T-cell acute lymphoblastic leukemia (T-ALL)
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the transformation of T-cell progenitors at various ...
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...B cell line ...
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Subset derivation of T cell acute lymphoblastic leukemia in man
... blood T cells can be characterized as belonging to either the TH+2 or TH-2 T-cell ...of T cells are TH+2, whereas 80% are TH- 2 utilizing specific ...human T-cell acute ...
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
... with acute lympho- blastic leukemia (ALL) over the last decades ...B-lineage ALL, where new targeted therapies with monoclonal antibodies like Rituximab or small molecule tyrosine kinase ...
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Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
... various T-cell malignancies and appear to correlate with a relatively high intracellular concentration of ara-GTP compared to ...refractory T-cell acute lymphoblastic ...
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Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia
... and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic ...and acute renal failure when found in conjunction with ...
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Induction of human B cell antigens in non T cell acute lymphoblastic leukemia
... non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B ...study, ALL cells that do not express the B1 antigen were studied in ...
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... childhood ALL [7 – ...[12–15]. T- ALL patients are more likely to have a worse steroid re- sponse than B-ALL patients [8, 10, ...childhood ALL had been proved to be a remarkable ...
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SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
... of cell lines for SET/NUP214 mRNA expression was performed applying ...in T-ALL and AML patients ...GGA T-3'; NUP214 exon 18 reverse: 5'-ATC ATT CAC ATC TTG GAC AGC ...in cell lines ...
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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
... of T-ALL cells to overcome the cytotoxic effects of chemotherapy is a critical step in developing more effective ...on cell viability, we screened nearly 500 thera- peutic compounds and identified 22 ...
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The molecular basis of T cell acute lymphoblastic leukemia
... of T-ALL ...of T-ALL in transgenic mice expressing TAL1 in developing thymocytes (62, ...In T-ALL cells, TAL1 forms pri- marily inactive transcriptional complexes that contain E ...
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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM − / − thymic lymphomas [4 – ...murine T-ALLs ...
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T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ...
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PIM 2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity
... of cell apop- tosis in different tumor cell lines and could maintain cell survival independent of PI3K and Akt pathways (14, ...blocked T cell acute lymphoblastic ...
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Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement
... in leukemia has not yet been fully understood, and the related molecular mechanism is still ...from T-ALL (T-cell acute lymphoblastic leukemia) ...arresting ...
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<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... ETP-ALL, T/M-MPAL, and AML-M0 with ...ETP- ALL cases amongst T-ALL, and prevalence in patients older than 10 years of age at ...our T-ALL cohort. Another point is that the ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... in T-ALL. However, in pre-B ALL the pattern of gamma TCR usage was distinct from that of T cells, with the C gamma 1 complex utilized more ...Almost all ALLs could be classified as ...
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Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
... B cell ALL and was the first patient enrolled in this phase I clinical trial ...CAR-T cell preparation was collected ahead of mobilization, and the materials and methods to produce, detect, ...
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... Therapy-related acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...therapy-related acute ...
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Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential?
... revolutionized the treatment landscape for many advanced cancers. Notably, the use of immune checkpoint inhibitors has demonstrated durable responses in various malignancies. However, the response to such treatments is ...
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