Retinoid X Receptors
Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells.
... replication. Retinoid signals are mediated by specific nuclear receptors that belong to the steroid/thyroid hormone receptor ...The retinoid receptors are grouped into two sub- families ...
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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
... that retinoid X receptors (RXRs) are key elements of the transcriptional program of differentiating ...RXR/liver X receptor (LXR) heterodimers, which induced expression of sterol regulatory ...
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Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid
... and retinoid X receptors, PPARγ and RALDH-2 in bovine cumulus granulosa ...endogenous retinoid receptors are competent to bind the ligand and may be capable of transducing the ...
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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
... Liver X receptors; MMP-9: Matrix metalloproteinase-9; NF- κ B: Nuclear factor- κ B; NRs: Nuclear receptors; PBS: Phosphate buffered saline; PPARs: Peroxisome proliferator-activated receptors; ...
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Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers
... different receptors, such as thyroid hormone receptor (TR), glucocorticoid receptor (GR), mineralocorticoid receptor (MR), progesterone receptor (PR), retinoid X receptors (RXRs), ...
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Computational study of the potential molecular target for antibreast cancer activity of limonoid derivatives from chisocheton sp
... (Retinoid X Receptor Beta, RXRβ), 5MKU (Retinoid X Receptor Alpha, RXRα), 1SJ0 (Estrogen Receptor Alpha, ERα), 1QKM (Estrogen Receptor Beta, ERβ), 2LBD (Retinoic Acid Receptor Gamma, RARγ), ...
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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
... Partially inspired by early genetic studies (17–19) that defined noncardiomyocyte requirements of RXRA during mammalian cardiac morphogenesis, we systematically assessed the functions[r] ...
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Liver X receptors as integrators of metabolic and inflammatory signaling
... The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated in ...
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Liver X receptors regulate adrenal cholesterol balance
... liver X receptors (LXRa and LXRb) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes involved in all aspects of cholesterol utilization, including the ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... Retinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of cancer development and ...
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Studies of the expression and function of the retinoid-x-receptor y gene in rodent embryonic development
... with tRA activates transfected R X R a to drive transcription of an R X R a - d r iv e n reporter gene (Heyman et al., 1992; Levin et al., 1992), whereas no effect was observed in yeast cells (Mak et al., ...
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All trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor dependent signaling pathway
... of retinoid nuclear receptors, we found that a RAR-selective retinoid inhibited the growth of normal HBE ...- x –dependent signaling pathways (57, ...selective retinoid TTNPB, the ...
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Bench to bedside review: Ventilation induced renal injury through systemic mediator release just theory or a causal relationship?
... interleukin-1 receptor antagonist; iNOS, inducible nitric oxide synthase; I/R, ischemia/reperfusion; KC, keratinocyte chemoattractant; LXR, liver X-receptor/ retinoid X-receptor; MCP, mo[r] ...
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A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
... acid receptors. Unlike peptide- or protein-binding receptors that are located on the cellular membrane, NRs are intracellular and bind to their cognate hormones either in the cytoplasm (steroid hormones) or ...
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Retinoid protection against x ray induced chromatid damage in human peripheral blood lymphocytes
... study, x-ray-induced chromatid damage in PHA-stimulated blood lymphocytes from five XP patients receiving isotretinoin was approximately half that in blood samples from the same patients before or subsequent to ...
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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
... The levels of IL-5 and IL-13 in the culture supernatant in OVA-re-stimulated lung MNCs isolated from OVA-sensitized and -challenged mice were significantly suppressed in OVA/OVA/NEt-4IB [r] ...
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The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers
... and retinoid receptors, acti- vated by fatty acids and derivatives [21] and modulated by metabolic disorders [67] in establishing a link between overweight prevalence and CRC ...nuclear receptors may ...
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Yin, Shuai (2018): Targeting retinoid receptors with dysregulated microNRAs in pancreatic duct adenocarcinoma. Dissertation, LMU München: Medizinische Fakultät
... of retinoid receptors in PDAC, Pettersson et al have shown that activation of RAR could cause apoptosis in PDAC cells (Pettersson et al, ...of retinoid receptor in ...
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Cholesterol Metabolism and Its Regulation by Functional Foods
... these receptors in metabolism range from peroxisomal proliferation, increment in fatty acid oxidation, reduction in plasma triglyceride levels, and improvement in glucose ...
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