Signal Transduction Pathway
Integration of Transcriptional and Posttranslational Regulation in a Glucose Signal Transduction Pathway in Saccharomyces cerevisiae
... Glucose also regulates the levels of Mth1 and Std1 in cells by regulating MTH1 and STD1 transcription via feedback and feedforward regulatory mechanisms that operate through two different glucose signal ...
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Possible hypoglycemic action of SX-fraction targeting insulin signal transduction pathway
... seven diabetic patients demonstrated over 30% (30%–63%) decline in their fasting blood Glc (FBG) levels under a SXF regimen of 2–4 weeks (Table 1). None of the participants presented palpable ailments or adverse effects ...
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Utilization of the Mating Scaffold Protein in the Evolution of a New Signal Transduction Pathway for Biofilm Development
... the signal transduction pathway was derived intact from the con- served ancestral mating pathway (2, ...conserved pathway for mating was borrowed intact for a very different phe- ...
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Wnt signal transduction pathway and apoptosis: a review
... Very interesting and novel are the data on the tumor suppressor protein, adenomatous polyposis coli (APC), and its role in apoptosis [14,17,18]. The gene encodes a large multidomain 2843 amino acid protein that is ...
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Regulation of Hepatitis B Virus Replication by the Phosphatidylinositol 3-Kinase-Akt Signal Transduction Pathway
... signaling pathway is one of the major oncogenic pathways and is activated in many types of human cancers, including hepatocellular ...this pathway on the replication of hepatitis B virus ...this ...
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Cirsimaritin inhibits influenza A virus replication by downregulating the NF κB signal transduction pathway
... In China, traditional Chinese medicine has been used for the treatment of influenza virus infection for many years [13, 14]. Artemisia scoparia Waldst and Kit is widely distributed in Xinjiang, China and com- monly used ...
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Kinetic analysis of a signal transduction pathway by time resolved somatic complementation of mutants
... branched signal- transduction pathway that integrates blue light, far-red light, heat shock and the starvation ...the pathway were isolated and three phenotypes obtained: blue-blind, ...
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Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
... signaling pathway consists of the ligand, Hedgehog (Hh); membrane protein receptor, Patched (Ptc); Smoothened (Smo); glioblastoma transcription factor, Gli; and downstream target ...signaling pathway is ...
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Model simplification of signal transduction pathway networks via a hybrid inference strategy
... NF-κB signal pathway, can be de- scribed by 24 state variables (components with distinct nuclear and cytoplasmic localizations) and 64 reactions (Ihekwaba et ...
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A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system
... Oscillation phenomenon is very common in biological systems. It is crucial to study oscillatory behaviors to understand gene regulation functions. Model-based analysis in combination with experimental study provides a ...
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Further Characterization of the Signaling Proteolysis Step in the Aspergillus nidulans pH Signal Transduction Pathway
... Alanine scanning mutagenesis of the PacC signaling pro- tease box. Having confirmed the suitability of PalB as the signaling protease, we turned to the further characterization of the substrate PacC, where we had ...
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A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy
... The activity of the Rho family of small GTPase appears in part to be regulated by ras proteins (16–18). Included in this family of proteins are the 21kd protein rhoA, cdc42, and rac1. Studies in other cell types, ...
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Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone
... Cells mutant for compo- nents of the mitogen-activated protein ( M A P ) kinase cascade (ste5, ste20, stell, ste7or fm? kssl) formed diploids at a frequency 1% that [r] ...
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West Nile Virus Inhibits the Signal Transduction Pathway of Alpha Interferon
... While this study was in progress, Mun ˜oz-Jorda ´n et al. (29) reported that the Dengue virus replication could inhibit the phosphorylation of STAT1 and, hence, explain the previously observed inhibition of the IFN ...
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Substitution of ras for the Herpesvirus Saimiri STP Oncogene in Lymphocyte Transformation
... ras signal transduction pathway in HVSDSTP/v-ras-transformed cells contributes to activation of the STP promoter by positive feedback, which may ultimately lead to the high level of v-ras gene ...
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Review: Novel Target for Cancer Therapy
... cell signal transduction pathway, mediating a number of cell physiological function and pathological changes, including the cells differentiation, proliferation, migration and invasion and metastasis ...
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Human CPR (Cell Cycle Progression Restoration) Genes Impart a Far– Phenotype on Yeast Cells
... There- fore, expression of the human CPR genes in yeast im- parts a dominant Far- phenotype, unlinking cell cycle arrest from the signal transduction pathway.. In mam- [r] ...
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Bleb driven chemotaxis of Dictyostelium cells
... cyclic-AMP signal transduction pathway were collected from the Dictyostelium community, and the fre- quency of bleb formation assessed in three different conditions: random migration under buffer to ...
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Identification and Characterization of FAR3, a Gene Required for Pheromone-Mediated G1 Arrest in Saccharomyces cerevisiae
... Analysis of FAR3 gene expression: Some yeast genes that are involved in the signal transduction pathway o r cell cycle control exhibit transcriptional regulation that is s[r] ...
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T cell immune abnormalities in immune thrombocytopenia
... Co-stimulatory signal blockage triggers T cells to produce specific immune tolerance to ...CD28/B7 pathway is involved in T cell activation ...co-stimulatory signal pathway and induce T cell ...
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