SH-SY5Y neuroblastoma cells
Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells
... Generally, the disturbance of the equilibrium between pro-oxidant and antioxidant homeostasis leads to oxida- tive stress that can further produce ROS in neuronal cells (Lepoivre, Flaman, Bobé, Lemaire, & ...
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In vitro neuroprotective potential of four medicinal plants against rotenone induced toxicity in SH SY5Y neuroblastoma cells
... exposure, cells were lysed with 25 μL of a cold lysis buffer [10 mM 4-(2- hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 2 mM ethylenediaminetetraacetic acid (EDTA), 5 mM3- [ (3 - cholamidopropyl ) ...
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Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide induced oxidative stress in human SH SY5Y neuroblastoma cells: role of anti apoptotic, pro survival and antioxidant genes
... on cells depends largely on the enormity of the insult and the ability of the cells to contain the insults or remove accumulating ...brain cells are normally sensitive to the effects of ROS because ...
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... of cells in S and G2/M ...on SH- SY5Y neuroblastoma cells and to explore the potential mechanism for alteration of tubulin-microtubule equilibrium causing mitotic arrest and NPY ...of ...
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... human SH- SY5Y neuroblastoma cells, but the effect was not ...that cells responded to FB 1 -increased ROS production by increasing glutathione synthesis to protect themselves from ...
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Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells
... control SH-SY5Y neuroblastoma cells and cells treated for 4 h with 1 μM hBCM7, bBCM7 or morphine were used, the latter serv- ing as a positive opioid effect ...
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TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
... progenitor cells [37], we hypothesized that TRPM7 may contribute to neuroblastoma metastasis by preserving progenitor- like, migratory neural crest cell ...neuroblastic SH-SY5Y TRPM7 shRNA ...
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PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment
... Tumor cells interact with the cells of the microenvironment not only by cell-cell-contacts but also by the release of signal ...carcinoma cells on SH-SY5Y neuroblastoma ...
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
... transfection, SH-SY5Y cells were cultured in standard culture medium in six-well plates and transfected with the pTRPM2-IRES-GFP construct using Xfect transfection reagent (Clonetech, Beijing, China) ...
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Edible bird’s nest ameliorates oxidative stress induced apoptosis in SH SY5Y human neuroblastoma cells
... circumstances, cells are likely to either slowly sequestrated and then degraded by autolysomes through autophagy, or undergo necrosis upon activation of death domain re- ceptors on cell ...in SH-SY5Y ...
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Direct observation of α-synuclein amyloid aggregates in endocytic vesicles of neuroblastoma cells
... Aggregation of α -synuclein has been linked to both familial and sporadic Parkinson ’ s dis- ease. Recent studies suggest that α -synuclein aggregates may spread from cell to cell and raise questions about the ...
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Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma
... human neuroblastoma (SH-SY5Y) and immortalized kidney cells (IHKE) revealed that total promoter methylation by CpG methyltransferase Sss I resulted in complete abrogation of transcriptional ...
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Neuroprotective effects of melittin on hydrogen peroxide induced apoptotic cell death in neuroblastoma SH SY5Y cells
... Oxidative stress induces neuronal cell death, which is implicated in many neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis [1-3]. The ...
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Coffee Modulates the Function of Brain Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH SY5Y Cells
... Effects of Coffee on BDNF-Mediated TrkB Phosphorylation in SH-SY5Y Cells To examine whether coffee affects the BDNF/TrkB signaling pathway, we measured the effects of coffee on the autop[r] ...
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BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells
... BACE inhibitor potency was shifted to the right (from 7 nM to 23 nM) in the presence of 3 nM LY450139, the concentration that normally increases Ab secretion. The concentration-dependent inhibition suggests that ongoing ...
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XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway
... An exciting study published recently in Nature [14], to- gether with an earlier one [15], has verified a new class of small molecule inhibitors, XAV939, which could block Wnt signaling in colon cancer cell lines by ...
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Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide induced cytotoxicity in human neuroblastoma SH SY5Y cells
... factor (BDNF)-mediated memory. Manufactured red LP in- creased NGF secretion and ERK phosphorylation in the B35 neuronal cell line and in PC12 cells [26]. Previous stud- ies demonstrated that LP contains several ...
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Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury
... the SH-SY5Y cells in co-culture and to visualize the morphology of the cells; immunostaining for activated caspase-3 was used to detect apoptosis in pneumolysin-treated G93A SOD1 cells: ...
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Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
... the SH-SY5Y cells were differentiated to become non-dividing cells with a neuronal phenotype, they are still derived from a neuroblastoma tumor lineage and are not primary ...
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Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity
... PC12 cells at low nanomolar concentrations [61], and in cultured rat cortical neurons and the human neuroblastoma cell line MSN, okadaic acid induced changes in neuronal cytoskeleton that led to cell death ...
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