Smad signaling pathway
Involvement of the bone morphogenic protein/SMAD signaling pathway in the etiology of congenital anomalies of the kidney and urinary tract accompanied by cryptorchidism
... In the present study, non-synonymous SNPs in both BMP8B and SMAD4 loci were found to be common to all patients with CAKUT accompanied by cryptorchidism, sug- gesting that impairment of the BMP/SMAD ...
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Original Article Overexpression of the BMP4/SMAD signaling pathway in skull base chordomas is associated with poor prognosis
... (BMP4) signaling, which acts upstream of Brachyury in embryonic development, has been impli- cated in carcinogenesis in multiple ...BMP4/SMAD signaling path- way in the pathogenesis of chordoma, we ...
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Effect of curcumin on an animal model with hepatic fibrosis via tgf β/smad signaling pathway
... TGF-β/Smad signaling pathway. Many cytokines and signaling pathways are involved in the development of liver ...structure. Smad is a downstream signaling molecule of TGF-β, and ...
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Original Article Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis
... SP-1 is also involved in the regulation of type I collagen expression. SP-1 may be involved in the activation of HSC collagen I gene promoter regions FP1 and FP2. Over-expression of SP-1 enhances the promoter activity, ...
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Original Article Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-β1/Smad signaling pathway
... Abstract: Renal fibrosis is characterized by an exacerbated accumulation of deposition of the extracellular matrix (ECM). The eukaryotic translation initiation factor (eIF) 3a is the largest subunit of the eIF3 complex ...
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The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF β/Smad signaling pathway
... It is well-known that CyclinD1 is an important regula- tor of host cell cycle, and it could promote cells from G1 phase to S phase that would shorten the period of cell cycle and accelerate cell proliferation. ...
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<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... GTPase-activating protein SH3 domain-binding protein 1 (G3BP1), a RasGAP SH3 domain-binding protein belonging to the RNA-binding protein family, plays a crucial role in the regulation of Ras signaling. 4 G3BP1 is ...
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Original Article Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway
... Abstract: Objective: This research aimed to explore the protective effect of melatonin on diabetic nephropathy (DN) rats induced by streptozotocin (STZ) and its related signaling pathways. Methods: 100 SPF male ...
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<p>HOXD9 Activates the TGF-β/Smad Signaling Pathway to Promote Gastric Cancer</p>
... They investigated the HOXD9 function in glioma cell lines, and their results suggested that silencing HOXD9 could effectively suppress the proliferation of U87 glioma cells and promote c[r] ...
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Nodal regulates bladder cancer cell migration and invasion via the ALK/Smad signaling pathway
... RT4 and KMBC2 cells transfected with siNC and siNodal were washed three times with cold PBS and then lysed using RIPA buffer (Thermo Fisher Scientific, Waltham, MA, USA) containing phenylmethane sulfonyl fluoride. ...
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Hyperglycemia promotes Snail-induced epithelial–mesenchymal transition of gastric cancer via activating ENO1 expression
... There is no doubt that EMT plays a vital role in tumor invasion and metastasis. During EMT, epithelial cells lose their apical-basal polarity, reorganize the cytoskel- eton, show increased cell motility and gain ...
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<p>Involvement of TGF-β and ROS in G1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Under UVA Irradiation in a 3D Spheroid Model</p>
... irradiation triggered the initiation of the TGF- β /Smad signaling pathway, increasing the expression levels of TGF- β 1, Smad3, Cdkn1a, and Cdkn2b at both the mRNA and protein level, wh[r] ...
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Schisandrin B attenuates CCl<span style="font-size: 8.33333px">4</span>-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
... dant signaling and suppressing HSC activation by inhibiting the transforming growth factor-β (TGF- β )/Smad signaling ...of Smad and signaling of mitogen-activated protein ...
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Original Article TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis
... downstream signaling and the contribution of the recruited MSCs are still ...TGF-β1/Smad signaling pathway proteins, MMP-14, and MSC markers in the process of neointima formation using a rat ...
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<p>Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition</p>
... 1/Smad signaling pathway is involved in many diseases, including cardiovascular diseases, neurologi- cal disorders and ...1/Smad signaling pathway in ventricu- lar remodeling ...
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Original Article Triptolide inhibits lipopolysaccharide-induced proliferation, induces apoptosis and causes cell cycle arrest of human mesangial cells in vitro
... a Smad signal transduction pathway-dependent mech- anism, but the relationship between the TGF- β1/Smad signaling pathway and mesangial cell apoptosis has not been fully elucidated [29, ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... signal pathway could be divided into five types including Notch signaling pathway, Wnt signaling pathway, NF- kappa B signaling path- way, Hedgehog signaling ...
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BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
... (Cell Signaling Technology); type II collagen and Pth1r (Abcam); type I collagen (Southern Biotech); type X collagen (a kind gift from Robin Poole, Shriners Hospitals for Children, Montreal, Québec, Canada); ...
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Original Article TGF-β1 suppresses syndecan-2 expression through the ERK signaling pathway in nucleus pulposus cells
... Numerous studies have reported that TGF-β1 has multiple roles in the process of IVDD. Risbud MV et al. showed that TGF-β1 regulated galectin-3 expression through the canonical Smad3 signaling pathway in NP ...
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The dynamic roles of TGF β signalling in EBV associated cancers
... kinase pathway; Smad signalling alone was not sufficient to mediate TGF-β1 induction of Zta ...PI3K/AKT pathway, acting downstream of ERK 1/2, enabled Smad3 to be acetylated by direct interaction ...
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