Sonic hedgehog, cell signaling
FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
... through cell-cell signaling mechanisms involving locally secreted signaling molecules (Jessell, ...ligand sonic hedgehog (SHH), which is produced by cells at the ventral midline ...
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<p>Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression</p>
... The brains of deeply anesthetized rats were promptly removed on day 31 after EA treatment. Ischemic hippocampi were isolated and frozen in liquid nitrogen. Total protein measurement for Shh, Gli1, Ptch1, and Smo in ...
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Characterization of the arterial adventitia as a Sonic Hedgehog responsive niche
... either cell type alone 75, 76 ...paracrine signaling relationship between different adventitial cell types and provide further support for the importance of the adventitia as a mediator of ...
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Original Article Activation of sonic hedgehog signaling attenuates oxidized low-density lipoprotein-stimulated brain microvascular endothelial cells dysfunction in vitro
... and cell apoptosis [9, 20, ...thelial cell apoptosis, indicating that SHH was involved in the oxLDL-induced cytotoxicity for- mation in ...oxLDL-induced cell apoptosis through the overexpression of ...
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PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway
... medium (SMGM). The following day, the cells were washed and transferred to 0.2% FBS-containing DMEM- F12 for 24 h, and subsequently treated with TAPM2.5 (15 μg/ml) or WSPM2.5 (3 μg/ml) for an additional 48 h. At the end ...
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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
... Shh signaling mutants (Machold et ...SVZ cell proliferation and in the number of cells with stem cell properties and resulting neurons, while blocking its function decreases their ...EGF ...
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Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
... of Hedgehog signaling and a putative ciliary motor ...in cell lines caused defects in cilia formation and induced abnormal centrosomal duplication and fragmentation of the Golgi ...
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Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification
... and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is ...and ...
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The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
... granule cell precursors (GCPs). We have previously shown that sonic hedgehog (Shh) signaling correlates spatially and temporally with fissure formation, and that Gli2 is the main activator ...
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Vila, Greisa (2004): Sonic hedgehog signaling pathway in normal and adenomatous pituitary. Dissertation, LMU München: Medizinische Fakultät
... The pathogenesis of pituitary adenomas is very complex. Studies examining X- chromosome inactivation in female patients have shown that pituitary adenomas are monoclonal. This is also supported by the lack of associated ...
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Biochemical pathways and targeted therapies in basal cell carcinoma: A systematic review
... Basal cell carcinoma (BCC) is the most common type of human ...Basal Cell Nevus Syndrome (BCNS), characterized by a predisposition to the formation of BCC and other neoplasms, and identification of the ...
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Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus
... Fig. 6. Non-cell autonomous alterations in hypothalamic progenitors in cSmo embryos. Coronal sections through the tuberal hypothalamus of control and cSmo embryos at E14.5 (tamoxifen administered at E10.5). (A) ...
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Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... potential cell-extrinsic factors in the pial surface might act on a subset of SmoA2 cells arrested in migration leading to tumor ...Alternatively, cell-extrinsic factors could attract neoplastic cells to ...
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A highlight on Sonic hedgehog pathway
... The first clinical trial, targeting Smo and so using Shh pathway inhibitor as therapy, considered several patients with recurrent or metastatic basal cell carcinoma (BCC). At that time, a preliminary study was ...
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The Role of Sonic Hedgehog in the Hypothalamus
... Bmp signaling to specify all cell types except a few corticotropes (Treier et ...for cell survival within Rathke’s pouch and to prevent agenesis of the anterior pituitary by ...Fgf signaling, ...
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The effects of sonic hedgehog signaling pathway components on non small cell lung cancer progression and clinical outcome
... The results of the present study show that Shh and Gl-1 are more highly expressed in NSCLC tissues than in nor- mal counterpart tissues.Gli1 protein was detected mainly in tumor tissues, but occasionally in nontumor ...
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The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling
... Histological examination of Gas1 mutants demon- strated a ventrally displaced pituitary gland located im- mediately adjacent to the oral ectoderm and interfering with closure of the basisphenoid bone, as seen also in ...
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Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy
... the Sonic Hedgehog (SHH) and of the WNT signaling pathway in two different regions of the primary tumor and of one inoculation metastasis compared to normal ...short-term cell culture isolated ...
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Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes
... in sonic hedgehog (SHH) can exhibit a variety of facial features ranging from cyclopia to subtle midline ...SHH signaling pathway at discrete peri- ods of embryonic development could account for the ...
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Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
... Shh signaling requires primary cilia, we used immunofluorescence to investigate if the amy- loid precursor protein (APP) localizes to the primary ...IMCD3 cell cilia ...the Hedgehog signaling ...
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