RNA processing and the DNA damage response
C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response
... of RNA polymerase II transcription. The need for the surveillance of RNA quality is also proportionally increased at these highly transcribed regions, particu- larly at sites hosting repetitive ...of ...
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Characterisation of CIP29:a potential target of the eukaryotic DNA damage response
... certain DNA repair pathways such as ...promotes DNA damage repair, and helps stabilize stalled replication forks (Cimprich & Cortez, ...in RNA processing, as a regulator of mRNA ...
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RNA interference to enhance radiation therapy: targeting the DNA damage response
... The Ku proteins could also be potential therapeutic RNAi targets as critical mediators of early NHEJ. Currently no small molecule inhibitors have been demonstrated to have inhibitory activity against these proteins. ...
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DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response
... molecule DNA intercalator, BMH- 21, that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) ...Despite DNA intercalation, BMH-21 does not cause phosphorylation of H2AX, a key biomarker ...
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Scorpins in the DNA Damage Response
... complex raises the question whether Scorpins determine protein turnover of important players of the DNA repair. On a more basic level, the clinical relevance of Scorpins expression/protein levels still requires ...
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Autophagy in DNA Damage Response
... in response to mitochondrial depolarization, these mitochondria are marked for degradation by ubiquitination of this mitochondrial protein by the E3 ligase Parkin ...mtDNA damage can trigger mitophagy in an ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... SOS DNA damage response without a requirement for DNA ...following DNA damage and RecA* ...NTD DNA-binding and CTD protease activities while acquiring the novel function ...
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Phosphatases in the cellular response to DNA damage
... The data discussed here seems to reveal a scenario where multiple phosphatases target the same phosphor- ylation events. While this could be construed as exces- sive promiscuity of phosphatases we believe that a more ...
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The Smc complexes in DNA damage response
... mediate DNA repair are not ...their DNA repair functions are separ- able from their major functions in sister-chromatid cohesion and chromosome ...the DNA repair func- tions of the Smc complexes are ...
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New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing
... Therefore, we investigated whether Nek4 could modu- late the splicing site selection of the adenoviral E1A mini- gene, a common assay to verify in vivo splicing regulation. Depending on the 5’-splice site selection, the ...
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Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase
... Gene expression is dynamic process, tightly regulated and highly responsive to the cellular milieu. Occurring at every stage of the process, regulation of gene expression may be facilitated by proteins, RNA, and ...
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Ciliogenesis and the DNA damage response: A stressful relationship.
... the DNA damage response (DDR), and genome stability mechanisms involve a complex net- work of signalling and processing factors that ensure redundancy and adaptability of these ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... damaged DNA will enter cell cycle and mutations will accumulate at higher rate in the ...in response to DNA damage may be a potential therapeutic target to be explored to control ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... Inter-strand crosslinks can be induced by exposure to alkylating agents, platinum and psoralens in environment and by clinical treatments and they are toxic to cells given that they strongly prevent transcription and ...
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DNA-PK suppresses a p53 independent apoptotic response to DNA damage
... of DNA-PK does not rescue all modes of p53 dependent apoptosis, but is specific to DNA damage initiated ...DISCUSSION DNA-PK is not required for the canonical p53 mediated apoptotic ...
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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
... and DNA-PK as potential therapeutic agents As the DDR can be activated at early stages in tumorigenesis due to oncogene-induced replication stress or processes such as telomere shortening, this has suggested that ...
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The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.
... the DNA damage marker ...quantifies DNA repair, and found that OSU-CLL expressing treRNA had markedly reduced induction of DNA damage after one hour exposure to fludarabine, ...
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Unraveling functions of the Arabidopsis histone deacetylase HDA6 in RNA-mediated silencing, DNA damage response and plant development
... of RNA-directed DNA methylation (RdDM), suggesting that HDA6 might have acquired specific functions for transcriptional silencing processes mediated by small interfering RNAs ...that DNA methylation ...
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ATP-dependent chromatin remodeling in the DNA-damage response
... on DNA of nucleosome occupancy, the loss of which results from DNA damage and its repair, may also require ATP-dependent chromatin ...synthesized DNA as well ...alternative DNA ...
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Nuclear Localization of p38 MAPK in Response to DNA Damage
... in response to DNA damage stimuli re- quires phosphorylation of Thr 180 /Tyr 182 by MKK3 and/or MKK6, but it does not require its catalytic ...in response to DNA damage, but not ...
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