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selective COX – 2 inhibitor

ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX 2 INHIBITOR WITH CONVENTIONAL NSAIDs

ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX 2 INHIBITOR WITH CONVENTIONAL NSAIDs

... The selective cox-2 inhibitor has high effective than the conventional NSAIDs and has low gastrointestinal and high cardiovascular side effects than to the conventional ...a ...

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Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

... the selective COX-2 inhibitor, NS398 (N-[2-(Cyclohexyloxy)-4-nitrophenyl] methanesulfonamide) acquired from Sigma Aldrich (Sigma Aldrich, Saint Louis, MO, ...the COX-2 ...

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SYNTHESIS OF N (ALKYL OR ARYL) 2 (1H BENZOTRIAZOL 1 YL) ACETAMIDES AS SELECTIVE COX 2 INHIBITOR

SYNTHESIS OF N (ALKYL OR ARYL) 2 (1H BENZOTRIAZOL 1 YL) ACETAMIDES AS SELECTIVE COX 2 INHIBITOR

... GC-MS spectra & chromatogram were recorded on GCMS-QP 2010 SHIMADZU instrument. All solvents were distilled before use. All nonaqueous reactions were performed in dry glassware. All microwave reactions were carried ...

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NS 398 induces caspase dependent, mitochondria mediated intrinsic apoptosis of hepatoma cells

NS 398 induces caspase dependent, mitochondria mediated intrinsic apoptosis of hepatoma cells

... Regardless of concentrations of this compound applied in the present study, genomic DNA of Hep3B cells was fragmented as ladder-pattern at 48 h after the treatment of NS-398, which represented an apoptosis induced by ...

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The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

... and COX-2 knockout mice {Chikazu, 2007 ...of COX-2 was induced in bone surrounding the implants in wild-type mice, but not in COX-2 knockout mice and that the bone-to-implant ...

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QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors

QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors

... the COX-2 selective inhibitor NSAID drugs were thought to be a major breakthrough, with the Expectation of a significant reduction in gastrointestinal (GI) side ...effects. COX-2 ...

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BISPHENOL A ENHANCES GROWTH OF Hep G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS

BISPHENOL A ENHANCES GROWTH OF Hep G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS

... Akt, COX-2, HIF-1α and VEGF in the liver cancer ...a selective COX-2 inhibitor, Meloxicam, was found to decrease the expression of these proteins ...

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Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor

Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor

... a selective COX-2 inhibitor, in spite of the consti- tutive expression of the inducible isoform in the pan- ...non-selective COX in- hibitor, DFU did not induce severe ...

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Original Article Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells

Original Article Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells

... 7]. Selective COX-2 inhibitor celecoxib is commonly used as one of the non- steroidal anti-inflammatory drugs (NSAIDs) in ...tive COX-2 inhibitor celecoxib has been ...

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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk

Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk

... of COX-2 on platelets and the effect on overall platelet function are still matters of controversy ...only COX- 1, COX-2 can be readily induced under conditions of vascular injury ...of ...

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Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP

Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP

... a selective COX-2 inhibitor (22, 23), in the 2K1C model we administered it at days 5 and 6 of ...for 2 days, because SC-58125 adminis- trated at 20 mg/kg for 2 days had an ...

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Selective inhibition of cyclooxygenase (COX) 2 reverses inflammation and expression of COX 2 and interleukin 6 in rat adjuvant arthritis

Selective inhibition of cyclooxygenase (COX) 2 reverses inflammation and expression of COX 2 and interleukin 6 in rat adjuvant arthritis

... a selective COX-2 inhibitor to block PG production (23) and acute tissue inflammation (27) in vivo at dosages that do not affect stomach PG production, suggesting that COX-2 ...

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Perioperative celecoxib administration for pain management after total knee arthroplasty – A randomized, controlled study

Perioperative celecoxib administration for pain management after total knee arthroplasty – A randomized, controlled study

... a selective COX-2 inhibitor, reduced postop- erative VAS pain scores at rest and decreased morphine usage while providing better ROM rehabilitation ...

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Should selective Cox-2 inhibitors be used more?

Should selective Cox-2 inhibitors be used more?

... The unanticipated outcomes of several clinical studies raised a number of issues regarding the clinical efficacy and overall safety of selective coxibs. The important issue that has to be resolved is that the ...

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Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

... that selective COX-2 inhibition can attenuate MPTP-induced dopaminergic ...the COX-2 inhibitor are specifically related to COX-2, we conducted an analogous ...

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Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro

Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro

... both COX-1 and ...without inhibitor, four loaded with different concentrations of celecoxib and two loaded with different concentrations of indomethacin added to the ...of inhibitor concentrations in ...

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Original Article Anesthetic isoflurane reduces neuropathic pain by inhibiting IL-1β-induced COX-2 activation and CCL2 release in rat trigeminal ganglia cells

Original Article Anesthetic isoflurane reduces neuropathic pain by inhibiting IL-1β-induced COX-2 activation and CCL2 release in rat trigeminal ganglia cells

... ligand 2 (CCL2) in IL-1β-stimulated TGCs, as determined by quantitative real-time PCR and Western blot, ...E 2 (PGE 2 ), CCL2, and calcitonin gene-related peptide (CGRP) release from TGCs was ...

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The Role of Celecoxib as a Cox-2 Inhibitor Increasing the Radiosensitivity of Tumor Tissue

The Role of Celecoxib as a Cox-2 Inhibitor Increasing the Radiosensitivity of Tumor Tissue

... for COX-2, there might be other factors involved ...Z-DEVD-FMK inhibitor and prostaglandin E2.In contrast, BCL-2, bax, c-Myc, Fas and Fas-ligand showed minor ...of COX-2, which ...

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New functions for Cox 2 in health and disease: Report of “The Third International Workshop on Cox 2”, Ka’upulehu, Kona, Hawaii, USA, 30 August to 2 September 1999

New functions for Cox 2 in health and disease: Report of “The Third International Workshop on Cox 2”, Ka’upulehu, Kona, Hawaii, USA, 30 August to 2 September 1999

... the Cox enzymes has been known in principle for a few years, several function- ally important features still remain to be ...The Cox-2 enzymatic channel is wider than that of Cox-1, and it has ...

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Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients

Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients

... non selective NSAID and onset of symptoms ...non selective NSAID hypersensitivity may consequently lead to a lower estimate of the percentage of COX-2 inhibitor ...of ...

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