Stem cell-mediated bone formation in osteoporosis
Do stem cells transfected with CXCR4 enhance bone formation in osteoporosis?
... deteriorating bone structure of the OVX rat model was clearly observed as the Time 0 control rats had the most bone volume and density compared to the rest of the OVX rats which were treated for a further ...
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BMP signaling in mesenchymal stem cell differentiation and bone formation
... ABSTRACT Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have diverse functions during development and ...and bone forma- tion, and disruptions in BMP signaling cause a vari- ety ...
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Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
... of cell fate ...the cell morphology; specifically, wider spindle- shaped cells correspond with denser MSCs ...cartilage formation from MSCs in vitro, and increase the efficiency of MSC ...
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Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein 4
... in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or ...
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Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation
... however, after passaging during long-term culture, most of the bone marrow-derived MSCs lose their potential to differentiate into multiple lineages as well as self-renewal capacity. Although RSV treatment is ...
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Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration
... in bone regeneration via stem ...the bone regenerative capacity of old hMDSCs in vivo was not ...impaired bone regener- ation ...affect bone regeneration of old hMDSCs may be due to the ...
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Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration
... mesenchymal stem cell differentiation, we sought to characterize the influence of microgravity mechan- ical unloading on the cellular composition and arrangement of cells within the bone marrow ...in ...
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Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass.
... coupling bone resorption and endogenous stem cell recruitment to bone 35 ...to bone, which indicates a breakthrough in the application of using transplanted MSCs to augment bone ...
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Osteoporosis: the current status of mesenchymal stem cell-based therapy
... of bone remodeling, together with associated pathologic ...of osteoporosis involves an imbalance of bone homeostasis that results from many causes, such as hormone deficiency, genetic disorders, use ...
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Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation
... reduced bone formation, whereas bone resorption is nearly ...stimulating bone formation is an- other way of treating osteoporosis ...osteoblastic bone development and ...
5
Semen astragali complanati and rhizoma cibotii enhanced bone formation in osteoporosis rats
... of osteoporosis has been well documented for long history in ...increased bone formation by stimulating OPG expres- sion and downregulating RANKL in bone marrow cells ...for ...
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Diabetic Bone Marrow & Stem Cell Dysfunction
... novo formation of blood vessels from precursor ...the formation of the earliest vascular plexus, after which angiogenesis was originally believed to take over as the predominant mechanism of vessel ...
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Bone marrow cell-mediated production of transgenic chickens
... marrow cell-mediated production of transgenic chickens Young Tae Heo 1 , Sung Ho Lee 1 , Ji Hoon Yang 1 , Teoan Kim 2 and Hoon Taek Lee 1 The transplantation of adult stem cells into recipients is a ...
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Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin overexpressing mice
... sion in the macrophage is yet to be established, but it is possible that it may modulate the known effects of BMP on osteoclast formation (30). We next examined the regulation of noggin expres- sion in ...
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Improving Bone Formation in Osteoporosis Through In Vitro Mechanical Stimulation Compared to Biochemical Stimuli
... mesenchymal stem cells (MSCs) to ...and osteoporosis to be associated with alterations in biochemical pathways,[19-21] while mechanotransduction pathways, on the other hand, remain ...osteoporotic ...
5
Biological Characteristics of Foam Cell Formation in Smooth Muscle Cells Derived from Bone Marrow Stem Cells
... are mediated by various cytokines and growth factors and also depend on the degradation of extracellular matrix by proteinases such as matrix ...the formation of atheroscle- rotic ...promoted cell ...
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Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss
... trabecular bone of our model at 2 weeks ...trabecular bone de- creased, the level of OCN in the serum was increased at 2 weeks post-irradiation, suggesting that radiation exposure did not compromise the ...
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Redox control of IL-6-mediated dental pulp stem cell differentiation on alginate/hydroxyapatite biocomposites for bone ingrowth
... 5. Conclusions Taken together, our results partly present the molecular mechanisms underlying the biological processes of DPSC differentiation in parallel with the escape from oxidative stress. In the present work, we ...
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<p>Increased Osteoblastic Cxcl9 Contributes to the Uncoupled Bone Formation and Resorption in Postmenopausal Osteoporosis</p>
... the bone formation and resorption through direct cell-cell contact, cytokine or cell-bone ...on bone formation and ...
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Differential expression of genes associated with hypoxia pathway on bone marrow stem cells in osteoporosis patients with different bone mass index
... in bone marrow of OP patients causes decreased DEC1 expression, which might affect the differentiation of BMSCs, further leading to decreased bone ...of cell proliferation and survival, cell ...
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