RXR, retinoid X receptor
A retinoid X receptor (RXR) selective retinoid reveals that RXR α is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator activated receptor ligands
... the RXR-selective ligand AGN194204 altered expression of a larger group of genes, including those encoding growth factor receptors, mitogen-activated protein kinases, cyclins, and ...factor receptor and the ...
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: House dust mite; Ag: Antigen; APC: Antigen presenting cells; TCR: T cell receptor; ...
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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
... conditions. Given that ATRA primarily binds to retinoic acid recep- tors (RARs), the cardioprotective effects of RA activation have been generally attributed to RARs. Nevertheless, recent studies also prompted the ...
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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
... However, RXR full agonists are associ- ated with strong adverse events, including the elevation of blood triglycerides, hepatomegaly and hypothyroidism [12, ...novel RXR partial agonist that displays no ...
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Retinoid X receptor and peroxisome proliferator activated receptor gamma agonists cooperate to inhibit matrix metalloproteinase gene expression
... the RXR ligand LG268 specifically inhibit MMP-1 and MMP-13 gene expression in IL-1-stimulated chondrocytic ...both RXR and PPAR leads to additive inhibi- tion of MMP-1 and MMP-13 production, suggesting ...
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... Tissues from patients with breast cancer or lung cancer were retrospectively identified from the surgical pathology files of Wuhan General Hospital of Guangzhou Command (Wuhan, PR, China). Pathology slides were analyzed ...
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Studies of the expression and function of the retinoid-x-receptor y gene in rodent embryonic development
... to RXR but not RARs (Mangelsdorf et ...preferred receptor dim ers which should bind to uncharacterised ...of receptor dimers may recognise different HREs and that factors other than h alf-site ...
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Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor Heterodimers
... pADH1_RXR_2A_NLS_GAL4AD_RAR.pSUR (Gene Bank AB425277) was constructed previously and used as a reporter in the modified yeast one-hybrid system [8]. The positive control of a modified one-hybrid assay were constructed by ...
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Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
... estrogen receptor, progesterone receptor and/or ...D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor γ (PPAR γ ) are known ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... of RXR a to full-length enhancer 1 containing the same point ...with RXR a ...an RXR a -PPAR het- erodimeric complex interacts with the HBV ...
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The retinoid X receptor from mud crab: new insights into its roles in ovarian development and related signaling pathway
... other RXR/USPs from both vertebrates and invertebrates showed that all the three SpRXR isoforms had a high homology to RXRs of other crustaceans and possessed the typical domain organization of nuclear hormone ...
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Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures
... the RXR ␣ ligand- binding domain and efficiently stimulate RXR ␣ (50, ...activating RXR ␣ (even if only partially) and whether there is a positive feedback loop between RXR ␣ activity and AA ...
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Computational systems pharmacology and docking explored diosgenin targets causal and effectors pathogenic signalling network of vascular calcification
... D receptor (VDR) which is an important regulator of vascular ...D receptor (VDR)-mediated transcription by suppressing the ligand-activated VDR/RXR heterodimer is expected be of therapeutic value in ...
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Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
... RXR isotype affects SMRT interaction with the PPARγ-RXR heterodimer. We hypothesized that the observed increase in PPARγ-RXRβ respon- siveness to agonist could result from a specific feature of the RXRα- ...
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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
... acid receptor (RAR), and the associated ligands play critical roles in the generation of the ...of retinoid binding protein and ret- inoic acid binding protein are observed during the peri- natal period ...
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An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro
... an RXR-like ...mammalian RXR were used to target worm viability in vitro. HX630 is an RXR agonist which can bind to RXR and also to nuclear hormone heterodimers, which include RXR as a ...
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Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula
... domuncula RXR, RXR_SUBDO, with the related sequences from the coral Acropora millepora nuclear receptors TLL (TLL_ACROMI; AF323680), NR7 (NR7_ACROMI; AF323687) and NR8 (NR8_ACROMI; AF323688), Cnidaria Tripedalia ...
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Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation
... liver X receptors [16], retinoid X receptor (RXR) [17], farnesoid X receptor [18], and per- oxisome proliferator-activated receptors (PPARs) [19], resulting in an altered ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... or retinoid X receptor-alpha (RXR-alpha) and a chloramphenicol acetyl transferase (CAT) reporter plasmid containing a retinoic acid responsive element into CV-1 cells was used to determine the ...
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Retinoid X Receptor Antagonists
... as RXR modulators. 41 Although these compounds showed RXR activity in mammalian one-hybrid assay using Gal4-DBD- RXR-LBD, they showed antagonist activity in reporter assay using full-length ...
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