are favorable predictors for response to standard Interferon α and ...
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Zhang, Wenli (2012): Adenovirus-based gene therapy approaches for hemophilia B. Dissertation, LMU München: Medizinische Fakultät
... Another vector that holds great promise for hemophilia gene therapy is represented by recombinant adeno-associated viral vector (rAAV). AAVs have a favorable safety profile because of their non-pathogenic nature, ...
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Antiviral Activity of Salmonid Gamma Interferon against Infectious Pancreatic Necrosis Virus and Salmonid Alphavirus and Its Dependency on Type I Interferon
... IFN- ␥ has been identified from several fish species, includ- ing rainbow trout and Atlantic salmon (19, 28, 38, 53, 61, 62). In contrast to the type I IFNs, fish and mammalian IFN- ␥ are similar in exon/intron structure ...
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Risk of latent TB infection in individuals employed in the healthcare sector in Germany: a multicentre prevalence study
... guidelines of occupational safety and health legislation (OSH) HCWs are screened routinely depending on risk assessment. All HCWs working in pulmonary wards and labs (contact with contagious TB-material or TB cases) are ...
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Lymphocyte responses in the lung in patients with respiratory disease
... Bronchoalveolar Lavage Leukocyte Populations by Flow Cytometry in Patients Investigated for Respiratory Disease. An essential role for interferon gamma in[r] ...
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Recognition of herpesviruses by the innate immune system
... Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection.. Alpha/Beta interferon and gamma interferon synergiz[r] ...
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