Src-homology 2 domain
Mannell, Hanna (2007): The role of Src-homology 2 domain containing tyrosine phosphatase 2 in growth factor dependent endothelial signalling and angiogenesis. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... migration 2 as well as for the later stages of this process involving organization of endothelial cells into tube-like structures followed by the extension and branching of these structures 8 ...the Src ...
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Deficiency of Src homology 2 domain–containing inositol 5 phosphatase 1 affects platelet responses and thrombus growth
... stroke. Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate second messenger into ...
10
The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase 1 and Notch signaling
... receptor 2 (VEGF-R2) activation and downstream signaling pathways required for tubular network ...between Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) and ...
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Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy
... Data analysis of the CNV beadchip experiments was conducted by using DosageMiner software (deCODE Genetics). The loss/gain analysis consisted of the follow- ing 4 steps: (1) intensity normalization and GC content ...
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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
... Age-related changes in T cell subset composition in- volve a reduced frequency/number of naïve T cells, in- creased number of memory T cells and increased proportion of CD28 - T cells, especially in the CD8 + sub- ...
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SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome
... file 2: Table ...SH2 domain proteins themselves has the potential to furnish related but distinct signaling events in responses to the same input signal (Figure ...SH2 domain proteins may vary over ...
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WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain- containing protein tyrosine phosphatase 1
... including Src family kinases, Akt (also known as protein kinase B), focal adhesion kinase (FAK), and extracellular signal-regulated kinase (ERK) ...SH2 domain-containing protein tyrosine phosphatase-1 ...
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src homology 2 domain–containing tyrosine phosphatase SHP 1 controls the development of allergic airway inflammation
... SH2 domain– containing tyrosine phosphatases, are increasingly being shown to play key roles in T cell development and signaling ...dephosphorylating src-family PTKs, such as Lck and Fyn (28), as well as ...
12
Original Article Down-regulation of MiR-365 as a novel indicator to assess the progression and metastasis of hepatocellular carcinoma
... protein Src homology 2 domain-con- taining 1 (SHC1) and apoptosis-promoting pro- tein BAX in pancreatic cancer cells [28], neuro- pilin 1 (NRP1) in malignant melanoma [37], thyroid ...
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The role of SH3BP2 in the pathophysiology of cherubism
... SH3BP2: src homology 3 binding protein 2; PH: pleckstrin homology domain; PR: proline-rich domain; SH2: Src- homology 2 domain; Tyr: Tyrosine; Glu: ...
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Phospholipase C-γ Contains Introns Shared by src Homology 2 Domains in Many Unrelated Proteins
... Many proteins with novel functions were created by exon shuffling around the time of the metazoan radiation. Phospholipase C-␥ (PLC-␥) is typical of proteins that appeared at this time, containing several different ...
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Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas
... at 2-week after tumor inoculation and over 200 mm 3 at 4-week (Figure ...at 2-week after tumor inoculation compared with those at 3-day after the inoculation (p = ...
12
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
... of homology termed Janus homol- ogy (JH) domains 1–7 ...JH1 domain, shares the features of other tyrosine kinase ...molecule src homology (SH)2Bβ, an SH-2 domain containing ...
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T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells
... the Src homology 2 (SH2) domain of the actin regulator Non-catalytic region of tyrosine kinase adaptor protein (Nck) potentially binds to TSAd phosphorylated on Tyr 280 (pTyr 280 ) and pTyr ...
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SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer
... that Src homology phosphotyrosyl phos- phatase 2 (SHP2) is an essential downstream effector of EGFR signaling ...phosphatase domain in the C- terminal region ...
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Participation of Morphofunctional Zones in Aging Processes
... expressing Src kinase in its ...enough Src kinase and RhoA level, and the abundant expression of the lat- ter occurs at maximum ovulatory LH ...low Src expression in granulosa cells and in oocyte ...
7
Sterol carrier protein-x gene and effects of sterol carrier protein-2 inhibitors on lipid uptake in Manduca sexta
... the 2/3-oxoacyl- CoA thiolase domain (forward primer: xNF; reverse primer: MsSCP-CR4) were used for the PCR reaction (the expected PCR product was 151 bps; ...
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Human resistin and the RELM of Inflammation in diabesity
... head domain also consists mainly of an α-helical coiled-coil ...sequence homology of the two proteins, as well as location and functional differences of mouse and human ...
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Sequence of the Long Terminal Repeat and Adjacent Segments of the Endogenous Avian Virus Rous-Associated Virus 0
... A direct comparison of the sequences between src and the LTR of SR-A with the region between env and the LTR of RAV-0 reveals a region of homology beginning at the LTR of about 120 base [r] ...
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Cytoskeletal signaling proteins : complex regulatory mechanisms and roles in innate immunity
... FERM domain with lipids was further validated using a vesicle co- sedimentation ...FERM domain bound poorly to PE/PC vesicles, approximately 50% of the FERM domain bound to vesicles containing 1% ...
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