somatostatin receptor
Somatostatin receptor based PET/CT in patients with the suspicion of cardiac sarcoidosis: an initial comparison to cardiac MRI
... value for CS detection and patient prognostication [2, 8–10]. However, specificity of FDG-PET is hampered by physiologic tracer accumulation requiring dedicated patient preparation [11–13]. As a more specific ...
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Feasibility of a streamlined imaging protocol in technetium-99m-Tektrotyd somatostatin receptor SPECT/CT
... express somatostatin receptors, the presence of which, particularly subtypes 2 & 5, allows detection with radiolabelled peptide somatostatin analogues ...radionuclides, Somatostatin ...
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Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201 995 in treatment of human endocrine tumors
... of somatostatin receptors has been demonstrated in various endocrine tumors as well as in normal ...human somatostatin receptor subtypes ...the somatostatin receptor subtypes expressed ...
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Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions
... particularly somatostatin receptor type 2 (SSTR2), are expressed at very low levels in most organs and tumors, except in differentiated neuroendocrine carcinoma (NECA) ...this receptor a favorable ...
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Somatostatin receptor PET/CT in restaging of typical and atypical lung carcinoids
... differential somatostatin receptor expression, partially depending on tumor ...both somatostatin receptor-positive and receptor-negative lesions as compared to TC patients which had ...
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Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours
... Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours ORIGINAL ARTICLE Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours BJJ Abdullah, FRCR*, M Para[.] ...
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The NETPET Score: Combining FDG and Somatostatin Receptor Imaging for Optimal Management of Patients with Metastatic Well-Differentiated Neuroendocrine Tumors
... purely somatostatin receptor-positive lesions without FDG uptake above background and P5 the presence of significant FDG-positive/somatostatin receptor-negative ...
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Somatostatin receptor 2A protein expression characterizes anaplastic oligodendrogliomas with favorable outcome
... Diffuse gliomas are classified according to the 2016 WHO Classification of Tumors of the Central Nervous System, which now defines entities by both histology and molecular features. Somatostatin receptor ...
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Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells
... the somatostatin receptor sst2 as a negative growth ...the receptor which re- sulted from the induction of sst2 ligand and led to the genera- tion of a negative autocrine growth-regulatory ...
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Original Article Somatostatin receptor immunohistochemistry in neuroendocrine tumors: comparison between manual and automated evaluation
... Abstract: Background: Manual evaluation of somatostatin receptor (SSTR) immunohistochemistry (IHC) is a time- consuming and cost-intensive procedure. Aim of the study was to compare manual evaluation of ...
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Original Article Correlation of monoclonal and polyclonal somatostatin receptor 5 antibodies in pancreatic neuroendocrine tumors
... of somatostatin-receptor 5 (SSTR 5) in pancreatic neuroendocrine tu- mors by using monoclonal and polyclonal ...pansomatostatin receptor analogues will rise the adverse effects connected to SSTR5 ...
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The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist
... octreotide-based somatostatin receptor-target ing peptides, and the [HYNIC, Tyr 3 ]octreotide/edda kit (HYNIC-TOC) is registered in some European ...
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Somatostatin receptor based hybrid imaging in sarcoidosis
... The somatostatin receptor subtype 2 (SSTR2) is highly expressed in sarcoid ...SSTR2 receptor expression is beneficial for somatostatin receptor scintigraphy (SRS) using 111 ...
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Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy
... express somatostatin receptors (SSTRs) has proven effective for the treatment of advanced, low- to intermediate-grade neuroendocrine tumors in the ...usage, somatostatin peptide-based analogs, labeled with ...
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Membrane-displayed somatostatin activates somatostatin receptor subtype-2 heterologously produced in Saccharomyces cerevisiae
... We applied our technology for displaying peptide ligands on a plasma membrane to human SSTR2 that was het- erologously produced in yeast cells. Functional activation of the pheromone response pathway by the membrane- ...
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A unique control mechanism in the regulation of insulin secretion Secretagogue induced somatostatin receptor recruitment
... In this study, we have correlated the translocation of somatostatin (SRIF) receptors from the cell interior to the plasma membrane with the ability of SRIF to inhibit insulin release. Islets were perifused with ...
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Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function
... Somatostatin directly inhibits exocytosis via inhibition of cAMP accumulation and calcium fluxes, thereby inhibiting hormone secretion (54). We now extend this understanding of somatostatin func- tion by ...
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Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues
... hormone somatostatin (SST) exerts antiproliferative, antiangiogenetic, proapoptotic, anti-nociceptive and other effects through binding to its receptors, such as ...
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Somatostatin receptor expression in small cell lung cancer as a prognostic marker and a target for peptide receptor radionuclide therapy
... of individualized PRRT with safe administration of higher activities (data not published), possibly resulting in improved outcomes. This study has various limitations. It is retrospective and comprises a very limited ...
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Expression of somatostatin receptor subtypes in human thyroid tumors: the immunohistochemical and molecular biology (RT-PCR) investigation
... cases. Multiple SSTR subtypes were found to coexist in each case of investigated tissue (Table 2). Most of the specimens showed mixed distribution pattern of the receptors – cyto- plasmic and membranous. Strong and ...
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