• No results found

Retinal Rod Photoreceptor Cells

Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells

Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells

... Phosphatidylinositol 3-Kinases (PI3Ks) are a family of lipid kinases that catalyze the phosphorylation of D3- hydroxyls in the inositol head group and generate several phosphorylated phosphoinositides [1]. The D3- ...

11

Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

... (Müller cells and astrocytes) has been reported to contribute to PR death in rd10 mice ...Müller cells of the retina [32, ...these retinal glial cells, respectively ...Müller cells were ...

15

Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203

Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203

... cell-based photoreceptor differentiation strategies have been the recent focus of therapies for retinal degenerative ...(ES) cells and neural retina differentiation cocktails, including DKK1 and ...

11

Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons

Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons

... disrupts retinal pigment epithelium (RPE) cells and destroys rod and cone photoreceptor cells in the central part of the retina, known as the ...a rod-dominant retina without a ...

10

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

... to retinal dystrophy all patients from this pedigree reported high to very high myopia to diopters Table None of the patients reported fertility problems and indeed patient P had five children ...

46

Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina

Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina

... all retinal layers was observed, and ROS were stable in numbers but were 19% shorter than ...normal rod function, however two parameters of the photoresponse significantly differed from WT ...isolated ...

15

Proteins affecting rod photoreceptor differentiation in the murine retina: a proteomics approach with emphasis on mTOR

Proteins affecting rod photoreceptor differentiation in the murine retina: a proteomics approach with emphasis on mTOR

... of rod differentiation, no detectable rod function and all the photoreceptors have cone like characteristics (Mears et ...induces rod promoter activity alone and in combination with cone rod ...

104

Characterization of the retinal proteome during rod photoreceptor genesis

Characterization of the retinal proteome during rod photoreceptor genesis

... post-mitotic rod precursors were able to successfully and functionally integrate into the mature ...stem cells to adopt a photoreceptor ...the retinal environment during normal ...

8

Gene expression changes during retinal development and rod specification

Gene expression changes during retinal development and rod specification

... cell–derived photoreceptor precursors into retinas with advanced disease may provide a complementary ...of cells that can be routinely differ- entiated into the required cell types are ...mouse ...

27

Viral mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

Viral mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

... early retinal expression, which was visible in retinal flat mounts at P8 (Supplemental Figure 1A; supplemental material available online with this article; ...1A). Retinal flat mounts revealed that ...

13

Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa

Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa

... study retinal morphology prior to photo- receptor loss, using immunohistochemistry and confocal microscopy on cryosections, since little is known about how the mutation affects the retina during this ...in ...

14

COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids

COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids

... of photoreceptor precursor cells, the re- porter gene tdTomato was integrated into the marker gene CRX , which is expressed in photoreceptor precur- sor cells, resulting in an engineered ESC ...

12

Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa

Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa

... the retinal pigment epithelium and not photoreceptors ...lymphoblastoid cells from RP patients, Rio Frio et ...lymphoblastoid cells may not represent the situation in photoreceptor ...

18

Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development

Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development

... Bipolar cells are interneurons that relay information from photoreceptors to RGCs and are divided into ten subtypes in mouse (Wassle et ...into rod bipolars, all of which are of the ON type, and cone ...

11

Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate

Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate

... During retinal development, the Notch signaling pathway regulates both cell cycle exit and cell fate specification (Jadhav et ...of retinal development resulted in precocious cell cycle exit and the ...

10

Factors influencing rod photoreceptor differentiation in the mouse retina: a focus on insulin like growth factor 1

Factors influencing rod photoreceptor differentiation in the mouse retina: a focus on insulin like growth factor 1

... 1979). Rod photoreceptors are extremely sensitive and function in low light vision while cones are differentially sensitive to specific wavelengths of ...bipolar cells in the outer plexiform layer ...

170

Noninvasive Imaging of the Human Rod Photoreceptor Mosaic Using a Confocal Adaptive Optics Scanning Ophthalmoscope

Noninvasive Imaging of the Human Rod Photoreceptor Mosaic Using a Confocal Adaptive Optics Scanning Ophthalmoscope

... interleaved rod and cone ...by retinal disease ...the photoreceptor mosaic taken at 10° temporal to the ...blue cells in panel ...(green cells, panel c), indicating that even at this ...

22

Synchronizing multiphasic circadian rhythms of rhodopsin promoter expression in rod photoreceptor cells

Synchronizing multiphasic circadian rhythms of rhodopsin promoter expression in rod photoreceptor cells

... Retinal slices were transferred to the recording chamber on the microscope stage, and were allowed to settle for 30·min before light (room fluorescent light) or drug (e.g. dopamine, dopamine receptor agonist or ...

9

Retinal stem cells and regeneration

Retinal stem cells and regeneration

... has rod precursor cells in the outer nuclear layer (Johns and Fernald, 1981) and quiescent stem cells in the inner nuclear layer throughout the retinal circumference (Julian et ...these ...

12

Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

... Recent groundbreaking studies suggest that the bromodomain and extraterminal domain (BET) family of epigenetic “readers” is a powerful regulator in pathogen- esis involving inflammation [9–11]. For BET family proteins, ...

15

Show all 10000 documents...

Related subjects