STAT, signal transducer and activator of transcription
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
... more signal transducer and activator of transcription (STAT) factors was abnormal in cells from CLL ...any STAT in CLL ...The STAT serine kinase in CLL cells has not been ...
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Attenuation of murine antigen induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1)
... target transcription factor, thus preventing its binding to specific regulatory sequences in the promoter of its target genes and thereby effectively inhibiting its ...a STAT-1 decoy ODN with a binding site ...
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Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
... the STAT family (Stat1) to first be phosphorylated and dimerized by the IFN-γ–receptor complex and then to translocate to the nucleus and selectively transactivate genes containing a Stat1 binding site (1, ...
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Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... kinase; STAT, signal transducer and activator of transcription; GHR, growth hormone receptor; IL-2R, interleukin 2 receptor; Treg, regulatory T cell; NK, natural killer; SDS, SD score; ...
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Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction
... three signal transduction pathways, seven potential components of the pathway itself, and six putative downstream pathway target ...important signal transduction ...
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Signal transducer and activator of transcription 1 localizes to the mitochondria and modulates mitophagy
... The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, ...
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Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
... Signal transducer and activator of transcription 3 (STAT3) is a member of a protein family of transcription factors, which was discovered in the course of studies of inter- ...
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Inflammatory cytokines and atrial fibrillation: current and prospective views
... of transcription (STAT) pathway, which has never been characterized in the ...of signal transducer and activator of transcription 3 (STAT3) through a Ras-related C3 botulinum ...
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Baseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1 year treatment response in early rheumatoid arthritis
... the signal transducer and activator of transcrip- tion (STAT) transcription factors as biomarkers of disease activity and treatment response in RA ...
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Expression of activated signal transducer and activator of transcription 3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma
... The STAT family of tran- scription factors is involved in several cellular processes, such as proliferation, survival, apoptosis, and differenti- ation [17, ...
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Genetic Variability and Significance of STAT Gene in Dairy Animals
... bovine signal transducer and activator of transcription (STAT) gene has increased due to involvement of STAT1 in the development of the mammary gland and regulating the ...
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Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma
... The distribution of p-STAT-3 positive cells was summarized by the mean, standard error and range. Due to the limited number of observations in murine models, the comparison of p-STAT-3 positive cells was ...
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Checkpoint inhibitors in hematological malignancies
... On the other hand, relatively homogenous expression of PD-L1 is present by intrinsic signals. So far, four mechanisms in intrinsic signals have been reported in lymphoid neoplasms. Firstly, copy number alterations ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: low‑density lipoprotein; LpL: lipoprotein lipase; LPS: lipopolysac‑ charide; MA: ...
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Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome uncovered through gene expression meta analysis
... In this context, independent studies of SLE, RA and/or SjS have shown that overexpression of type I IFN-related genes is very consistent [28-31,33,34], and it appears that these genes roughly form a common pattern in all ...
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Signal Transducer and Activator of Transcription 4 in Liver Diseases
... STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a tran- ...
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Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy
... IHC: Immunohistochemistry; IPI: Ipilimumab; JAK/STAT 3: Janus kinase/signal transducer and activator of transcription 3; LGG: Low-grade glioma; mAb: Monoclonal antibody; MDSCs: Myeloid-d[r] ...
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RNA virus modulation of IFN, PI3K and apoptosis
... The previous section reported that the STAT1-degradative function of V was responsible for inhibiting apoptosis caused by non-viral inducers. It was next determined whether V contributed to apoptosis regulation during ...
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Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene ( IRF1 )
... Additional file 1: Western blotting of histones acid extracted after treatment with 5 ’ -deoxy-5 ’ -methyl-thioadenosine (MTA), carbobenzoxy-L-leucyl-L-leucyl-L-leucinal (MG132), and RNAi- mediated knockdown of RNF20 and ...
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Original Article Clinical significance and prognostic value of STAT3 expression in patients with diffuse large B-cell lymphoma treated with rituximab-CHOP therapy
... transcription 3 (STAT3) activation has been proved to be associated with certain subtypes of DLBCLs, especially ABC like DLBCLs [7, 8]. STAT3 is an important member of the Janus kinase (JAK) and signal ...
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