RNA Editing
RNA editing of human microRNAs
... double-stranded RNA (dsRNA) stem-loop formed between the miRNA sequence and its adja- cent complementary ...nucleotide RNA hairpin ...site. RNA editing is the site-specific modification of an ...
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Whole plastid transcriptomes reveal abundant RNA editing sites and differential editing status in Phalaenopsis aphrodite subsp. formosana
... mitochondrial RNA editing sites are abundant and highly variable, with approximately 189–635 edits in angiosperms (Bentolila et ...plastid RNA edits are relatively limited, with 21–44 nucleotide ...
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Abundant and Selective RNA-Editing Events in the Medicinal Mushroom Ganoderma lucidum
... using RNA-Seq data is one of the major challenges of accurate RNA-editing ...of RNA-editing ...Illumina RNA-Seq data, followed by multiple filter- ing steps, provided high ...
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A New Ebola Virus Nonstructural Glycoprotein Expressed through RNA Editing
... RNA editing is one of the evolutionary mechanisms allowing a fairly compact RNA virus to optimize its coding ...with RNA editing sites encode structural and nonstruc- tural proteins ...
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RNA Editing in Hepatitis Delta Virus Genotype III Requires a Branched Double-Hairpin RNA Structure
... RNA editing at the amber/W site plays a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produce two functionally distinct forms of the sole viral protein, ...
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Regulation of Ion Channel and Transporter Function Through RNA Editing
... new RNA editing sites arising from adenosine ...of RNA editing sites in the human brain transcriptome, although only a small fraction of these are in open reading frames and recode amino acids ...
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RNA editing generates cellular subsets with diverse sequence within populations
... Specific RNA-editing events found from RNA-seq are typically presented in the literature with their detected editing rates, that is, the number of edited reads divided by the total number of ...
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The challenge of target sequence specificity in C→U RNA editing
... C→U RNA editing is mammalian apoB mRNA, in which a site-specific cytidine deamination introduces a UAA stop codon into the translational reading frame, result- ing in synthesis of a truncated protein, ...
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Activity-Dependent A-to-I RNA Editing in Rat Cortical Neurons
... dependent editing, such as glutamate and serotonin receptor subunits, defects in editing have been implicated in common nervous system disorders, including epilepsy, amyotrophic lateral sclerosis, and ...
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Population and allelic variation of A to I RNA editing in human transcriptomes
... between RNA editing and GWAS signals GWAS have had much success in associating genetic variants with human traits and ...of RNA editing may underlie the association between certain GWAS ...
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ADAR1-mediated RNA-editing of 3′UTRs in breast cancer
... RNA editing is not uniformly distributed along the transcripts, showing a large number of edited sites at intronic and 3 ′ UTR regions [4, 19, 20], Similarly, we found a large number of edited sites at ...
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Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing
... identify RNA editing sites in the brain, subcutaneous fat, heart, liver, muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome ...
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Effects of Conserved RNA Secondary Structures on Hepatitis Delta Virus Genotype I RNA Editing, Replication, and Virus Production
... RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication ...cycle. Editing is required ...
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Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing
... (A-to-I) editing is frequently observed in meta- zoan transcripts and represents a potentially important mechanism for facilitating advantageous molecular diversification in ...of RNA editing has ...
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Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system
... that RNA editing might play a role in ALS. Editing at the Q/R position in GluR-B of spinal motor neurons from ALS patients were severely decreased, ranging from 62–100%, whereas all normal control ...
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Gene Loss and Error Prone RNA Editing in the Mitochondrion of Perkinsela, an Endosymbiotic Kinetoplastid
... undergoing RNA editing are shown in ...of RNA editing in these ...strand-specific RNA-seq reads (with U-indel optimized settings) for each transcript is shown in the sense orientation ...
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Massive A to I RNA editing is common across the Metazoa and correlates with dsRNA abundance
... their editing activity in a wide panel of animals, looking at clusters of RNA editing ...that editing is observed in all species ex- pressing ADARs, but its abundance varies ...extensive ...
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A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
... For the mouse study, heterozygous Adar2 knockout mice ( Adar2 +/− (n = 10) and the WT littermates (n = 10) were used for the RNA editing analysis by pyrosequencing [43]. Each group included five males and ...
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A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock
... A-to-I RNA editing is common to all metazoans and is a very abundant modification of the transcriptome ...A-to-I RNA editing can recode the transcriptome by substituting amino acids [9,10] and ...
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TbMP44 Is Essential for RNA Editing and Structural Integrity of the Editosome in Trypanosoma brucei
... RNA editing in the mitochondria of kinetoplastid protozoa is a form of RNA processing that occurs by a series of enzy- matic steps and results in mature mRNAs ...by RNA ligase to complete one ...
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