Stress-induced premature senescence
Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
... of premature senescence, we used low doses of H 2 O 2 as a stressor to induce premature senescence in HEI-OC1 auditory ...induce premature senescence in other cell types as well, ...
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Aging with ING: a comparative study of different forms of stress induced premature senescence
... cellular senescence. Cells also show many senescence- associated phenotypes as a consequence of physiological ...of senescence is called stress-induced premature ...
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Caveolin 1 expression and stress induced premature senescence in human intervertebral disc degeneration
... oxidative stress and catabolic cytokines, which have been implicated in the induction of SIPS ...oxidative stress [35]; therefore, its presence and that of its receptor RAGE are highly significant for both ...
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Purinergic P2Y14 receptor modulates stress induced hematopoietic stem/progenitor cell senescence
... (IR- induced) damage. While IR can result in either apoptosis or senescence, it has been suggested by some that stress-induced premature senescence (SIPS) may predominate over ...
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Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/ EGFR/RB signal pathways
... However, stress-induced premature (SIP) senescence of EPCs caused by oxidative stress related to coronary artery disease and diabetes can impair their function, leading to harmful ...
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Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
... cellular senescence characteristic of G6PD-deficient fibroblasts would seem to represent a clear case of a senescence mechanism based on accumu- lated oxidative DNA damage rather than one involving ...
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MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence
... to stress conditions, including ultraviolet (UV) irradiation, starvation, and misfolded protein ...ultraviolet-induced premature senescence and AMBRA1 is a rate-limiting miRNA target in this ...
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RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
... oxidative stress, SHC proteins are also implicated in the process of premature senescence of HUVECs induced by high-glucose (Supplemental Figure ...high-glucose-induced premature ...
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Original Article Initiation of premature senescence by Bcl-2 in hypoxic condition
... that senescence could be induced prematurely when cells encounter telo- mere shortening, gene mutations, and stress [2, ...of senescence-associated beta-galactosi- dase and enhanced expression ...
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Original Article Guiqi polysaccharide protects the normal human fetal lung fibroblast WI-38 cells from H
... -induced premature senescence in normal human fetal lung fibroblast WI-38 ...premature senescence. Morphological observation, MTT assay, senescence-associated β-galactosidase ...
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Elevated miR-34c-5p Mediates Dermal Fibroblast Senescence by Ultraviolet Irradiation
... ultraviolet stress treatment, the expression of interstitial collagenase/matrix metallo- proteinase-1 is ...cellular senescence, suggesting that miR-34c-5p may also be involved in photoaging of the ...
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Gadd45b deficiency promotes premature senescence and skin aging
... as stress sensors in response to various physiological and environmental ...increased senescence in Gadd45b null MEFs is partially reversed by culturing at physiological oxygen levels, indicating that ...
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Oxidative stress and premature senescence in corneal endothelium following penetrating keratoplasty in an animal model
... cell senescence and cell death, including p38 MAPK ...of stress-induced cell senescence ...that stress-activated ASK1 accelerates endothe- lial cell senescence in patients with ...
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17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway
... increase disc height in postmenopausal women. Theoretically, two mechanisms are responsible for cellular senescence: the telomere-based p53-p21-pRB pathway and the stress-based p16-pRB pathway [51]. ...
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Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome
... cellular senescence and nuclear dysmorphies, with nuclear blebs showing abnormal nuclear staining of A and B-type lamins ...oxidative stress and cellular senescence were enhanced in WRN-mutated ...
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Role of calcium and mechanical damage in the development of localised premature softening in coolstored kiwifruit : a dissertation presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Plant Science at Massey University
... of premature softening between different pack-types require further investigation so that packaging aspects of storage practices can be adapted to take advantage of any ...
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Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
... of senescence-associated heterochromatin foci (SAHF), a senescence marker that can be visualized as punctate nuclear focus when staining cells with DAPI or antibodies against K9 trimethylated histone 3 ...
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Senescence associated SIN3B promotes inflammation and pancreatic cancer progression
... Nevertheless, in an Ink4a/Arf-deleted mouse model, absence of SIN3B did not confer a survival advantage and Sin3B deleted pancreata developed PDAC to the same extent as control ani- mals demonstrating the requirement of ...
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Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
... cellular senescence and we propose that it could be due to the activation of ...cellular senescence in vitro, it cannot be excluded that it may act differently in ...cellular senescence and aging ...
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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs
... S3), whereas activation of mTORC1 via MHY1485 miti- gated the Dox-induced expression of H3K9me3 and HP1γ (Fig. 5d, e). In line with the cell models, the link between mTORC1 and heterochromatin changes was re- ...
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