Schistosome infection
The C type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1 deficient mice have normal responses during schistosome infection
... in schistosome infection and intact egg excretion, there were no differences in plasma levels of AST ...of infection, with smaller-sized granulomas in both groups of mice in the chronic stages versus ...
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CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.
... Figure 1. Colonic granuloma size and fibrosis is reduced in the chronic phase of schistosome infection. A). Accumulation of eggs /gram of colon tissue (n = 4 mice/time point); mean eggs (6 SEM). B) ...
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Schistosome infection in deer mice (Peromyscus maniculatus): impacts on host physiology, behavior and energetics
... by infection may have impaired synthesis of ...nutrient. Schistosome worms and eggs (which grow and embryonate over ~9·days inside the host) absorb free amino acids (Bruce et ...
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Accuracy of point-of-care testing for circulatory cathodic antigen in the detection of schistosome infection : Systematic review and meta-analysis
... The WHO strategy for schistosomiasis control has been active case detection and treatment with praziquantel (PZQ). Mass treatment with no prior diagnosis is usually employed in high endemicity settings. 5 Kato-Katz thick ...
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Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia
... that schistosome infection status at seroconversion was correlated to the infection sta- tus at the last HIV-1 negative sero-survey and first HIV-1 positive ...with schistosome ...
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Parameters of the attenuated schistosome vaccine evaluated in the olive baboon
... A major problem that will need to be addressed in trials of human schistosomiasis vaccines is the impossibility of deter- mining worm burden directly as the measure of protection. We have, for the first time, evaluated ...
5
Infection with schistosome parasites in snails leads to increased predation by prawns: implications for human schistosomiasis control
... of schistosome parasitism on snail predation or on snail anti-predator ...whether schistosome-infected snails are eaten more or less frequently than uninfected snails by sympatric native prawn predators, ...
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Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity
... soil-transmitted helminthes do not influence the specificity of DDIA. The low specificity of DDIA could arguably be due to the well-known insensitivity of single stool Kato- Katz thick smears since the communities in ...
9
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo controlled trial
... of schistosome infection, levels of antibodies against schistosome antigens and prevalence of co-infec- tions such as hookworm, ...mansoni infection inten- sity, none of these factors was ...
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Elevation of C reactive protein, P selectin and Resistin as potential inflammatory biomarkers of urogenital Schistosomiasis exposure in preschool children
... between schistosome-positive or negative indi- viduals as determined by parasitology were analysed using the Mann-Whitney U ...with schistosome infection intensity or IgM response to CAP or ...to ...
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Genetic manipulation of Schistosoma haematobium, the neglected schistosome
... Methods/Findings: Here we isolated and cultured developmental stages of S. haematobium, derived from experimentally infected hamsters. Targeting different developmental stages, we investigated the utility of soaking ...
10
A role for peroxisome proliferator activated receptors in the immunopathology of schistosomiasis?
... In infection with the nematode Brugia malayi, AAMΦs are associated with Th-2 biasing [36, 37], while in infection with Heligmosomoides polygyrus, AAMΦs have a role in parasite clearance and host protection ...
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Schistosome Interactions within the Schistosoma haematobium Group, Malawi
... Abstract Genetic interactions occurring between human (Schistosoma haematobium) and livestock (S. bovis) schistosome species were revealed by molecular analysis of atypical schist[r] ...
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Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections
... C57BL/6NRj mice were orally infected with 200 embryo- nated T. muris eggs. At 42 days p.i., the feces were col- lected and soaked for 1 hour in 0.9% sodium chloride, before the filtered suspension was examined under the ...
10
Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis
... injection of three different doses of AuNPs and PZQ to infected mice increased the levels of MDA and NO sig- nificantly as compared to noninfected group. A significant reduction was observed in hepatic MDA and NO levels ...
9
A protease based biosensor for the detection of schistosome cercariae
... Parasitic diseases affect millions of people worldwide, causing debilitating illnesses and death. Rapid and cost-effective approaches to detect parasites are needed, especially in resource-limited settings. A common ...
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Monitoring and evaluating the impact of national school based deworming in Kenya: study design and baseline results
... The baseline surveys were conducted between January and April 2012. In each school, 18 children (9 girls and 9 boys) were sampled randomly from each of six clas- ses - one Early Childhood Development (ECD) class and ...
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Identification of Schistosoma mansonigender associated gene transcripts by cDNA microarray profiling
... of schistosome 18S rRNA ...the schistosome genomic DNA spots contained on the cDNA microarray in three representative independent experiments (Figure ...
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Whole genome amplification and exome sequencing of archived schistosome miracidia
... Exome capture methods are more expensive than other reduced representation library preparation approaches, such as RADseq (Harvey et al., 2016). However, exome capture targets specific genome regions of interest and in a ...
9
Targeting schistosome cholinesterases for vaccine and drug development
... 109 All SmChEs share a modest level of identity which is consistent with their divergence over evolutionary time, an occurrence possibly due to a series of gene duplications as each paralog’s clade is distant from one ...
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