Smooth muscle cell proliferation
Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
... that Th2 cytokines IL-4, IL-5 and IL-13 or TGF-β and IL-6 play a crucial role due to their possible role in air- way remodeling. The treatment of ASM with IL-1α and TNF-α attenuated the mitogenic effects of bFGF and ...
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Original Article miR-3646 promotes vascular inflammation and augments vascular smooth muscle cell proliferation and migration in progression of coronary artery disease by directly targeting RHOH
... In the present study, we found that miR-3646 was significantly upregulated in the serum sam- ples of CAD patients and AMI mice. A positive- correlation between miR-3646 and TNFα was observed in these samples. ...
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A role for focal adhesion kinase in vascular smooth muscle cell proliferation, migration and differentiation
... stimulated cell growth reducing the proliferative index by 77 +/- 12% after a 24 hour treatment as assessed colorimetrically by monitoring cleavage of the tetrazolium salt, WST- ...other cell types, we ...
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Inhibition of smooth muscle cell proliferation in injured rat arteries Interaction of heparin with basic fibroblast growth factor
... inhibits smooth muscle cell (SMC) proliferation after arterial injury by mechanisms that have yet to be ...SMC proliferation is mediated by basic fibroblast growth factor (bFGF), we ...
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Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A
... Airway smooth muscle (ASM) hyperplasia is a key feature of airway remodeling in development of lung diseases such as ...Anomalous proliferation of ASM cells directly contributes to ASM ...ASM ...
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Inhcer of β-Interferon
... address the role of ,3-IFN in limiting vascular smooth muscle cell proliferation after balloon injury in a porcine gene transfer model.. Expres-.[r] ...
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ICAM 1 Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF Induced Proliferation of Vascular Smooth Muscle Cells
... phosphorylation of Rb. Thus, T0901317 may play a protective role in preventing atherosclerotic plaque formation [17, 28]. ICAM-1, which is highly expressed fol- lowing PDGF-BB treatment, was chosen as the target of ...
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The extracellular signal regulated kinase (ERK) pathway: a potential therapeutic target in hypertension
... vascular smooth muscle contraction and could underlie the changes in vasoconstriction in ...vascular smooth muscle phenotype and increases in vascular smooth muscle cell ...
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Original Article MiR-21 facilitates the proliferation of smooth muscle cells and atherosclerotic plaque formation by suppressing PTEN to activate AKT
... examined. Smooth muscle cells treated with oxLDL were used to investigate the targeted regulation between PTEN and miR-21, along with miR-21’s effects on the AKT signal pathway and cell ...inhibited ...
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Protective Effect of Pyrogallol-phloroglucinol-6,6-bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction
... associated vascular smooth muscle cell proliferation and migration by decreasing the 25.. phosphorylations of ERK and AKT.[r] ...
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Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling
... Nrf2 plays a key role in VSMC cellular proliferation and neointima formation[14]. An investigation has determined that enhanced Nrf2 activity has an antiproliferative effect, thus contrib- uting to the induction ...
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The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
... HASMCs were planted onto 96-well plates (Corning, USA) at a density of 1 × 10 4 /well and incubated with various dose of ISL for 48 h. BrdU cell proliferation ELISA kit (Abcam, USA) was used. Briefly, cells ...
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Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis Alpha smooth muscle actin is a marker of mesangial cell proliferation
... Mesangial cell proliferation is common in glomerulonephritis but it is unclear if proliferation is associated with any in vivo alteration in ...alpha-smooth muscle actin in a mesangial ...
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Cyclosporine induced synthesis of endothelin by cultured human endothelial cells
... Endothelin (ET), a peptide synthesized by endothelial cells (EC), causes a decreased renal blood flow and glomerular filtration rate and an increased mean arterial pressure when infused in animals. In tissue culture, ET ...
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Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig
... Patients with chronic obstructive pulmonary disease (COPD) show intimal hyperplasia in pulmonary muscu- lar arteries, which results from the proliferation of smooth muscle cells (SMCs), and an ...
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Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
... aging, cell senescence and syn- thetic SMC phenotypes have been documented in AAA patients or those with risk factors for AAA ...SMC proliferation in a variety of ways depending on source and model, and ...
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Can the activation of plasminogen/plasmin system of the host by metabolic products of Dirofilaria immitis participate in heartworm disease endarteritis?
... stimulation cell proliferation was analyzed by crystal violet nuclei staining over 10 days to determine the number of viable cells, as previously described ...or smooth muscle cells previ- ...
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Original Article Cholesterol induces dedifferentiation of vascular smooth muscle cells by regulating monocyte chemotactic protein-1-induced protein 1
... of cell vitality, differ- entiation and apoptosis, MCPIP1 has been demonstrated to play a pivotal role in the occur- rence and progression of a wide array of vascu- lar diseases ...endothelial cell ...
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Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
... aging, cell senescence and syn- thetic SMC phenotypes have been documented in AAA patients or those with risk factors for AAA ...SMC proliferation in a variety of ways depending on source and model, and ...
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Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions
... vascular smooth muscle cell (vSMC) prolifera- tion in vascular disease, particularly atherosclerosis, is controversial and unresolved ...vSMC proliferation is clearly crit- ical and thus a ...
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