T cell activation and differentiation
Plasticity of DNA methylation in mouse T cell activation and differentiation
... + T cells are a highly flexible, mixed and dynamic population. The CD4 + T cell popula- tion is a mixture of naive (CD44 - CD62L + ), memory/effec- tor (CD44 + CD62L +/- ) and regulatory cells (CD4 + ...
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Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell Analysis
... In T cells, T cell receptor (TCR) signaling initiates downstream transcriptional mecha- nisms for T cell activation and ...regulatory T cells (Treg) require TCR signals ...
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Ubiquitylation Regulates Cd4+ T Cell Activation and Effector Differentiation to Shape the Immune Response
... ligase activation a self-terminating signal—Ndfip1 is upregulated, interacts with Nedd4 family E3 ligases to promote their activity, and, in so doing, is itself rapidly ...regulating T cell ...
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One naive T cell, multiple fates in CD8+ T cell differentiation
... the T cell population level, which precludes conclusions on the devel- opmental potential of single naive T ...naive T cells at the single-cell level, we have developed a technology in ...
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Signals Controlling Regulatory T Cell Differentiation and Homeostasis
... all T cells with calcineurin inhibitors such as cyclosporine and ...of T cell activation and thus IL-2 ...prevent T cell ...STAT5 activation, are sufficient to ensure Treg ...
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Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis
... diet, T cell–specific ABCG1 deficiency protected against atherosclerotic ...Furthermore, T cell–specific ABCG1 deficiency led to a 30% increase in Treg percentages in aorta and aorta-draining ...
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B Cell Generation, Activation & Differentiation. B cell maturation
... stromal cell molecule called stem-cell factor (SCF), and this activates ...B cell begins to divide and expresses receptor for ...B cell is released (still requires IL-7 for growth and ...
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Monocyte-Induced Regulatory T Cell Differentiation
... The Role of CD36 in UCB Treg Differentiation. High expression of CD36 marks the monocytes capable of inducing Tregs, yet we lack evidence that CD36 itself is required for Treg differentiation. Multiple ...
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Involvement of MicroRNA in T-Cell Differentiation and Malignancy.
... HTLV-1-positive T-cell line, and Tax protein is involved in this increased ...adult T-cell leukemia/lymphoma (ATLL) 87 ...positive T-cells(88). Activation of NF-κB pathway is a ...
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Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation
... B cell activation, proliferation, and ...as activation and proliferation of high-dose anti-mu or Staphylococcus aureus-stimulated B cells are profoundly suppressed by the presence of in vitro ...
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Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation
... changing cell fate by serving as a ‘molecular switch’ for regulatory ...additional cell types, PDT-induced differentiation could be useful in multiple ...promote differentiation by exposing ...
12
Notch1 Modification and Signaling in T Helper Cell Differentiation
... 11 activation mechanisms, the differences in experimental models could have affected Notch at different stages causing a specific ...of T helper cells 137-139 ...for T h 1 differentiation and ...
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Transcriptional Regulation of T Helper 17 Cell Differentiation
... γ t and ROR α and forms hetero- dimers with retinoid X receptors (RXRs) to bind to the gene ...γ activation upon ligand binding is criti- cal for the expression of genes such as adiponectin and fatty ...
8
Differentiation and activation phenotypes of lung T lymphocytes differ from those of circulating T lymphocytes
... with activation and with differentiation in lung and peripheral blood T lymphocytes from normal ...subjects. T cell subsets, defined based on their reactivity with monoclonal antibodies ...
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Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation
... ⫹ T-cell-deficient C3H mice, we observed a dissoci- ation between cytokine and cytotoxic activities by PyV-specific effector CD8 ⫹ T ...⫹ T cells produced IFN- ␥ and degranulated upon cognate ...
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mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
... and differentiation of CD4 + T effector cell ...+ T cell effector and memory ...a T cell–specific deletion of the gene encoding the negative regulator of mTORC1, tuberous ...
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BMP driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
... and differentiation of stem/progenitor cells, especially in tissues that are constantly replenished like the ...intestinal differentiation; however, in mice, basal progenitor cell–specific expression ...
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MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
... triggering cell cycle arrest. This activation of INK4A was required for efficient melanocyte ...cyte differentiation and cell cycle exit, and potentially explain the tissue-specific tendency ...
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T-Cell Research. Novel multicolor flow cytometry tools for the study of CD4 + T-cell differentiation and plasticity
... of cell populations. BD products facilitate the detection of cell surface markers, phosphorylated proteins, transcription factors, apoptosis markers, and ...of cell along with its activation ...
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Modelling T cell activation
... a t the kinetic proofreading model requires a long chain of fast ...TCR activation thresh old, increasing the number of steps while simultaneously increasing the rate A reduces the variance of the waiting ...
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