SET Domain and Histone methylation
Methylation of Histone H3 Lysine 36 Is Required for Normal Development in Neurospora crassa
... (e.g., methylation, acetylation, phosphorylation, and ubiquitylation) (51, ...influencing histone-DNA, histone-histone, and histone-non- histone protein interactions (16, ...of ...
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Histone methylation is required for oogenesis in Drosophila
... Drosophila ovaries consist of 15-20 ovarioles that hold egg chambers in progressive stages of development (Spradling, 1993). These egg chambers contain germ cells derived from germ stem cells located in the germarium, a ...
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Evaluation of MLL2 (KMT2B) Gene Expression in Colorectal Cancer Tissue Compared with Adjacent Tumor Free Tissue
... called histone lysine or arginine methyltransferases [10, 14], lysine may be mono-, di-, or tri-methylated, and arginine residues may be symmetrically or asymmetrically methylated ...a SET domain ...
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Epigenetic modifications of histones in cancer
... and SET domain) [113] and the methyl-lysine recogni- tion further promotes methylation activity ...formation. Methylation of histone H3 lysine 9 written by SUV39H1 creates a binding ...
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Histone Lysine Methylation: A Potential New Treatment Target with Respect to BDNF Gene in Type 2 Diabetic Retinopathy
... Histone methylation was first illustrated in the year 1964 [59] ...and methylation marks don’t alter the charge of proteins however function tying up docking sites for specific binding proteins ...
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Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells
... targeted histone methylation system with TAL effector repeat domains, we focused on E-cadherin regulation by the G9a-Snail ...methylate histone H3K9, we designed a TAL effector domain ...
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Tackling malignant melanoma epigenetically: histone lysine methylation
... EZH2. Unlike monomethylated H3K27, which is associated with gene activation, di-/trimethylated H3K27 act as re- pressive marks [75, 92]. Histone lysine methyltransferase EZH2 is mostly responsible for ...
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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
... above, histone 3 lysine 9 (H3K9) methylation is more controversially associated with the inactive X, based on a series of immunofluorescence ...di- methylation (H3K9me2) was ostensibly found on the ...
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Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions
... multiple histone K-methylation sites are known, advances in mass spectrometry have increased the num- ber of known sites ...we set out to use a high-throughput proteomics approach utilizing custom- ...
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Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation
... We thank the following colleagues at the University of Southern California: Dr. Peter A. Jones and Dr. Wange Lu for discussion and support; Dr. Colin Exline, Dr. Peilin Zhang, Dr. Sewoon Kim and Dr. Jueng Soo You for ...
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Conservation and function of the histone methyltransferase Set2
... containing SET domains in mammals (Rea et ...seven SET domain-containing genes (Schultz et ...only methylation at H3K4, H3K36, and H3K79 are found in yeast (Perrod and Gasser, ...
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Epigenetic regulation of flowering in Arabidopsis thaliana
... List of Figures Following Figure page 1.1 DNA methylation and histone methylation may interact in a self-perpetuating cycle to stabilise epigenetic states 12 1.2 Floral promotion pathway[r] ...
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Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
... DNA methylation inhibitor and a HDAC inhibitor for gene re-expression [35] led us to explore the effect of hydralazine plus valp- roic acid on global gene ...DNA methylation inhibitor 5-aza-2'-deoxycytidine ...
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Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis
... DNA methylation and histone methylation research have received significant progress in rheumatoid arthritis, the current researches generally have several ...differential methylation and ...
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Epigenetic regulation of caloric restriction in aging
... cases, histone remodeling occurs at the N-terminal group of lysine (K) residues in histones by diverse modification patterns such as acetylation, methylation, ubiquitination and ADP ribosylation, among ...
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Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix
... tides. Methylation in the cytokine residues of CpG dinu- cleotides present in these regions plays a key role in the regulation of p73 gene expression due to epigenetic ...
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Vojnic, Erika (2006): NMR solution structure of the Set2 SRI domain and preparation of RNA polymerase II complexes with the elongation factor Spt4-Spt5. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the histone lysine methyltransferase Set2 which has a modular ...the SET [Su(var)3-9, Enhancer of Zeste, Trithorax] ...Rpb1-interacting) domain of Set2 binds to the phosphorylated CTD ...
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Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae
... of histone acetylation (Xue-Franzén et ...of histone acetylation that is independent of HAT ...predict histone tails to be tightly intertwined with nucleosomal DNA (Li and Kono 2016; Shaytan et ...of ...
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Mechanisms of transcriptional repression by histone lysine methylation
... Jmjd2c cooperatively bind to agonist activated AR and catalyze the reversal of H3K9me3-imposed repression at several AR target genes (Wissmann et al., 2007). Moreover, simultaneous phosphorylation of H3T11 by the Prk1 ...
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Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition
... the methylation levels of approximately 300,000 CCGG sites, which is approximately 13% of all CCGG sites and ...the methylation status of other CG sites and non-CG sites were not ...the methylation ...
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