• No results found

signal pathway

Original Article Molecular mechanism of ERK signal pathway in cell autophagy

Original Article Molecular mechanism of ERK signal pathway in cell autophagy

... ERK signal pathway in gastric cancer occurrence and potential values in ...ERK signal pathway activation. ERK signal pathway agonist PMA and inhibitor U0126 were used to ...

7

Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway

<p>Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway</p>

... 28 – 31 Since HDAC6-selective inhibitors showed a suppressive effect on colon cancer cells via the MARP/ERK signal pathway, and since the MAPK/ERK pathway plays an important role in colo[r] ...

11

The relationship between intervention in the CD40 signal pathway and choroidal neovascularization

The relationship between intervention in the CD40 signal pathway and choroidal neovascularization

... The pathogenesis of CNV is a complex process involving a variety of signal-mediated pathways. A variety of cytokines participate in the occurrence and development of CNV. The occurrence of CNV involves the rupture ...

5

The role of Hippo signal pathway in breast cancer metastasis

The role of Hippo signal pathway in breast cancer metastasis

... advancements in the field of oncology have led to the discovery of several complex and functionally diverse signaling pathways implicated in breast cancer metastasis. A common feature shared by these novel pathways are ...

9

TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

... (AKT) pathway, another downstream target of Wnt sign- aling pathway, has been put in a well-established role in providing proliferative signal and participating in ener- getic metabolism [17, ...

9

Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice

Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice

... the signal pathway of the OIR and OIR-control groups were significantly higher than those of the control group; however, in the cyclopamine group, these factors were reduced when compared with the OIR and ...

10

Therapies targeting the signal pathways of pheochromocytoma and paraganglioma

<p>Therapies targeting the signal pathways of pheochromocytoma and paraganglioma</p>

... PCC/PGL are discovered at 30 – 50 years old, and the incidence rate of males and females is basically equal. It has been reported that PCC/PGL have the highest heritability in human tumors. 8 Furthermore, it is a kind of ...

15

Original Article The role and mechanism of allyl isothiocyanate on suppressing tumor cells proliferation and invasion of human hepatocellular cancer HepG2 cell line

Original Article The role and mechanism of allyl isothiocyanate on suppressing tumor cells proliferation and invasion of human hepatocellular cancer HepG2 cell line

... apoptotic pathway and sig- nificantly up-regulated the downstream cas- pase-3 and caspase-8 activity, suggesting that Figure ...tumor-related signal pathway of HepG2 cell ...

7

JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells

<p>JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells</p>

... JuBei oral liquid (JB) is a traditional Chinese medicine, which is widely used in clinical practice for the treatment of chronic obstructive pulmonary disease and pneumonia. Seven medicinal herbs, Platycodon ...

14

Model simplification of signal transduction pathway networks via a hybrid inference strategy

Model simplification of signal transduction pathway networks via a hybrid inference strategy

... for signal pathway ...signalling pathway model as an example, simulation analysis demonstrates that the simplified model quantitatively predicts the dynamic behaviours of the ...

6

Possible hypoglycemic action of SX-fraction targeting insulin signal transduction pathway

Possible hypoglycemic action of SX-fraction targeting insulin signal transduction pathway

... indeed a complex biochemical process and more studies are required for further elaboration. Nevertheless, insulin resis- tance (of the IR) developed by the undefined (acquired and inherited) causes would block the ...

7

Cirsimaritin inhibits influenza A virus replication by downregulating the NF κB signal transduction pathway

Cirsimaritin inhibits influenza A virus replication by downregulating the NF κB signal transduction pathway

... Results: CST reduced viral titers and influenza A virus (IAV) RNA and protein synthesis in a dose-dependent manner. Mechanistically, CST had no inhibitory effect on the attachment and release processes of the viral life ...

9

T cell immune abnormalities in immune thrombocytopenia

T cell immune abnormalities in immune thrombocytopenia

... Co-stimulatory signal blockage triggers T cells to produce specific immune tolerance to ...CD28/B7 pathway is involved in T cell activation ...co-stimulatory signal pathway and induce T cell ...

6

Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway

Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway

... downstream signal pathway MAPK, the results demonstrated the Linc00976 significantly acti- vated the MAPK pathway, with the phosphorylated ERK, MEK, P38, JUK, and target gene Cyclin D1, CDK2, MMP2, ...

15

Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach

Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach

... cell signal transduction ...cell signal pathway could be divided into five types including Notch signaling pathway, Wnt signaling pathway, NF- kappa B signaling path- way, Hedgehog ...

8

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy

... The activity of the Rho family of small GTPase appears in part to be regulated by ras proteins (16–18). Included in this family of proteins are the 21kd protein rhoA, cdc42, and rac1. Studies in other cell types, ...

10

Ethylene signaling modulates contents of catechin and ability of antioxidant in Camellia sinensis

Ethylene signaling modulates contents of catechin and ability of antioxidant in Camellia sinensis

... Background: Tea is one of the most popular beverages in the world. There are many secondary metabolites can be found in tea such as anthocyanins, proanthocyanidins, flavonols and catechins. These secondary metabolites in ...

8

Integration of Transcriptional and Posttranslational Regulation in a Glucose Signal Transduction Pathway in Saccharomyces cerevisiae

Integration of Transcriptional and Posttranslational Regulation in a Glucose Signal Transduction Pathway in Saccharomyces cerevisiae

... induction pathway and the Snf1-Mig1 glucose repression ...a signal in the presence of glucose that inhibits the functions of Std1 and Mth1, paralogous proteins that regulate the function of the Rgt1 ...

7

Secretory protein traffic  Chromogranin A contains a dominant targeting signal for the regulated pathway

Secretory protein traffic Chromogranin A contains a dominant targeting signal for the regulated pathway

... secretagogue-stimulated release. These data demonstrate that human CgA expressed in PC-12 cells is targeted to regulated secretory vesicles. In addition, human CgA can divert an ordinarily non-secreted protein into the ...

14

Mechanisms of Notch signaling: a simple logic deployed in time and space

Mechanisms of Notch signaling: a simple logic deployed in time and space

... respond differently to Notch dynamics in cultured cells that have been engineered to conditionally express a constitutively active form of Notch (Nandagopal et al., 2018). Specifically, a short pulse of Notch activation ...

11

Show all 10000 documents...

Related subjects