renal proximal tubular cells
Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells
... human renal proximal tubular cells (HK-2) by Cell Counting Kit-8 assay and lactate dehydrogenase release assay, but we just found the toxic effect in the 5 nm GNP-treated cells at 50 nM ...
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Cytokine and Inflammatory-Related Gene Expression of Melamine Cyanurate on Human Renal Proximal Tubular Cells
... the renal tubules demands investigation of the interaction of both the soluble form and the crystallized form to (i) address how they are absorbed and localized, (ii) also at what concentrations and (iii) ...
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Original Article Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia
... by tubular atrophy with basement membrane thickening and ac- cumulation of interstitial extracellular ...human renal proximal tubular cells are sensitive to oxygen deprivation, it is ...
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Numb Protects Renal Proximal Tubular Cells from Puromycin Aminonucleoside-Induced Apoptosis through Inhibiting Notch Signaling Pathway
... of renal proximal tubular ...NRK52E cells to puromycin aminonucleoside (PA) resulted in caspase 3-dependent ...NRK52E cells to PA-induced apoptosis, whereas overexpressing Numb ...
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Nitric Oxide Activates TGF-β/SMAD Signaling Cascade in Human Renal Proximal Tubular Cells
... rat renal mesangial cells, NO has been shown to modulate the expression of a variety of ECM-related proteins, including TIMP-1 [19, ...rat renal mesangial cells ...human renal ...
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Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells
... for the observed lack of efficacy of 17864-ULS-lysozyme. First, the inhibitor levels reached within the target cells may have been too low. Treatment with a higher dose or repeated doses of 17864-ULS-lysozyme may ...
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Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways
... HK-2 cells was first studied by MTT ...HK-2 cells enhanced cell viability in a dose- dependent manner and 10 μM was the most effective ...of renal IRI are in progress in our ...
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Alpha 2 adrenergic agonists stimulate Na+ H+ antiport activity in the rabbit renal proximal tubule
... augmenting proximal tubular salt and water flux, was studied in a preparation of freshly isolated rabbit renal proximal tubular cells in ...
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Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis
... After renal injury, they are highly up- regulated in damaged renal proximal tubular cells, and can be detected in ...of renal injury is correlated with the increased urine ...
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Physiological and pathophysiological roles of the electrogenic Na+ HCO3– cotransporter NBCe1
... duct cells, IRBIT seems to coordinate epithe- lial fluid and bicarbonate secretion by stimulating both NBCe1B and cystic fibrosis conductance regulator CFTR through distinct molecular mechanisms ...duct ...
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Insulin stimulates SGLT2-mediated tubular glucose absorption via oxidative stress generation
... of renal proximal tubules ...cultured renal proximal tubular cells via SGLT2 stimulates oxidative stress generation and re- sultantly potentiates the pro-apoptotic effects of ...
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Acquired Fanconi syndrome in patients with Legionella pneumonia
... the renal proximal tubular cells (from basolateral or apical) and (ii) why the reabsorption defects developed only in the proximal tubules, not in the distal ...
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Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells
... infected cells was ...infected cells declined substantially when cells were incubated with BKV and increasing doses of MBCD ...T-Ag-positive cells when HRPTEC were incubated with either MBCD ...
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Everolimus induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase
... human renal epithelial proximal tubular cells ...of cells motility in WT HK2 cells treated with high concentrations of EVE (higher than 100 ...EVE-treated cells (p < ...
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MicroRNA-34a Is Induced via p53 during Cisplatin Nephrotoxicity and Contributes to Cell Survival
... in renal diseases, including acute kidney injury ...mouse proximal tubular cells and also in vivo during cisplatin nephrotoxicity in C57BL/6 ...cultured cells, miR-34a was induced ...
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Expression of parathyroid hormone related protein in the rat glomerulus and tubule during recovery from renal ischemia
... from renal injury is associated with release of local growth factors, we examined the expression and localization of PTHrP in normal and ischemic adult rat ...bilateral renal artery occlusion for 45 min, ...
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Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis
... HLE cells were lysed, and the membrane fraction was obtained by differential and discontinuous sucrose-gradient proce- dures as described ...ECV304 cells with either human kNBC-1 cDNA or human pNBC-1 cDNA, ...
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ENAMEL HYPOPLASIA ASSOCIATED TO PROXIMAL RENAL TUBULAR ACIDOSIS: A CASE REPORT
... Enamel is the highest mineralized tissue that covers the crown of teeth. It is formed by ameloblasts, epithelial cells derived from the embryonic oral ectoderm, through a conspicuous developmental process referred ...
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Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury
... Human renal tubular cells were pretreated with a-HSA or AGE-a-HSA for 24 hours and incubated in vehicle or a cisplatin containing medium for 24 ...
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Predominant role for C5b 9 in renal ischemia/reperfusion injury
... to renal I/R injury was probably due to the inability to generate C5b, rather than ...human proximal tubular epithelial cells have deficient expression of the C regula- tory proteins CD55 and ...
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