STAT signal
Impaired JAK STAT signal transduction contributes to growth hormone resistance in chronic uremia
... hepatic STAT tyrosine phosphorylation follow- ing a single intravenous GH ...the STAT molecules are exclusively phosphorylated by JAK2 in response to GH, the deficient STAT phosphorylation in the ...
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Porcine Reproductive and Respiratory Syndrome Virus Nsp1β Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin-α1 Degradation
... translocation mainly involves KPNA1, which functions as an adaptor protein to bind karyopherin- in transferring proteins from the cytoplasm into the nucleus. Initially, we tested whether the interaction of STAT1 and ...
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Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction
... )-induced STAT signal transduction pathway leading to activation of the ISGF3 transcription complex and subsequent antiviral responses is the target of viral pathogenesis ...for STAT protein degra- ...
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JAK STAT signaling in asthma
... A second inhibitor of Jak-Stat signaling implicated in atopic immune responses is Bcl-6, the product of a putative protooncogene that is rearranged or mutated in non-Hodgkin lymphomas. Normally, Bcl-6 func- tions ...
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Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... kinase; STAT, signal transducer and activator of transcription; GHR, growth hormone receptor; IL-2R, interleukin 2 receptor; Treg, regulatory T cell; NK, natural killer; SDS, SD score; EBV, Epstein-Barr ...
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STAT inhibitors for cancer therapy
... of STAT signal- ing induces growth arrest in several cancer models, sug- gesting their role as point of convergence from multiple upstream oncogenic pathways ...on STAT activity than their normal ...
11
Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNα
... IFNα-induced signal transduction path- ways in myeloma ...JAK/STAT signal transduction pathway mainly contributed to the different response of myeloma cells to ...
6
Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family
... RTKs: receptor tyrosine kinases; EGFR: epidermal growth factor receptor; STAT: signal transducer and activator of transcription; TKIs: tyrosine-kinase inhibitors; MRIN: membrane receptor[r] ...
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Attenuation of murine antigen induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1)
... to STAT-1 decoy ODN application may explain the attenuated arthritic symptoms in our AIA ...the STAT-1 decoy ODN observed in AIA might be due to the impaired CD40-dependent activation of macro- phages in ...
13
Tyrosine kinases in rheumatoid arthritis
... The role of NF-B in the pathogenesis of RA has been described previously. Mice lacking functional NF-B- inducing kinase have been shown to be resistant to anti- gen-induced arthritis [46]. Constitutively active ...
7
Signal Transducers and Activators of Transcription (STAT) Family Members in Helminth Infections
... named Signal Transducers and Activators of Transcription (STAT) that initiate the transcriptional activation of different genes are also involved and regulate downstream the JAK/STAT signaling ...
11
Benchmarking Quality of Experience (QoE) offered by Mobile Network Operators in Kenya: A User-Centric Approach.
... In this paper, we describe the mobile phone application developed, present the results obtained during the experiment process and do a discussion of the results. The results from the study could be used by consumers to ...
10
Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome uncovered through gene expression meta analysis
... In this context, independent studies of SLE, RA and/or SjS have shown that overexpression of type I IFN-related genes is very consistent [28-31,33,34], and it appears that these genes roughly form a common pattern in all ...
8
Impact of Bisphenol A (BPA) and Free Fatty Acids (FFA) on Th2 Cytokine Secretion from INS 1 Cells
... As signal transduction PI3K Wortmannin-sensitive and STAT-3/6 Tofacitinib-sensitive are involved in various effects, INS-1 cells release several cytokines due to BPA and FFA attack which[r] ...
10
Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy
... IHC: Immunohistochemistry; IPI: Ipilimumab; JAK/STAT 3: Janus kinase/signal transducer and activator of transcription 3; LGG: Low-grade glioma; mAb: Monoclonal antibody; MDSCs: Myeloid-d[r] ...
10
Inovarea Stat si Corporatii
... In an OECD report in 1997, measurement and evaluation of a national innovation system is centered around four types of information flows [13]: a interactions between businesses technical[r] ...
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Hippocampal Atrophy Is Associated with Altered Hippocampus–Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
... Intrinsic functional connectivity iFC between brain regions represents the synchronization of blood oxygenation level– dependent signal fluctuations in MR imaging during the resting stat[r] ...
7
Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway
... of STAT-3 signalling in APCs resulted in priming of antigen-specific CD4 + T ...of STAT-3 signalling in either direction (blockade or stimulation) influenced immune responses explaining that STAT-3 ...
7
Genetic Variability and Significance of STAT Gene in Dairy Animals
... of STAT expression by effectors of adipocyte differentiation in animals ...of STAT in different tissues and at different developmental stages have shown that STAT1 and STAT3 are constitutively expressed at ...
6
Determinants of the recent growth surge in Africa: what changed since mid 1990s?
... Notation constant t-stat y2000 t-stat inv t-stat roads t-stat hcp t-stat hcs t-stat hclife t-stat hclt t-stat icp t-stat icg t-stat icl t-stat icc t-stat icv t-stat icr t-stat inf t-stat[r] ...
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