• No results found

succinyl-CoA synthetase

Interaction between succinyl CoA synthetase and the heme biosynthetic enzyme ALAS E is disrupted in sideroblastic anemia

Interaction between succinyl CoA synthetase and the heme biosynthetic enzyme ALAS E is disrupted in sideroblastic anemia

... The first and the rate-limiting enzyme of heme biosynthesis is δ-aminolevulinate synthase (ALAS), which is localized in mitochondria. There are 2 tissue-specific isoforms of ALAS, erythroid-specific (ALAS-E) and ...

9

Measurement of δ Aminolevulinic Acid Synthetase Activity in Human Erythroblasts

Measurement of δ Aminolevulinic Acid Synthetase Activity in Human Erythroblasts

... (ALA) synthetase activity in human bone marrow cells has been ...ALA synthetase of erythroblasts was partially purified so as to permit the use of [ 14 C]succinyl-CoA as a substrate for this ...

10

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

... glutamicum, succinyl-CoA synthetase was mutated to couple the TCA cycle and the lysine synthesis pathway, leading to a ...of succinyl-CoA ...feeding succinyl-CoA into the ...

12

Molecular Expression and Characterization of Erythroid-Specific 5-Aminolevulinate Synthase Gain-of-Function Mutations Causing X-Linked Protoporphyria

Molecular Expression and Characterization of Erythroid-Specific 5-Aminolevulinate Synthase Gain-of-Function Mutations Causing X-Linked Protoporphyria

... succinyl CoA, with the other being ...of succinyl-CoA synthetase binding were found in different patients with X- linked sideroblastic anemia, indicating these were loss-of-function ...

8

Acyl-CoA synthetase isoform 1 deficiency impairs beta-oxidation in mouse heart and adipose tissue

Acyl-CoA synthetase isoform 1 deficiency impairs beta-oxidation in mouse heart and adipose tissue

... ACSL1 cellular location may dictate its role in FA channeling. ACSL isoenzymes are intrinsic membrane proteins present in various subcellular compartments in a tissue- specific manner. The subcellular location of ACSL1 ...

184

Chewing the fat: beta-oxidation in signalling and development

Chewing the fat: beta-oxidation in signalling and development

... acyl CoA synthetases. Acyl CoA is then converted to a 2-trans-enoyl CoA by acyl CoA oxidase (step ...-dienoyl CoA isomerase 3,19 ...3-ketoacyl CoA to yield acyl CoA and ...

29

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

... Acyl-CoA synthetase long-chain family member 4; AML: Acute myeloid leukemia; AMPK: Adenosine 5 ′ -monophosphate-activated protein kinase; ART: Artesunate; As-SLC7A11: Antisense lncRNAs; ATF4: Activating ...

16

The effect of acyl-CoA synthetase long-chain  family member 5 on triglyceride synthesis  in bovine preadipocytes

The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes

... acyl-CoA synthetase families (ACSs) that are indispens- able in the activation of fatty acids, and play a key role in mammalian metabolism of fatty acids (Nelson and Ackman, ...and CoA (coenzyme A) ...

8

Identification and characterization of levulinyl-CoA synthetase from Pseudomonas citronellolis, which differs phylogenetically from LvaE of Pseudomonas putida

Identification and characterization of levulinyl-CoA synthetase from Pseudomonas citronellolis, which differs phylogenetically from LvaE of Pseudomonas putida

... Structural comparison was carried out through homol- ogy modeling of LvaE2 from LA18T and LvaE from KT2440. The two models have features similar to acyl- CoA synthetase from Thermus thermophilus (e.g., ...

11

Grevengoed_unc_0153D_15339.pdf

Grevengoed_unc_0153D_15339.pdf

... dissertation shows that ACSL1 also plays a role in activation of fatty acids for glycerolipid synthesis and remodeling. This information could point to a lack of acyl-CoA channeling by ACSL1, especially because ...

137

WNK pathways in cancer signaling networks

WNK pathways in cancer signaling networks

... medium-chain synthetase 3; AKT: Protein Kinase B; EGF: Epidermal growth factor; EMT: Epithelial to mesenchymal transition; ENaC: Epithelial sodium channel; ES cells: Embryonic stem cells; HCC: Hepatocellular ...

6

Chemokine receptors on dendritic cells promote autoimmune reactions

Chemokine receptors on dendritic cells promote autoimmune reactions

... We tested histidyl tRNA synthetase (HisRS), the most fre- quently targeted aaRS in myositis, since 20–30% of patients have autoantibodies to it. We also tested the N- terminal coiled-coil domain of HisRS 1–48 with ...

6

Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

... Escherichia coli W was chosen for this study because it shows reasonable resistance towards acetate [14], which was also evaluated in batch cultures where growth on up to 2% (w/v) acetate as the sole source of carbon was ...

15

Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOBT)

Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOBT)

... Malate is oxidized to oxaloacetate by malate dehy- drogenase (Sfum_0460) and oxaloacetate is decarboxylated to pyruvate by pyruvate carboxyltransferase (Sfum_0461, 0676). The decar- boxylation of oxaloacetate to pyruvate ...

16

Production of 3 hydroxypropionate from biomass

Production of 3 hydroxypropionate from biomass

... Biorenewable technology is a developing field of science that researches alternative sources for petroleum products like fuels, plastics, paints, etc. The DoE biomass program has identified the 12 top chemicals that can ...

59

2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.

2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.

... To elucidate the mechanism leading to this IFN sensitivity, the expression of the 2'-5'-oligoadenylate synthetase 2-5A synthetase gene, the presence of the 2-5A synthetase protein, and t[r] ...

7

Immunohistochemical Analysis of Citrulline Nitric Oxide Cycle Enzymes and Glutamine Synthetase in Different Regions of Brain in Epilepsy Rat Model

Immunohistochemical Analysis of Citrulline Nitric Oxide Cycle Enzymes and Glutamine Synthetase in Different Regions of Brain in Epilepsy Rat Model

... oxide synthetase, argininosuccinate synthetase, argininosuccinate lyase, glutamine synthetase in different regions of brain in rats of kainic acid mediated ...succinate synthetase and ...

9

How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?

How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?

... At present, no structural data are available for ABCD proteins but homology modelling has offered insights into their architecture. Modelling CTS on the ‘gold standard’ Sav1866 2HYD structure of Dawson and Locher [46] ...

10

Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells

Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells

... Acyl-CoA synthetase long-chain family member 1; ACSS2, Acyl-CoA synthetase short-chain family member 2; AGPAT6, 1-acylglycerol-3-phosphate O-acyltransferase 6; DGAT1, diacylglycerol ...

11

Using the pimeloyl CoA synthetase adenylation fold to synthesize fatty acid thioesters

Using the pimeloyl CoA synthetase adenylation fold to synthesize fatty acid thioesters

... Figure 1. The BioW reaction highlighting its role in biotin biosynthesis and the activity of wild type BioW with various fatty acid substrates. (A) The enzyme pimeloyl-CoA synthetase (BioW) catalyses the ...

38

Show all 1055 documents...

Related subjects