Reduced folate carrier
PREVALENCE OF GLUTAMATE CARBOXYPEPTIDASE II C1561T, REDUCED FOLATE CARRIER 1 A80G, AND METHIONINE SYNTHASE A2756G GENE POLYMORPHISMS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AMONG SOUTH INDIANS
... in folate transport and uptake, the folate pathway, and homocysteine (Hcy) metabolism and various polymorphisms have been identified in these enzymes methylenetetrahydrofolate reductase (MTHFR), methionine ...
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The reduced folate carrier (SLC19A1) c 80G>A polymorphism is associated with red cell folate concentrations among women
... The SLC19A1 c.80G>A polymorphism was not strongly associated with either serum folate or homocysteine concentrations in either men or women. However, in women, but not in men, this polymorphism explained 5% of ...
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Lower Erythrocyte GST Activity in Autism Spectrum Disorder (ASD) Patients Compared to Normal Controls
... the reduced ability to remove metals including mercury or other neurotoxins from the system, and environmental exposure ...of Reduced Folate Carrier I (RFC1) gene, Methylenetetrahydrofolate ...
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MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma
... identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma ...
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Original Article Gene polymorphisms in the folate metabolic pathway and risk of pediatric acute lymphoblastic leukemia: a case-control study in a Chinese population
... Reduced folate carrier 1 (RFC1) facilitates the transport of 5-methyltetrahydrofolate from the circulation to peripheral ...in folate-related genes may disturb the metabo- lism of ...
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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics
... cellular folate cofactors ...the reduced folate carrier (RFC, or solute carrier, family 19, member 1 [SLC19A1]), and, to a much lower extent, via folate receptors or low-pH ...
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Folates for reduction of risk of neural tube defects: using oral contraceptives as a source of folate
... The folate most commonly found in the bloodstream is 5-methyltetrahydrofolate monoglutamate ...of folate carrier in the embryonic neural tube, supporting the critical role for folate during ...
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Reduced expression of folate transporters in kidney of a rat model of folate oversupplementation
... has reduced the incidence of neural tube birth defects by as much as 50 %, but at the same time, there has been another, totally unexpected ...chronic folate oversupplementation on the folate ...
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Key words
... the reduced form of folic acid ...the folate concentrations in serum were higher in the 80AA genotype than the allele G variant: 19 mmol/L vs 15 mmol/L, ...the reduced folate carrier in ...
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Expression of Folate Pathway Genes in Stage III Colorectal Cancer Correlates with Recurrence Status Following Adjuvant Bolus 5-FU-Based Chemotherapy
... identify folate pathway genes with possible impact on leucovorin metabolism, a retrospective study was performed on 193 patients with stage III colorectal ...(proton-coupled folate transporter) and ...
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Cancer chemotherapy: targeting folic acid synthesis
... (reduced folate carrier, RFC). After folate was discovered to be vital to many cellular processes, the antifolates aminopterin and methotrexate (MTX) were synthesized in the early ...
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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
... on folate utilizing enzymes in C1 metabolism” in which he described the enzymology and structural biology of target enzymes including GARFTase, AICARFTase/in- osine monophosphate cyclohydrolase (ATIC), SHMT1, ...
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The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
... yeast folate, which were removed from their normal food matrix and ...these folate ex- tracts, which has been described in detail elsewhere (26), was developed by us specifically for use in folate ...
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1.4899051.pdf
... The development of photovoltaic (PV) technology has drawn considerable attention in the past decades because of its potential in harnessing solar energy to solve today’s energy crisis. Historically, breakthrough of the ...
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Long duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions
... 5JTHF and 5mTHF Concentrations, and the Ratio of MTX to Reduced Folate, in the Effusion Fluid and Serum of Two Patients Receiving 120-h Intrapleural Infusions Steady-state 5mTHF concentr[r] ...
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Fermentation of Milk Using Folate-Producing Lactic Acid Bacteria to Increase Natural Folate Content: A Review
... extracellular folate synthesized by LAB depends on the degree of polyglutamylation or the pH of growth ...extracellular folate distribution only depends on the degree of polyglutamylation and is not ...
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THD Analysis of Carrier Overlapping PWM Strategies for DCMI With Reduced Number Of Switches
... frequency carrier triangle, the two signals are mixed in a comparator whose output is high when the sine wave is greater than the triangle and the comparator output is low when the sine wave or typically called ...
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Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report
... Hyperhomocysteinemia (HHCY) has been underlined as an emerging risk factor for several diseases such as arterial and/or venous thrombosis [1], adverse pregnancy out- come [2,3], congenital malformations [4] and vascular ...
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Folate-Conjugated Gold Nanoparticles (Synthesis, Characterization and Design for Cancer Cells Nanotechnology-based Targeting)
... or folate (folic acid salt) is an important vitamin required for the healthy functioning of all ...cells. Folate is necessary for DNA nucleotide synthesis and cell ...more folate than a healthy cell ...
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PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case–control study in a population with relatively low folate intake
... Zhu et al. reported that PCMT1 gene polymorphisms (rs4816 and rs4552) in infants were a genetic modifier for the risk of spina bifida in a Californian population (Zhu et al. 2006). However, our recent research showed ...
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