Smac mimetic
Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
... Should instead read: ‘Restoring the apoptotic cell death machinery by pharmacological inhibition of IAPs proteins represents a compelling strategy for cancer therapy. APG-1387 is a novel Smac mimetic ...
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Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
... The recent trials of birinapant and DEBIO1143 (AT-406) reported patients showed a trend towards increased circu- lating TNF-α [15, 36]. Inaddition, the inhibition of NF-κB could sensitize the resistant to Smac ...
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Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers
... malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the therapeutic ...
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Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma
... Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients. Here, we ...
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RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death
... death [12], in the present study we show that RSL3 but not Erastin induces ferroptosis when used at subcytotoxic doses in combination with the Smac mimetic BV6. This points to the existence of differences ...
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Original Article SMAC mimetic SM-164 enhanced adriamycin induced apoptosis and cell cycle arrest in osteosarcoma cell line HOS
... SM-164 is a novel bivalent SMAC mimetic. Compared with its monovalent form SM-162, SM-164 is 1,000 times more potent than SM-122 as an inducer of apoptosis in tumor cells [16]. In our study, treatment of ...
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The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
... using SMAC mimetics has been shown to sensitize pancreatic cancer cells to gem- citabine [11, ...the SMAC peptidomimetic, needs to be rendered cancer selective, since a non-selective mimetic would ...
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SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells
... Drug combination treatments are essential for more effective cancer therapies. Here, we describe a combination screen of the SMAC mimetic Debio 1143 with 128 other agents against a panel of lung ...
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Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic
... and others have shown that it is possible to achieve a cytotoxic effect with much lower concentrations of poly (I:C) (in the range of 1 μg/ml) provided that the TLR3 agonist is combined with a Smac-mimetic ...
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Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
... note, Smac mimetic has been shown to overcome apoptosis resistance in caspase 8-deficient cells by priming TNFα to induce caspase-independent necroptosis or sensitizing apoptosis-proficient cells to ...
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Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells
... used in clinical protocols for the treatment of NB. We used the NB cell line SH-EP, which was previously shown to represent a suitable in vitro model of NB and to express key apoptosis regulators such as caspase-8 [10, ...
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The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
... of SMAC and lead to degradation of IAP proteins, termed SMAC mimetics, are actively being investigated in both hematologic malignancies and solid tumors [2, ...studies, SMAC mimet- ics induce ...
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Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L
... Smac mimetics (SM) were able to induce apoptosis and to significantly increase efficacy of classic treatment in several experimental cancer models [10, 13]. In neuroblastoma cell lines we could demonstrate a ...
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Elucidating Ubiquitin Chain Formation Catalyzed by E2 Enzymes through use of a Di Ubiquitin Probe
... of Smac or applying Smac mimetic compounds could directly trigger cancer cell death or sensitized tumor cells to other cancer therapeutic agents (80, 81, 87, 89, ...of Smac upon infection by ...
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Mimetic desire and scapegoat mechanism in sport
... the mimetic conflict transforms into a general ...of mimetic interaction is resolved in the same way; the mechanism can also provide a solution – by one person, then another, and finally the whole group ...
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Mimetic desire in autism spectrum disorder
... Reciprocal influence is an essential aspect of social be- havior: individuals are influenced by others in their beliefs and preferences [1]. An essential element of this influence is mimetic desire (MD), which is ...
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Hypoxia mimetic agents for ischemic stroke
... Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional Chinese medicine with properties like heat-clearing and detoxification (Zhang Q. et al., 2014). In cerebral cortical neurons, pretreatment with HLJDT increased HIF-1α, EPO ...
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An Efficient Object Sensor Movement using SMAC Algorithm
... Michael, G., Chandrasekar, A.,”Modeling of detection of camouflaging worm using epidemic dynamic model and power spectral density”, Journal of Chemical and Pharmaceutical SciencesJCPS Vo[r] ...
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Type I Interferon Mimetics Bypass Vaccinia Virus Decoy Receptor Virulence Factor for Protection of Mice against Lethal Infection
... ␣ mimetic similarly possessed potent adjuvant effects against BSA, a weak ...mask mimetic adjuvancy, so the rationale behind the use of BSA as a test of adjuvancy was its weak immunoge- ...IFN-␣1 ...
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SMAC — A Modular Open Source Architecture for Medical Capsule Robots
... the SMAC platform starts to be adopted by research‐ ers, the user community will identify bugs and sources of error that the authors did not envisage at the time of writing, such as preventing a malicious attack ...
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