streptozotocin diabetic rat
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
... In control rats (n=6), von Frey testing gave values of 14±0.6g, 14.9±0.7g and 15.6±0.7g after 0, 12 and 24 weeks. Tactile allodynia developed in STZ-diabetic rats (n=14) after 7- 10 days and reached a maximum ...
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Cyclic nucleotide metabolism in the streptozotocin diabetic rat corpus cavernosum; Relevance to human diabetic erectile dysfunction
... of diabetic complications (Nishimura et al, ...STZ diabetic rat model there was no benefit of aldose reductase inhibition on either vasoreactivity or prostacyclin release, suggesting that these ...
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Glomerular basement membrane: biosynthesis and chemical composition in the streptozotocin diabetic rat
... experiments, and labeled hydroxylysine accounted for a lower portion of the total counts in the medium (0.85%) than in the GBM (1.98%). Isolated glomeruli were prepared from streptozotocin diabetic rats of ...
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Abnormal cardiac function in the streptozotocin diabetic rat Changes in active and passive properties of the left ventricle
... constant was decreased. However, "operating chamber stiffness" calculated at end-diastolic pressure was increased at 7 d, and unchanged at 26 d. LV cavity/wall volume and end- diastolic volume were increased ...
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Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rat
... The present study evaluated the effect of methanolic extract of Truffle and Balanites aegyptiaca on the FBG level; the changes in pancreatic histology as well as the changes in iNOS and IL-1β gene expression level among ...
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Phytochemical and pharmacological studies of L eptadenia pyrotechnica
... The Plant extracts also effectively prevented the atheromatic changes and plaque formation in the . Hepatic and aortic total cholesterol, lipid peroxidation and triglycerides were also lowered considerably in the rabbits ...
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Choosing preclinical study models of diabetic retinopathy: key problems for consideration
... Abstract: Diabetic retinopathy (DR) is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many ...
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Role of GABAB Receptor and L-Arg in GABA- Induced Vasorelaxation in Non-diabetic and Streptozotocin-Induced Diabetic Rat Vessels
... in diabetic patients, and hypertension is also considered as an independent risk factor for cardiovascular mortality in such patients ...in diabetic patients [3, ...
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HYPOGLYCEMIC AND ANTI DIABETIC EFFECT OF ALTERNANTHERA SESSILIS IN NORMAL AND STREPTOZOTOCIN (STZ)-INDUCED RAT
... of streptozotocin (STZ) (70 mg/kg body weight) in ...the streptozotocin induced hypoglycemic mortality, 5% glucose solution was given for 24 h to streptozotocin treated ...
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Evaluation of Antidiabetic Activity of Isolated Compound from Ougeinia oojeinensis Bark Extract in Diabetic Rats
... Diabetes mellitus is metabolic diseases and characterized by hyperglycemia that leads from absolute or relative deficiency of insulin secretion, impaired insulin action, or both. There are numerous factors that enhance ...
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Investigation Into Mechanism of Action of Anti-Diabetic Activity of Emblica Officinalis on Streptozotocin Induced Type I Diabetic Rat
... STZ-diabetic rats were found to exhibit significant hyperglycemia (Fig 3A) with a corresponding hypoinsulinaemia (Fig 3B) as compared to control rats. Treatment with fresh juice (5ml/ kg/p.o./day) and ...
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Ruscogenin ameliorates diabetic nephropathy by its anti inflammatory and anti fibrotic effects in streptozotocin induced diabetic rat
... STZ-diabetic rats in the treatment group were dosed with 0.3, 1.0 or 3.0 mg/kg ruscogenin (≥ 98%; Chengdu Biopurify Phytochemicals Ltd., Chengdu, Sichuan, China; Cat. No. 472-11-7) in distilled water (1.5 ml/kg) ...
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Antidiabetic activity of stem extracts of Tinospora cordifolia on streptozotocin induced diabetic Wistar rat
... The aim of the present experiment was to evaluate therapeutic efficacy of stem extracts of Tinospora cordifolia on diabetes induced animal model Wistar rat. Experimental animals were grouped in to control (I), ...
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DIABETIC NEPHROPATHY AND HERBAL MEDICINES
... pathogenesis of diabetic nephropathy (Osama et al., 2009). Propolis and its extract have anti-oxidant properties. Oral administration of propolis extract in doses of 100, 200 & 300 mgs/kg body weight improved ...
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Hypoglycemic and Antihyperglycemic Activity of Methanolic Root Extract of Ficus Racemosa in Normal and Streptozotocin-Induced Diabetic Rats.
... The study was undertaken to evaluate the hypoglycemic and antihyperglycemic activity of methanolic root extract of Ficus racemosa (Family: Moraceae) following oral administration (100, 200 and 400 mg/kg body weight) to ...
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In-Vivo Studies on Anti-Diabetic Potential of Leucas Aspera in Streptozotocin Induced Diabetic Wistar Albino Rats
... of Streptozotocin (50mg/kg) dissolved in ...of Streptozotocin (120 mg/kg) after 15 ...be diabetic and were used for further diabetic ...
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Evaluation of Antidiabetic Activity of Polyherbal Formulation in Streptozotocin-Induced Diabetic Rats
... acarbose, miglitol and voglibiose, sulphonylureas, biguanides etc are used for the ailment of hyperglycemia. The synthetic drugs are associated with various side effects such as causing hypoglycemia at higher doses, ...
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Scientific validation of anti-diabetic, antidyslipidemic and anti-oxidant activities of siddha herbal formulation “Elathy Urundai” in in-vivo and in-vitro models
... Giving bovine insulin along with CFA to guinea pigs produces anti-insulin antibodies. Intravenous injection of 0.25-1.0 ml guinea pig anti-insulin serum to rats induces a dose dependent increase in blood glucose levels ...
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Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin and BB/Wor diabetic rats Immunodetection of Gs and Gi with antisera prepared against synthetic peptides
... fluoroaluminate, and cholera toxin. Basal or forskolin-stimulated activity was unchanged in STZ rats, but increased in BB/Wor rats. No change in the alpha-subunit of Gi (alpha i) was observed in STZ or BB/Wor rats using ...
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Decreased Glucagon Receptors in Diabetic Rat Hepatocytes: EVIDENCE FOR REGULATION OF GLUCAGON RECEPTORS BY HYPERGLUCAGONEMIA
... In streptozotocin diabetic rats, blood glucose and plasma glucagon increased and plasma insulin decreased as compared with ...in diabetic rats restored blood glucose and plasma glucagon toward normal ...
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