SCFR, the stem cell factor receptor, the product of the c-kit gene
The role of stem cell factor and of alternative c kit gene products in the establishment, maintenance and function of germ cells
... the receptor to the plasma ...the c-kit- mediated ...the receptor and activation of the intrinsic tyrosine kinase activity of the receptor ...by c-kit or serve as adaptor ...
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Glucocorticoids decrease tissue mast cell number by reducing the production of the c kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems
... (Amersham, Arlington Heights, IL). After in vitro transcription, the DNA template was digested with RNase-free DNase I. The probe was then purified with a 7 mol/liter urea/6% polyacrylamide gel (Na- tional Diagnostics, ...
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The structural insights of stem cell factor receptor (c Kit) interaction with tyrosine phosphatase 2 (Shp 2): An in silico analysis
... activated c-Kit, the residues Lys818 and Asn819 make intermolecular hydrogen bonding with N-sh2 domain residues “Tyr100 and Ser28” as a result of the disruption of intramolecular hydrogen bonding with ...
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Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro
... necrosis factor (TNF) and lymphotoxin α, which are important contributing factors to suppression of β-cell function and subsequent apoptosis in type 1 diabetics (Kagi et ...insulin gene expression ...
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Is c-kit Gene Product involved in Epithelial- Mesenchymal Transition in Tongue Squamous Cell Carcinoma? A Pilot Study Oriented Towards Patient Outcome
... the c-kit juxtamembrane domain (exon 11) and tyrosine kinase domain (exon 17) during the process of malignant ...aberrant c-kit transcript mRNAs has been observed in various cancer cell ...
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Stem cell factor and its soluble receptor (c-kit) in serum of asthmatic patients- correlation with disease severity
... Data are presented as mean ± standard error mean. For comparison of 3 groups of variables Kruskal Wallis ANNOVA and post hoc Dunn tests were used. For com- parison of 2 variables nonparametric unpaired 2-group test ...
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Efficient c-kit Receptor-Targeted Gene Transfer to Primary Human CD34-Selected Hematopoietic Stem Cells
... virus receptor retargeting consistently showed a substantial reduction in (Epo receptor), or complete loss of (c-kit recep- tor), cellular transduction (15, 22, ...accomplish c- ...
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Hematopoietic stem cell emergence in the conceptus and the role of Runx1
... Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplan- tation into irradiated or otherwise immunocompromised adult organisms provide long-term reconstitution of the entire ...
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Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney
... APLP1 gene located distal to D19S610 did not show variations between patients and controls, and was excluded as the NPHS1 gene (Lenkkeri et ...and C containing 9, 5 and 3 exons, respectively, did not ...
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The clinical significance of the <em>Ezrin</em> gene and circulating tumor cells in osteosarcoma
... RNA-ISH was applied to investigate the expression of Ezrin in CTCs from 38 osteosarcoma patients. The results showed that Ezrin gene was expressed in ~ 77.85% of CTCs. Further research indicated that the ...
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Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature
... mesenchymal cell progenitor; it can develop as a novo lesion or secondary to radiation, surgery, osteonecrosis, Paget’s disease, fibrous dysplasia, among ...
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The Diagnostic Value of the P53 Tumor Marker as a Prognostic Factor in Patients with Squamous Cell Carcinoma of the Larynx
... cell cycle control pathway, which is caused by mutations of tumor antigens, is of great importance as well. Facture of the pathway by P53 brings about increased cell proliferation and genetic damages. ...
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The genetics and the molecular functions of the PREP1 homeodomain transcription factor
... transcription factor and a cofactor of Hox proteins belonging to the TALE (Three Amino acids Loop Extension) super class of the Homeobox proteins (reviewed in (Moens and Selleri, ...Hox gene expression ...
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The drumstick gene acts cell non autonomously and triggers specification of the small intestine in the Drosophila hindgut
... marker gene of the small intestine, is not expressed in the hindgut region at these stages ...homeobox gene specifically expressed in the large intestine, is first expressed in the hindgut primordium at ...
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The influence of the penetrating cryoprotectors on protein synthesis in the cell-free system of the rat liver
... Необходимо отметить, что после удаления ДМСО уровень биосинтеза протеинов не только возвращается к прежним значениям, но и превышает их на 33%, что, возможно, связано с влиянием дан[r] ...
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The developmental origins of the mammalian ovarian reserve
... As gene expression in the polar body closely reflects expression in the oocyte from which it derived, the polar body can act as a proxy when choosing oocytes for ...
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The Issues of the Judicial System and the Jurisdiction of the Courts of the First Instance in the Republic of Austria
... In the jurisdiction of general courts (ordentliche Gerichte) is related to the review of the civil and criminal cases as well as cases of public law. In the structure of the courts of [r] ...
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A Note on the Dichotomous Branching of the Main Stem of the Tomato (Lycopersicum esculentum)
... In order to decide definitely that the present example was not merely an apparently equal development of the main stem and of an axillary shoot a study of the anatomy was made. % indic[r] ...
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Honoring the work and life of Leroy C Stevens A symposium as part of the International Stem Cell Initiative Workshop
... national Stem Cell Initiative ...pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in ...
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From the spectrin gene to the assembly of the membrane skeleton
... Int ,J Ol'\ Riu\ ~3 49 54 (19S')) 49 From the spectrin gene to the assembly of the membrane skeleton VELI MATTI WASENIUS, MATTI SARASTE and VELI PEKKA LEHTO Df partrnent of Medical Chemistry Universit[.] ...
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