rheumatoid synovial fibroblasts
Kinesin like protein CENP E is upregulated in rheumatoid synovial fibroblasts
... in rheumatoid synovial ...in rheumatoid synovial fibroblasts, codes for a kinesin-like motor protein named CENP-E, which was first characterized in ...
10
Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
... human synovial membrane isolated from healthy indi- viduals and patients with established ...healthy synovial tissue ...by fibroblasts in the sub-lining layer ...perivascular fibroblasts. ...
11
Constitutive expression of a 92 kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines
... Synovial fibroblasts freshly isolated from the rheumatoid joint are characterized by their marked connective tissue degradative ...lung fibroblasts and is immunologically cross-reactive with a ...
8
Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis
... There are several possible reasons why inflammatory ero- sive arthritis is not altered in FAK-deficient mice. First, al- though we observed that depletion of FAK was quite good, there may still have been some residual ...
10
Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity
... from rheumatoid synovial ...synovial fibroblasts. More recently, the interaction between synovial fibroblasts and HA via intracellular adhe- sion molecule-1 (ICAM-1) was reported ...
5
Characterization of the interaction between monocytes and synovial fibroblasts in rheumatoid arthritis
... the fibroblasts-like synoviocytes) and contains large amounts of rough endoplasmic reticulum with few cell processes and vacuoles, but more developed nucleoli indicating protein synthesis (Cutolo et ...normal ...
170
RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
... With the advent of next generation DNA sequencing technologies [9], such as RNA sequencing (RNA-seq), a more comprehensive and accurate transcriptome analysis has become feasible and affordable. In RNA-seq, short ...
16
Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... Celecoxib does not induce caspase activation in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs). (a) FLSs were stimulated for 2 hours with celecoxib at indicated concentrations or for 4 hours with ...
11
Synovial fibroblasts in 2017
... analysing synovial fibroblasts and their role in arthritis ...that synovial fibroblasts are critical in promoting destructive arthritis and produce a variety of factors that drive joint ...
10
Original Article Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts
... Changes of the expression of repellent factors, i.e., Netrins and their receptors, may be respon- sible for the invasive behavior of the synovial tissue cells in patients with RA [4, 13, 14]. RASF are known to ...
11
Identification of a high affinity receptor for interleukin 1 alpha and interleukin 1 beta on cultured human rheumatoid synovial cells
... human rheumatoid synovial cells is measured and compared to the concentrations of these mediators required for stimulation of PGE2 production by these same ...
8
Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis
... RA synovial fibroblasts as shown here for ECs and found that they signal through *pP38, *pJnk, *pJak2 and *pNF-κB in response to Id1 (data not shown), thus providing further evidence that Id1 may induce ...
12
Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL 1β/TNF
... Typically, quantitative PCR is used to study undulation of molecular clock mRNA over three days [15], which was also employed in the present study. After serum shock synchronization, synovial fibroblasts ...
12
Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients
... in synovial fibroblasts (SFBs) isolated from rheumatoid arthritis (RA) patients was studied by modeling the response to 4 external stimuli (IL-1β , TNF-α, TGF-β , and ...invasive synovial mem- ...
14
Constitutive upregulation of the transforming growth factor β pathway in rheumatoid arthritis synovial fibroblasts
... early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide microarrays; mRNA/protein data were validated by quantitative PCR (qPCR) ...
11
Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints
... Fig. 2 Tissue extravasation of intravenously injected 1,1 ′ -dioctadecyl-3,3,3 ′ ,3 ′ -tetramethylindotricarbocyanine iodide – labeled human tumor necrosis factor – transgenic (hTNFtg) synovial fibroblasts ...
11
Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts
... both synovial fibroblasts and synovial membrane ...both rheumatoid arthritis and osteoarthritis derived synovial ...by synovial membranes and synovial fibroblasts ...
13
Original Article MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38MAPK signaling pathway
... to synovial fibro- blasts and found that, compared with the con- trol group, miR-451 can obviously reduce p38 MAPK protein expression in synovial fibro- ...
6
Slit3 inhibits Robo3 induced invasion of synovial fibroblasts in rheumatoid arthritis
... dermal fibroblasts gain an aggressive phenotype after expression of ...by synovial lining cells and are responsible for matrix ...degradation. Synovial fluids of RA patients contain about 100-fold ...
9
Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
... in synovial tissues from patients with RA rather than from normal individuals (see Supple- mentary material), suggesting that these genes could con- tribute to the pathogenesis of ...
7