Renal Mesangial Cells
Original Article Abnormal expression of proteins in human renal mesangial cells stimulated by high levels of uric acid
... human renal mesangial cells (HRMC) as a model and found that cell proliferation of HRMC was significantly suppressed with increasing concentrations of UA in culture ...HRMC cells treated by ...
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Nitric oxide stimulates the stress activated protein kinase p38 in rat renal mesangial cells
... Rat renal mesangial cells were cultured as described previously (Pfeilschifter, ...Single cells were then cloned by limited dilution on 96-microwell ...apparent mesangial cell ...
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Original Article Proinflammatory-factors-carrying-microvesicles from monocytes induced by high glucose enhance the activation of HIF/VEGF pathway in human renal mesangial cells
... Objectives: Renal mesangial expansion has been identified as a major factor contributing to glomerulo- sclerosis, a typical symptom of diabetic ...between cells and organs, are involved in a ...
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Proteomic Identification of 14-3-3ζ as an Adapter for IGF-1 and Akt/GSK-3β Signaling and Survival of Renal Mesangial Cells
... in mesangial cells ...in mesangial cells ...of cells types [29]; however, IGF-1’s effects on CREB activity in mesangial cells are not known ...in mesangial ...
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Original Article MicroRNA-124 represents a novel diagnostic marker in human lupus nephritis and plays an inhibitory effect on the growth and inflammation of renal mesangial cells by targeting TRAF6
... SLE is an autoimmune disease affecting multi- ple organs and having a recurrent progression. As a major and severe complication of SLE, LN easily develops into end-stage renal disease, which is associated with ...
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Connective tissue growth factor antagonizes transforming growth factor ?1/Smad signalling in renal mesangial cells
... HeLa cells were transiently co-transfected with Renilla and the 3TP-lux promoter reporter ...The cells were treated with CTGF, TGF- β 1 or both CTGF and TGF- β 1 together 24 h later for a further 24 ...HK2 ...
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Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells
... and renal or non-renal cells with Smad3 knock- down suggested Smad3 may be a critical medi- ator in TGF-β-induced profibrotic responses [4, 19, 20, ...of renal mesangial matrix degrada- ...
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In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells
... MES-13 cells synthesize IGF-1 (Additional file 1) and since sensitivity to IGF-1 is increase in the InsR silenced MCs, in our in vitro model these endogenously produced IGF-1 possibly ...
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Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
... sensitize cells to apoptotic signals and was originally identified as a gene induced in apoptotic prostate cancer cells ...given mesangial cell function in the synthesis of extracellular matrix, PAWR ...
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induced fibronectin production in rat mesangial cells
... al cells (PECs) and endothelial cells [22]. Renal mesangial cells have similar characteristics as vascular smooth muscle cells, which are rich in caveolae as ...in ...
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Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide Role in the vascular and renal complications of diabetes mellitus
... chemically inactivate nitric oxide (NO), a potent endothelial cell-derived vasodilator and antiproliferative factor. Since mesenchymal cell proliferation is an early and characteristic lesion of diabetic vasculopathy and ...
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Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
... determination. Mesangial expansion was evaluated by Periodic Acid Schiff staining, renal fibrosis was determined through Masson ’ s trichrome staining and neuronal nitric oxide synthase (nNOS) expression in ...
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An in vitro model of renal inflammation after ischemic oxidative stress injury: nephroprotective effects of a hyaluronan ester with butyric acid on mesangial cells
... released cells were then cultured in RPMI 1640 medium (Lonza, Basel, Swit- zerland) supplemented with 10% fetal bovine serum, 100 U/ mL penicillin, 100 μg/mL streptomycin (all purchased from EuroClone, Pero, ...
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Hemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report
... Our case report benefits from tremendous advances that have implicated mutations in complement genes and podocytopathy in the pathogenesis of HUS, which provide a new lens through which to view the biology of the associ- ...
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Development of membranoproliferative glomerulonephritis-like glomerulopathy in a patient with neutrophilia resulting from endogenous granulocyte-colony stimulating factor overproduction: a case report
... of renal dys- function and proteinuria after the identification of neu- trophilia with G-CSF overproduction, suggested a relationship between the patient’s neutrophilia with G-CSF overproduction and the ...
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Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study
... predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick ...
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Membranoproliferative glomerulonephritis complicating Waldenström’s macroglobulinemia
... myeloma, renal involvement in Waldenström’s macroglobulinemia (WM) is much more seldom and often manifests as IgM deposits along the glomerular basement membranes, amyloidosis or lym- phomatous infiltration of the ...
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Collapsing Focal Segmental Glomerulosclerosis in a Patient with Systemic Lupus Erythematosus
... There is currently no evidence based therapy for CG and therapeutic options available are derived from empiric approach of treating it as other renal disorders or associated diseases. Recommendations for current ...
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Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases
... Idiopathic MN is recognized as an autoimmune dis- ease [17]. Recently, progress has been made in under- standing the pathogens of idiopathic MN with the finding of M-type PLA2R as the target antigen of podo- cytes in ...
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Hana S. Alahmari el al JMSCR Volume 07 Issue 09 September 2019 Page 247
... 1-2 cells/microliter, WBC 2-3 cells/microliter, standard renal profile and normal C3-C4 ...mild mesangial proliferation and focal tubulointerstitial chronic ...
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