Skin fibrosis
The role of fibrin in skin fibrosis
... in skin depth and fascial layer ...deficient skin, and was observed primarily in the ...of skin fibrosis, characterised by excessive accumulation of collagen and disruption of skin ...
244
Adipocyte specific Repression of PPAR gamma by NCoR Contributes to Scleroderma Skin Fibrosis
... on skin fibrosis and its expression in patients with ...dermal fibrosis in mice. Moreover, skin fibrosis in SSc is accompanied by increased NCoR activity and de- creased expression of ...
11
pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis
... in fibrosis (16), imatinib may target multiple profibrotic pathways in ...of fibrosis following imatinib treatment in patients with graft-versus-host disease and nephrogenic systemic ...Rodnan skin ...
18
Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis
... fibrotic skin over 14 days altered additional facets of skin ...select fibrosis- and adipose-associated transcripts (5, 24, 32–41) (Figure 4H), and DC depletion exacerbated some changes while ...
16
Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
... of skin fibrosis remains ...in skin fibrosis, we subjected wild-type and PAR-1-deficient mice to a model of bleomycin-induced skin ...of skin fibrosis and we suggest that ...
7
CD19 dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight skin mouse
... cutaneous fibrosis and autoantibodies against SSc-specific target ...of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknown, we recently demonstrated that SSc patients overexpress CD19, ...
11
Wenyang Huazhuo Tongluo formula, a Chinese herbal decoction, improves skin fibrosis by promoting apoptosis and inhibiting proliferation through down regulation of survivin and cyclin D1 in systemic sclerosis
... Considering the unsatisfactory effect of current ther- apies for SSc, it would be desirable to have novel drugs/ therapies. Traditional Chinese medicine (TCM) has a long history of dealing with diseases and evolved over ...
9
Combined effect of genetic background and gender in a mouse model of bleomycin induced skin fibrosis
... dermal fibrosis is widely used to study the changes that take place in the early phase of the disease ...local skin fibrosis, which is known to persist for up to six weeks ...lung fibrosis [7] ...
12
Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis
... heart fibrosis through inflammation and upregulation of matrix deposi- tion ...of skin fibrosis in ...healthy skin, the Ang II precursor angiotensinogen is expressed in SSc skin ...
12
Measurement of matrix metalloproteinase 9-mediated Collagen type III degradation fragment as a marker of skin fibrosis
... of skin fibrosis have been developed including models utilising exogenous applica- tion of growth factors [10] and the chromosome 2 dominant mutation of tight skin (Tsk) ...Bleomycin-induced ...
7
B cell depletion therapy upregulates Dkk 1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis
... the skin in scleroderma. Dkk-1 is virtually undetectable in the skin of patients with SSc in sharp contrast to healthy skin where it is clearly ...→ fibrosis) and have highlighted the role of ...
9
PAI1 mediates fibroblast–mast cell interactions in skin fibrosis
... PAI1-mediated heterotypic adhesion leads to activation of both fibroblasts and mast cells. The role of PAI1 as an inducer of mast cell adhesion to fibroblasts led us to probe the effect of this het- erotypic interaction ...
14
Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene
... From these results several conclusions can be drawn. First, the pdFbn-1 gene contributes to the occurrence of cutaneous hyperplasia. Continuous high expression of the mutated gene in high copy number Tg mice causes a ...
12
mPGES 1 null mice are resistant to bleomycin induced skin fibrosis
... in skin of patients with SSc [36,37] and these cells are key producers of a variety of pro-fibrotic cytokines such as transforming growth fac- tor-beta (TGF-b), CC-chemokine ligand 2, and IL-4 and IL-17 ...
10
Recent advances in the treatment of skin involvement in systemic sclerosis
... extensive fibrosis of the skin and various internal ...tissue fibrosis, the studies on anti-fibrotic drugs against SSc provide us much useful information regarding the strategy for the treatment of ...
6
Protective effect of α-lipoic acid against radiation-induced fibrosis in mice
... radiation-induced skin fibrosis and inhibited HAT activity of p300 that occurs through increased TGF-β1 expression in NIH- 3T3 cells after ...normal skin and lung fibroblasts ...
12
Technical report on the Bottlenose dolphin (Tursiops aduncus) unusual mortality event within the Swan Canning Riverpark, June-October 2009
... There was discussion about whether this dolphin had suffered skin damage to predispose it to the fungal infection. There is a possibility that this dolphin might have swam through corrosive substances, low pH ...
44
CCL1 blockade alleviates human mesenchymal stem cell (hMSC)-induced pulmonary fibrosis in a murine sclerodermatous graft-versus-host disease (Scl-GVHD) model
... in skin tissue; dissimilarly, hMSCs resulted in a localization of Scl-GVHD in injured lungs, which worsened pulmonary ...on skin and lung tissues in an established Scl-GVHD model, which may offer up a ...
12
TGF β1 and PDGF AA override Collagen type I inhibition of proliferation in human liver connective tissue cells
... of fibrosis by modulating myofibroblast proliferation and collagen ...chronic fibrosis there is concomitant deposition of collagen, a known inhibitory factor, and sustained cell proliferation, raises the ...
9
Critical roles for IL 4, IL 5, and eosinophils in chronic skin allograft rejection
... into skin allografts (16, 48, 56, ...and fibrosis (1, 9, 58, ...interstitial fibrosis in anti–IL-5 mAb–treated and IL-5–deficient mice was a normal appearance of the allogeneic skins, which were ...
10