structural and mechanistic insights
Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
... (2017) Structural/mechanistic insights into the efficacy of nonclassical β lactamase inhibitors against extensively drug ‐ resistant Stenotrophomonas maltophilia clinical ...
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Structural and Mechanistic Insights into the Yeast Disaggregase Hsp104
... conformations of a variety of amyloid forming proteins indicates that there are common structural elements within the amyloidogenic oligomers [63]. When spontaneous amyloid formation is tracked over time (i.e. in ...
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Comparative Analysis of Novel Targets for Antimalarial Drugs: Structural and Mechanistic Insights about Plasmodium falciparum Enzymes
... Malaria is the main cause of death rate attributable to a communicable disease. Antimalarial drug resistance seems to be the greatest force against ruthless battle of malaria. Resistance against antimalarial drugs ...
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Modeling the human Na<sub>v</sub>1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade
... Although the present study has been carefully conducted, it is important to acknowledge that there are some limitations that are mainly due to the lack of good templates and to our efforts to minimize computational costs ...
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Structural and Mechanistic insights into Centromere Specification and Kinetochore Regulation
... There is now nearly a consensus on the point that recombinant, purified CENP-A readily assem- bles into octameric nucleosomes where two copies of CENP-A replace the two copies of canonical H3 [62–64, 77, 239]. ...
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Structural and mechanistic insights into s-block bimetallic catalysis : sodium magnesiate-catalyzed guanylation of amines
... FULL PAPER Entry for the Table of Contents Please choose one layout Layout 1: FULL PAPER Magnesium activATES: Showing enhanced catalytic ability compared to their homometallic components[r] ...
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Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
... Our structural, kinetic and whole bacterial killing data would lead to the conclusion that ceftazidime was probably superfluous in this success, but our work indicates that ceftazidime/avibactam plus aztreonam ...
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Metabolic diseases and pro- and prebiotics: Mechanistic insights
... Metabolic diseases, such as obesity and type 2 diabetes, are world-wide health problems. The prevalence of metabolic diseases is associated with dynamic changes in dietary macronutrient intake during the past decades. ...
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New Mechanistic Insights: Why Do Plants Produce Isoprene?
... Final energies are corrected using the AP approach as described above, whenever the reacting species (including reactants, products, and transition states) attain a biradical character. As an initial accuracy benchmark, ...
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Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum Sensing Transcription Regulator
... activity. Structural comparison between SdiA-AHL and SdiA-OCL complexes provides crucial mechanistic insights into the ligand regulation of AHL-dependent and -independent function of LuxR-type pro- ...
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Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid
... main structural domains of the HAstV CP: the core domain at ...molecular insights into HAstV that have practical applications for the development of vaccines and antiviral ...
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RNA interference: new mechanistic and biochemical insights with application in oral cancer therapy
... The targeted delivery of a complex composed of CIP2A siRNA, EGFR binding-peptide, and an endosome-disruptive peptide was proven to silence more efficiently the CIP2A oncogene, in vi[r] ...
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Structural Insights into Human Bocaparvoviruses
... Utilization of the HBoV structure information for HBoV-based gene therapy vectors. Similar to recombinant AAVs, efforts to develop HBoV capsids as vectors for potential gene therapy applications are under way (58). The ...
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ANTIPARKINSONIAN EFFECTS AND MECHANISTIC INSIGHTS OF SOME INDIGENOUS HERBAL FORMULATIONS
... TABLE 9: EFFECT OF FORMULATIONS ON HANGING WIRE TEST Group Drug Treatment I Vehicle control II Negative control: treated with Reserpine 1mg/kg, i.p.. VI Standard Levodopa + Carbidopa 110[r] ...
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Molecular and Structural Insights into Nuclear Hormone Receptor Repression Mediated by the Corepressor NCOR
... Structural studies of receptor DBD:DNA complexes for TR-RXR as well as Rev-erb homodimers also provided evidence for additional sites of protein-DNA interaction and specificity. RXR-TR structures revealed the ...
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Symmetrical Catalytically Active Colloids Collectively Induce Convective Flow
... 89 Against this background, here we focus on exploring the 90 motion of homogeneous catalytically active colloids coated with 91 platinum decomposing dissolved hydrogen peroxide fuel. The 92 aim of these experiments is ...
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Mechanistic Insights into the Cure of Prion Disease by Novel Antiprion Compounds
... nistic insights for the development of other novel therapeutic agents by highlighting cellular mechanisms that can be altered to accelerate the destruction of prions by ...
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Structure-Property Relationships of Copper(I) Tetrachloroaluminate and Related Compounds.
... Solid-state chemistry is moving beyond classical descriptive crystal chemistry to the study of the dynamic processes that inter-relate structural classifications. A dynamic view of solids is driven in part by the ...
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Mechanistic Insights into the Enhancement of Adeno-Associated Virus Transduction by Proteasome Inhibitors
... As carfilzomib and bortezomib demonstrate similar rAAV transduction enhancement in vitro, we tested carfilzomib’s ability to enhance rAAV2 transduction in vivo to determine whether prote[r] ...
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Mechanistic Insights into the Efficacy of Sodium Bicarbonate Supplementation to Improve Athletic Performance
... The mechanisms identified have been broadly categorised under the sections ‘ Whole-body Metabolism ’ , ‘ Muscle Physiology ’ and ‘ Motor Pathways ’ , and when possible, the performance o[r] ...
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