soluble RANKL
Soluble Rank Ligand Produced by Myeloma Cells Causes Generalised Bone Loss in Multiple Myeloma
... the RANKL/OPG pathway has been shown to underlie formation of focal osteolytic lesions, its role in the development of osteoporosis in myeloma remains ...Increased soluble RANKL in serum from ...
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Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
... between RANKL mRNA and serum RANKL observed in the men? Because we measured total serum RANKL, this cannot be accounted for by differential complexing of serum RANKL with OPG or other serum ...
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Changes in Bone Metabolism in Young Castrated Male Rats
... free soluble RANKL in the bone marrow of aged rats can stimulate bone metabolism,22 particularly increased bone turnover in association with increased serum ALP and osteocalcin levels,23[r] ...
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Anti-RANKL therapy for bone tumours: Basic, pre-clinical and clinical evidences
... [25]. RANKL transgenic mice and RANKL knockout mice are respectively osteoporotic and osteopetrotic ...and soluble RANKL produced by osteoblasts interact with RANK expressed on monocyte ...
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Changes in RANKL during the first two years after cART initiation in HIV infected cART naïve adults
... For RANKL, 100 μl of pre-prepared standards/controls and samples were added to the reaction wells of the microarray, and 100 μl biotinylated anti soluble RANKL antibody was then added to each ...
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Targeting RANKL in metastasis
... tumor RANKL levels, as single variables, with patient ...of RANKL expression in primary tumors or limitations in mRNA detection for RANKL using different mRNA detection ...of RANKL in breast ...
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Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study
... κB; RANKL: Receptor Activator of Nuclear factor κB Ligand; sRAGE: Soluble receptor of advanced glycation end‑products; sRANKL: Soluble RANKL; t‑ucMGP: Total‑ uncarboxylated Matrix Gla Protein; ...
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Serum levels of osteoprotegerin and receptor activator of nuclear factor -κB ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study
... of RANKL, a lower OPG/RANKL ratio, and comparable OPG levels compared to controls ...OPG/ RANKL ratio in oligoarticular and polyarticular JIA patients compared to controls, in contrast to the other ...
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Biology of RANK, RANKL, and osteoprotegerin
... However, RANKL does not induce OCP mobilization in protein tyrosine phosphatase- ε knockout mice with osteoclasts that are defective in terms of bone adhesion and resorption ...Thus, RANKL-induced ...
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Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model
... in RANKL/OPG, stimulate osteoclast activity, and lead to the dissolution of bone around ...of RANKL- induced osteoclast formation by berberine inhibited osteoclast formation and bone destruction in a ...
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Role of RANKL inhibition in osteoporosis
... precursors, RANKL controls the differentiation, proliferation, and survival of ...to RANKL have been demonstrated to occur with estrogen deficiency, hyperparathyroidism, and other disorders that stimulate ...
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RANK-RANKL signalling in cancers
... 114. Luo, J., Yang, Z., Ma, Y., Yue, Z., Lin, H., Qu, G., Huang, J., Dai, W., Li, C., Zheng, C., Xu, L., Chen, H., Wang, J., Li, D., Siwko, S., Penninger, J.M., Ning, G., Xiao, J. and Liu, M. (2016) LGR4 is a receptor ...
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Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow derived cells
... It is premature to draw any conclusion on development of a potential therapeutic agent for treatment of osteoporosis, but salubrinal possesses several unique features. First, it is a small synthetic chemical agent, which ...
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Celecoxib: considerations regarding its potential disease modifying properties in osteoarthritis
... ammation RANKL is also produced by T lymphocytes and fi broblast-like synovio ...a soluble decoy receptor for RANKL, can prevent the biological eff ects of RANKL, and the ratio between OPG and ...
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Signaling crosstalk between RANKL and interferons in osteoclast differentiation
... mechanism, RANKL also induces expression of c-Fos ...this RANKL signaling must be properly ...a soluble ‘decoy’ receptor for RANKL, is known as a nega- tive regulator of osteoclastogenesis ...
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Anti RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed type hypersensitivity arthritis (DTHA) model
... Background: The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor ...
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Evaluation of Serum RANKL and OPG Concentrations in Patients with Periodontitis in Saudi Arabia
... Periodontitis is characterized by the loss of connective tissue attachment and alveolar bone and has been the most common form of the inflammatory diseases in humans.[1]. Bone mass is determined by a careful balance ...
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Understanding how ESOL Pre Services Teachers' Prior Experiences and Background Shape their Processes of becoming L2 (Reading) Teachers
... paracrine RANKL-RANK signaling could be responsible for driving prostate cancer bone metastasis by promoting epithelial to mesenchymal transition ...converging RANKL-c-Met signaling network in which the ...
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Attenuated RANKL induced cytotoxicity by Portulaca oleracea ethanol extract enhances RANKL mediated osteoclastogenesis
... in RANKL-mediated ...that RANKL stimulation on bone marrow-derived macrophages (BMMs) transmit diverse signal pathways which mediate numerous and various cellular responses, such as cellular motility, ...
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Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
... with RANKL in the absence or presence of IL-1β and diacerein or rhein at 20 μg/mL (n = ...under RANKL treat- ment, which was associated with an increase in the rate of osteoclast formation under IL-1β ...
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