rheumatoid arthritis fibroblast-like synoviocytes
Methotrexate inhibits effects of platelet derived growth factor and interleukin 1β on rheumatoid arthritis fibroblast like synoviocytes
... in fibroblast-like synoviocytes ...b Rheumatoid arthritis (RA) FLS were stimulated with platelet-derived growth factor (PDGF, 20 ng/mL) + IL-1 β (2 ng/mL) for 24 h in the presence or ...
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Endoplasmic reticulum stress cooperates with Toll like receptor ligation in driving activation of rheumatoid arthritis fibroblast like synoviocytes
... in rheumatoid arthritis (RA), only a fraction of disease sus- ceptibility can be explained by genetic variation [1], and the temporal link between the break of self-tolerance and development of clinical ...
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ADAM 17 is expressed on rheumatoid arthritis fibroblast like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion
... elevated expression of both hypoxia inducible factor-1 and TNF-α in mice [24]. Ohta et al. also reported that ADAM-17 on RA STs was stronger than that on OA STs by immunohistochemistry. In addition, they showed that ...
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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... in rheumatoid arthritis fibroblast-like synoviocytes Next, to evaluate whether adiponectin stimulates the produc- tion of VEGF and MMPs for angiogenesis of pannus and joint destruction ...
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Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... Celecoxib does not induce caspase activation in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs). (a) FLSs were stimulated for 2 hours with celecoxib at indicated ...
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Resistin upregulates chemokine production by fibroblast like synoviocytes from patients with rheumatoid arthritis
... Methods: The expression of resistin and adenylate cyclase-associated protein 1 (CAP1), a receptor for resistin, was examined immunohistochemically in synovial tissue. CAP1 expression in in vitro cultured ...
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Innate immunity triggers IL 32 expression by fibroblast like synoviocytes in rheumatoid arthritis
... Figure 1 Effect of IFN-γ 0.1 ng/ml on IL-32 mRNA expression and IL-32 release by rheumatoid arthritis RA fibroblast-like synoviocytes FLSs.. e IL32 release in culture supernatants was de[r] ...
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MLN51and GM CSF involvement in the proliferation of fibroblast like synoviocytes in the pathogenesis of rheumatoid arthritis
... Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unclear ...RA fibroblast-like synoviocytes (FLSs) from patients with ...
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Glucose 6 phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast like synoviocytes in rheumatoid arthritis
... Several hypotheses have been proposed to explain ele- vated GPI antigen in the serum and SF of RA patients. The hypoxic microenvironment was considered to be one of the major factors contributing to GPI overexpression. ...
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Original Article Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
... [21, 22]. However, the role of DCK in the patho- genesis of RA has not been explored. The goal of this study was to investigate the role of DCK in regulating the migration and invasion of rheumatoid ...
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Effects of inflammatory cytokine IL 27 on the activation of fibroblast like synoviocytes in rheumatoid arthritis
... induced arthritis when administered at the onset of the disease via the blocking of Th17 differentiation from naïve T helper cells ...adjuvant-induced arthritis in vivo ...
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Different expression of β subunits of the KCa1 1 channel by invasive and non invasive human fibroblast like synoviocytes
... Background: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the ...
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Long noncoding RNA expression profile in fibroblast like synoviocytes from patients with rheumatoid arthritis
... Interestingly, strong associations between ENST0000 0483588 expression and the CRP level and SDAI score in patients with RA were found. CRP is an important clinical parameter that is commonly used as a marker of disease ...
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A novel function of artesunate on inhibiting migration and invasion of fibroblast like synoviocytes from rheumatoid arthritis patients
... Benefiting from advances in our understanding of RA pathogenesis, numerous efficacious agents for RA treat- ment are presently available with the application of biological agents and targeted synthetic DMARDs (tsDMARDs) ...
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The Effect of Serum Carrying Total Flavonoids of Rhizoma Drynariae on the Proliferation and Apoptosis of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
... Keywords: Rheumatoid Arthritis; Synovial Inflammation; Fibroblast; Rhizoma Drynariae Abbreviations: RA: Rheumatoid Arthritis; FLSs: Fibroblast-Like Synoviocytes; ...
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Akt activity protects rheumatoid synovial fibroblasts from Fas induced apoptosis by inhibition of Bid cleavage
... Cultured rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) were transfected as indicated in Figure 4 and treated for 12 hours with 100 ng/ml mFasL or pretreated for one hour ...
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Fibroblast activation protein is expressed by rheumatoid myofibroblast like synoviocytes
... Apart from the detection of FAP-positive FLSs in RA and OA, substantial differences between both diseases regarding this cell type are apparent. First, FAP-expressing FLSs in RA syn- ovial tissue are more frequent and ...
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The GTPase Rac Regulates the Proliferation and Invasion of Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients
... Whereas the signaling pathways that mediate the role of Rac proteins in the control of RA-FLS proliferation remain to be identified, in this work we focused more on the mechanisms that are respon- sible for Rac-regulated ...
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Anti inflammatory and antiarthritic effects of piperine in human interleukin 1β stimulated fibroblast like synoviocytes and in rat arthritis models
... Black pepper (Piper nigrum) is commonly used as a spice in human diets, but it is also used as a medicine, a preservative, and a perfume in many Asian countries. An extract of the active phenolic component, piperine, is ...
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RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast like synoviocytes
... attenuates arthritis [17]. Genetic deletion of CD44 increases arthritis severity, but block- ing RHAMM function attenuates arthritis suggesting that RHAMM possibly compensates for genetic loss of ...
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