Replicative Senescence
p53 isoforms regulate aging and tumor associated replicative senescence in T lymphocytes
... Cellular senescence is sustained cell proliferation arrest induced either by telomere attrition (replicative senescence; ...premature senescence; ...cellular senescence of normal tissue ...
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Regulation of human naive and memory T cell populations by apoptosis and replicative senescence
... In this chapter, the new technique for measuring telomere length by flow cytometry described in the previous chapter, was used to investigate replicative senescence in antigen specific CD8^ T lymphocytes ...
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Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence
... upon replicative senescence. Our data suggest that replicative senescence might dramatically impede human mesenchymal stem cell (MSC) function via global transcriptional deregulation in ...
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The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence
... the senescence phenotype has hindered the understanding of its ...identical senescence onset, meiosis is able to segregate a determinant of senescence onset among the telomerase- negative ...
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Differential gene expression in rodent embryo fibroblasts upon replicative senescence
... that replicative senescence is under genetic control, but also that it is a dominant ...underwent senescence (Pereira-Smith and Smith, ...prevented senescence in the resulting hybrids ...
338
Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites
... upon senescence have been implicated in replicative senescence before: EGR1, also known as zinc finger protein 225, has been shown to play a central role in aging [51,52] and replicative ...
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Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells
... undergo senescence, which is characterized by a lowered differentiation potential and a reduced proliferation rate by G1 cell cycle ar- rest via p21 in a p53 independent pathway with the same result as previous ...
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Functional analysis of p16INK4a and p21CIP1 in replicative senescence
... a senescence-like arrest (MO) after only a few PDs, apparently due to the rapid accumulation of p i6^^"^“ (Brenner et a l, 1998; Foster et a l, 1998; Huschtscha et a l, 1998; Jarrard et a l, 1999; Yeager et a ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... The ends of eukaryotic chromosomes are non-coding repetitive DNA sequences (TTAGGG), which resemble DNA breaks and therefore need to be shielded [209]. Cells have attained this adjustment by masking the ends with a ...
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Replicative lifespan in rodent cells
... induce replicative senescence (Karlseder et ...a senescence response that is phenotypically indistinguishable from replicative senescence (Karlseder et ...of replicative ...
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Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence
... during replicative as well as irradiation-induced senescence (Additional file 3: Figure S3, Additional file 4: Figure S4, Additional file 5: Figure S5, Additional file 6: Figure S6, Additional file 7: ...
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The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence
... premature senescence of infected cells ...during replicative senescence of human fibro- blasts (Table 1 depicted in bold), indicating that CMV causes an immunological phenotype in early passage ...
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AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders
... Both proteins were also identified as critical mediators of replicative senescence. It had been shown that reduc- tion of AUF1 level occurred with replicative senescence and contributed [r] ...
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Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues
... fibers in the motor cortex are decreased [6], and the ability to transmit information declines accordingly. The aging process is also associated with basic cellular mechanisms such as DNA repair and mitochondrial ...
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Lodygin, Dmitri (2005): Epigenetic and pharmacological regulation of gene exprssion involved in senescence and tumor progression. Dissertation, LMU München: Fakultät für Biologie
... cellular senescence as a natural barrier for tumor development and potential target for pharmacological ...undergoing replicative senescence was used to gain insight into underlying molecular ...
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NOX4 downregulation leads to senescence of human vascular smooth muscle cells
... Along with the controversies of the casual link between ROS production and aging, there is still an open question concerning the role of ROS in cell senescence. It was suggested that ROS produced by mitochondria ...
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The role of PML ubiquitination in human malignancies
... Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and intervention ...
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Is senescence-associated β-galactosidase a marker of neuronal senescence?
... to senescence because silencing of the Glb1 gene, which encodes lysosomal β-galactosidase, does not alleviate the symptoms of senescence ...than senescence we witnessed a continued growth of neurons, ...
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SENESCENCE REGULATION IN LEAF DISCS OF RAPHANUS SATIVUS L. BY PLANT GROWTH REGULATORS IN DARK
... Protein degradation has been considered to be one of the important events during leaf senescence (Osborne 1962, Fletcher 1969, Shibaoka and Thimann 1970, Martin and Thimann 1972 b, Tetley and Thimann 1974). ...
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PubMedCentral-PMC5452723.pdf
... a senescence-associated secretory phenotype (SASP) that coincided with the development of tubulointerstitial ...with senescence, SASPs, and activation of Stat3 as well as impeded the development of ...
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