SCID mouse
Human Prolactin Promotes Human Secondary Immunoglobulin Response in Human/SCID Mouse Chimeras
... huPBL-SCID mouse response to recall antigens suggest that PRL may be of poten- tial use as a B-cell adjuvant in vivo, particularly in promoting IgG ...
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Novel Endogenous Type D Retroviral Particles Expressed at High Levels in a SCID Mouse Thymic Lymphoma
... cultured SCID spleen and bone marrow in the PERT assay would support the presence of infrequent particles (data not ...a SCID mouse-derived thymocytic lymphoma, and we were in- terested in testing ...
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Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro
... a SCID mouse with primary readouts of cognitive dysfunc- tion measured by maze learning and pathological indices quantified with immunohistochemistry that included amounts of astrogliosis and mononuclear ...
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Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model
... NOD/SCID mouse infection model. We isolated a mouse-adapted EV71 strain [EV71(NOD/SCID)] that causes paralysis of the hind limbs in 3- to 4-week-old NOD/SCID mice by adaptation of the ...
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Herpetic stromal keratitis in the reconstituted scid mouse model.
... I One day after infection or sham infection, mice were given an adoptive transfer of various concentrations of unfractionated immune lymphocytes from donor BALB/c mice or splenocytes fro[r] ...
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Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis
... ABSTRACT Varicella-zoster virus (VZV) is the skin-tropic human alphaherpesvirus re- sponsible for both varicella-zoster and herpes zoster. Varicella-zoster and herpes zos- ter skin lesions have similar morphologies, but ...
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Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model
... Immunohistochemical staining of the tumors was performed to compare the amount of lytic EBV gene expression in LPD lesions derived from WT LCLs, Z-KO LCLs carrying the con- trol vector, or Z-KO LCLs carrying a BZLF1 ...
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Varicella-Zoster Virus Glycoprotein E Is a Critical Determinant of Virulence in the SCID Mouse-Human Model of Neuropathogenesis
... Aberrant expression of gE and gI in DRG infected with gE ⌬ Cys. We assessed the expression and subcellular localiza- tion of gE and gI in the absence of a gE/gI interaction by confocal immunofluorescent microscopy of DRG ...
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Identification and Characterization of Putative Secreted Antigens from Babesia microti
... infecting SCID mice likely shed or secrete proteins during their normal growth ...from SCID mice are collected and processed to remove cellular debris and any whole cells or parasites, the shed or secreted ...
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Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.
... in SCID mouse brain (but not intestine) after intraperitoneal inoculation, (ii) killed adult SCID mice faster than T3D, and (iii) grew well in neonatal NIH Swiss [NIH(s)] mouse brain tissue ...
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Osteoclast independent bone resorption by fibroblast like cells
... established SCID mouse model of matrix destruction ...the SCID mouse model indicates that activated fibroblast-like cells, compa- rable to those in RA, can also be found in ...
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Immunodeficient Mouse Models with Different Disease Profiles by In Vivo Infection with the Same Clinical Isolate of Enterovirus 71
... three mouse models for experimental infection with the same clinical isolate of ...NOD/SCID mouse model is unique for the development of skin rash, an HFMD-like ...
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The activin follistatin anti inflammatory cycle is deregulated in synovial fibroblasts
... the SCID mouse model, the invasive behavior of RASF overexpressing activin A was decreased compared to GFP controls, whereas the acti- vin A overexpression in IL-1β activated OASF did not influence the ...
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Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
... the SCID mouse model have shown that SF can migrate from the primary site of im- plantation to distant sites of exposed cartilage through the vascular system ...
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Gene therapy in rheumatoid arthritis: how to target joint destruction?
... though the activation of c-Jun. Despite an effect on the expression of c-Jun, as well as on the expression of MMP- 1 and MMP-13, however, invasiveness of RA-SFs was not inhibited completely in the SCID ...
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Expansion of human NOD/SCID repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL 6, and soluble IL 6 receptor
... Here, we demonstrate a significant ex vivo expansion of human hematopoietic stem cells capable of repopulating in NOD/SCID mice. Using a combination of stem cell factor (SCF), Flk2/Flt3 ligand (FL), thrombopoietin ...
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Cyclized Oligopeptide Targeting LRP5/6 DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model
... Purpose: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the ...
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Human Immunodeficiency Virus Type 1 IIIB Selected for Replication In Vivo Exhibits Increased Envelope Glycoproteins in Virions without Alteration in Coreceptor Usage: Separation of In Vivo Replication from Macrophage Tropism
... We further showed here that the infectious LW/C clone derived from the IIIB-infected laboratory worker (28), like HXB2/LW, replicated to high levels in the SCID-hu Thy/Liv mouse and HF-TOC models. As ...
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Schramm_unc_0153M_18601.pdf
... In immune competent mice, the inability of NS5 to inhibit murine STAT2 results in a strong type I IFN response, suppression of virus replication and control of ZIKV infection (38, 39). This is consistent with our results ...
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B cell lymphoma in hiv transgenic mice
... the mouse control FVB/N, Tg is an HIV Tg mice without skin lesions, mice number 18, 21, and 22 represent mice at the pre-lymphadenopathy stage while mice number 11, 20 and 35 represent mice at a late stage of ...
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