Rheumatoid arthritis synovial fibroblasts
MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts
... osteoarthritis synovial fibroblasts; RASF, rheumatoid arthritis synovial fibroblasts; SAH, S-adenosyl homocysteine; SAM, S-adenosyl methionine; SSAT, spermine/spermidine ...
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TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
... 1 Rheumatoid arthritis synovial fibroblasts exhibit acute endoplasmic reticulum ...(a) Synovial fibroblasts from patients with rheumatoid arthritis (RA) were ...
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Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL and TRAIL induced apoptosis is cell cycle dependent
... apoptosis than RASFs that were arrested in G 0 /G 1 phase. These results suggest an inverse correlation between cell pro- liferation and apoptosis. However, how the proliferation influ- ences TRAIL- and FasL-mediated ...
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Original Article Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts
... Activated synovial fibroblasts in rheumatoid arthritis (RASF) play a critical role in the pathology of rheuma- toid arthritis ...in synovial tissue samples of RA patients as well ...
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Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... Celecoxib does not induce caspase activation in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs). (a) FLSs were stimulated for 2 hours with celecoxib at indicated concentrations or for 4 hours ...
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Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints
... Fig. 1 Cartilage coincubation with interleukin (IL)-1 stimulates transmigration of human tumor necrosis factor – transgenic (hTNFtg) synovial fibroblasts (SFs). a Schematic overview showing a modified ...
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Constitutive upregulation of the transforming growth factor β pathway in rheumatoid arthritis synovial fibroblasts
... to fibroblasts in synovial regions with pronounced fibrosis provides evidence for a pro-fibrotic role of TGF-β1 in RA ...lagen-induced arthritis [23] suggests TGF-β1 has an important pro-destructive ...
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Cells of the synovium in rheumatoid arthritis Synovial fibroblasts
... The primary extracellular stimulus for fibroblasts is fibroblast growth factor (FGF). RASFs not only proliferate in response to FGF but they are also part of an autocrine loop by producing FGF themselves, ...
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Original Article MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38MAPK signaling pathway
... Abstract: Rheumatoid arthritis is an autoimmune disease characterized as joint synovial ...in rheumatoid arthritis. Synovial fibroblasts isolated from rheumatoid ...
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Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
... activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid ...activation, rheumatoid arthritis synovial ...
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Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
... The aim of this study was to explore the molecular profile of proliferating rheumatoid arthritis synovial fibroblasts (RA-SF). Total RNA was extracted from two cultures of RA-SF (low- density ...
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Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL 1β/TNF
... Our report adds more information on human subjects with OA and RA. All clock proteins are ubiquitously present in synovial cells of these patients and in trauma controls (all cells are positive). It seems that ...
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Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
... that synovial senescent SF accumulation occurs progressively along normal aging, from relatively early ages, and preceding the age of peak prevalence of ...
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Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts
... The association of GusB activity with SF-derived MVs sheds light on a previously unrecognized localization of this enzyme. Innate immunity plays a key role in the initiation of an immune response. Its germline encoded ...
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MicroRNA-126 affects rheumatoid arthritis synovial fibroblast proliferation and apoptosis by targeting PIK3R2 and regulating PI3K-AKT signal pathway
... Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and destruction of the joints as well as an increased risk of cardiovascular ...RA synovial fibroblasts ...
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Differential Toll like receptor dependent collagenase expression in chondrocytes
... Introduction Rheumatoid arthritis is a chronic inflammatory disorder that primarily affects the joints and results in the destruction of cartilage and subchondral bone by the inflamed ...vitro, ...
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Cytokine mRNA and protein expression in primary culture and repeated passage synovial fibroblasts from patients with rheumatoid arthritis
... cells, fibroblasts, and bone- marrow stroma cells, activates cell proliferation, cytotoxity, and cytokine production in natural killer cells and is a potent chemoattractant for T ...isolated synovial tissue ...
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Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis
... RA synovial fibroblasts as shown here for ECs and found that they signal through *pP38, *pJnk, *pJak2 and *pNF-κB in response to Id1 (data not shown), thus providing further evidence that Id1 may induce ...
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Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis
... sive arthritis is not altered in FAK-deficient ...of arthritis is not ...for arthritis and joint ...in rheumatoid synovial fibroblasts (Figure ...
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mTOR Regulates the Invasive Properties of Synovial Fibroblasts in Rheumatoid Arthritis
... DA (blood type D, Agouti) rats with minimally invasive FLS from arthritis- protected DA rats with DA.F344(Cia5d) congenics led to the identification of an invasion-associated signature (9). This ...
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