simian-human immunodeficiency virus
Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120
... chimeric simian/human immunodeficiency virus (SHIV) has provided a model system not only for evaluation of vaccines and antiviral therapies (6) but for studies of HIV infection and persistence ...
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Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4+ T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer
... 30). Simian/human immunodeficiency virus (SHIV)- infected rhesus monkeys have proven particularly useful for these studies, since they allow the in vivo evaluation in higher primates of immune ...
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Variability of Viral Load in Plasma of Rhesus Monkeys Inoculated with Simian Immunodeficiency Virus or Simian-Human Immunodeficiency Virus: Implications for Using Nonhuman Primate AIDS Models To Test Vaccines and Therapeutics
... with simian-human immunodeficiency virus ...or simian immunodeficiency virus mac 251 (SIVmac 251), we estimated variability in three viral load (VL) measures: peak VL, the ...
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Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques
... The GB40 MAbs recovered from dual staining of gp120 W479A ⫹ D368R ⫹ B cells showed only tier 1 (GB40_b1 to GB40_b9) or no (GB40_b10 to GB40_b13) neutralizing activity, indicating that this dual staining with gp120s was ...
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Simian-Human Immunodeficiency Virus Containing a Human Immunodeficiency Virus Type 1 Subtype-E Envelope Gene: Persistent Infection, CD4+ T-Cell Depletion, and Mucosal Membrane Transmission in Macaques
... of simian type D retroviruses, SIV, and simian T-lymphotropic ...(1). Human PBMC were isolated from a healthy blood donor stimulated with ...a human hybrid T-cell–B-cell line (provided by ...a ...
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A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.
... each virus passage, 10 ml of heparinized whole blood was obtained from the donor animal and inoculated intravenously into a naive ...recipient. Virus was reisolated from the PBL of monkey 345-91 7 days ...
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
... of virus load will almost certainly be a critical param- eter in the assessment of vaccine efficacy ...that virus load shortly after inoculation may be pre- dictive for vaccine ...on virus load as a ...
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Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
... to human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) virions with protein A-conjugated gold (PAG) nanoparticles using negative-stain electron ...
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Natural Infection of a Household Pet Red-Capped Mangabey (Cercocebus torquatus torquatus) with a New Simian Immunodeficiency Virus
... for simian immunodeficiency virus (SIV) antibody in household pet monkeys in ...using human immu- nodeficiency virus type 2 (HIV-2)/SIVsm, SIVmnd, and SIVagm antigens, one red-capped ...
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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
... transmitted human immunodeficiency virus type 1: virion-binding im- munoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial ...
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Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus
... of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) gp120 exterior enve- lope glycoprotein to the initial receptor, CD4 (1, 2), triggers con- ...
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Differences in the role of the cytoplasmic domain of human parainfluenza virus fusion proteins.
... of human immunodefi- ciency virus type 2 and simian immunodeficiency virus, it has been reported that truncation mutants significantly enhance cell fusion activity (27, 34) and alter ...
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Fundamental Difference in the Content of High-Mannose Carbohydrate in the HIV-1 and HIV-2 Lineages
... The virus-encoded envelope proteins of human immunodeficiency virus (HIV) and simian immunode- ficiency virus (SIV) typically contain 26 to 30 sites for N-linked carbohydrate ...
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Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance
... of simian-human immunodeficiency virus (SHIV)- and SIV-infected RMs also found that ZIKV viremia was uncharacteristically low during coinfection; however, the authors concluded that SHIV/SIV ...
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Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein
... a virus-specific immune ...HIV-2, simian immunodeficiency virus from tan- talus monkeys (SIVtan), feline immunodeficiency virus (FIV), and Ebola virus; the Nef protein of ...
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Brain Macrophages in Simian Immunodeficiency Virus Infected, Antiretroviral Suppressed Macaques: a Functional Latent Reservoir
... A human immunodeficiency virus (HIV) infection cure requires an un- derstanding of the cellular and anatomical sites harboring virus that contribute to vi- ral rebound upon treatment ...a ...
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Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication
... pathogenic simian immunodeficiency virus (SIV) mac239 clone has been well charac- ...from human immunodeficiency virus type 2 (HIV-2)-infected ...of human CD4, CD28, CD3, ...
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Genetic analysis of simian virus 40 from brains and kidneys of macaque monkeys.
... Thus, SV40 appears to be an opportunistic pathogen in the setting of simian immunodeficiency virus-induced immunodeficiency, similarly to JC virus in human immunodeficiency virus-infecte[r] ...
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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... chimeric virus derived from vi- ruses found in monkey species known to be preyed upon by chimpanzees (1, ...recombinant virus is that at least one chimpanzee became infected with one of these two viruses ...
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Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections
... Human subjects, sample collection, and clinical parameters.Periph- eral blood samples and small intestinal biopsy specimens were obtained from HIV-infected antiretroviral therapy-naive individuals (n ⫽ 5) and from ...
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