T cell priming by professional antigen presenting cells
Priming of Cytotoxic T Lymphocytes by DNA Vaccines: Requirement for Professional Antigen Presenting Cells and Evidence for Antigen Transfer from Myocytes
... that induction of CTL responses following DNA immunization is restricted by the haplotype of the donor BM cells, indicating that BM-derived professional APCs are responsible for direct i[r] ...
10
Antigen processing and T cell priming by mouse dendritic cells
... one cell type but not another has to be confirmed as being differently expressed by Northern blot, followed by cloning and sequencing of the ...control cells of one mouse strain but not in the other; ...
216
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen presenting cells
... (ANAs), T cell hyper- activity, and elevated CD4/CD8 ...heightened T cell expansion in vitro, and in vivo, following antigen ...continued T cell expansion was noted even ...
11
Cell cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
... of T cells, and much of the resulting tissue destruction is a consequence of the resulting pro-inflammatory cytokine ...reduce T cell activation by the blocking of upstream events, ...
5
The Immunomodulatory Effect of Cyclophosphamide on Regulation of T -Cell Subsets and Antigen Presenting Cells
... The aim of the present study was to obtain further insight into these possible differentiation mechanisms, by studying the effect of CYP on antigen presenting cell[r] ...
14
Optimizing the process of nucleofection for professional antigen presenting cells
... monocyte cell line THP- 1. Although they only present nucleofection of this cell line with one program, the process was analyzed for plas- mid DNA and siRNA ...
7
Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response
... DC-like CD11c + microglia with neurogenic potential were induced by glatiramer acetate in a transgenic mouse model for Alzheimer’s disease [25]. Other descriptions of phenotypically DC-like microglia in CNS have not ...
9
Antigen-specific CD8 þ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
... the T EM cells are the majority of the population of CTLs in models of both antitumour immunity and ...level, antigen-specific T EM cells induced much higher IL-1b levels in APCs than ...
Innate Immune Responses in Fish: Antigen Presenting Cells and Professional Phagocytes
... B cells in mammals are composed of different subsets with different functions and locations; B-2 cells (or follicular B cells), B-1 cells, and marginal zone (MZ) B cells (Zhang, ...B-2 ...
17
Maintenance of antigen specificity by human interleukin 2 dependent T cell lines Use of antigen presenting cells and OKT3 antibody in the absence of antigen
... of T cells obtained from localized anatomic sites of pathology may offer a new approach to the investigation of certain human autoimmune ...interleukin-2-dependent T cell cloning is to be ...
11
Utilisation of an in vitro T-cell priming assay to characterise the effects of co-inhibitory signalling on the activation of antigen-specific T-cells.
... drug antigen (SMX-NO)-specific activation of ...enhanced T-cell activation seen with PD-L1-block ...of antigen-stimulated naïve, but also memory T-cells, suggesting a greater ...
333
Resident lung antigen presenting cells have the capacity to promote Th2 T cell differentiation in situ
... USA Antigen exposure via airway epithelia is often associated with a failure to prime or with the preferen- tial priming of Th2 ...pulmonary T cell priming is induced, the lung ...
9
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
... cient cells by virtue of its ability to reorganize the il4 (Figure 2A) and, indeed, promote Th2 differentiation locus and antagonize Th1-promoting pathways (Murphy (Langenkamp et ...type T cells by ...
12
Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent
... malignant cells suggests that the anti-tumour immune response is being attenuated limiting competent immune surveillance (reviewed in ...regulatory cell types, focus has shifted towards cellular mediated ...
10
Dendritic Cell Migration Limits the Duration of CD8+ T-Cell Priming to Peripheral Viral Antigen
... ⴙ T cells (T CD8 ⴙ ) play a crucial role in immunity to ...Antiviral T CD8 ⴙ are initially activated by recognition of major histocompatibility complex (MHC) class I-peptide complexes on the ...
9
Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross priming and tumor regression in mice
... + T cell response induced by activated pDC injection was directed against multiple tumor-associated antigens, as we detected relatively robust CTL responses not only against a neo-antigen, OVA, but ...
12
Antigen-presenting cells of the gastrointestinal tract
... (A number of other investigators have indirectly compared dendritic cells from different tissues. For example, liver dendritic cell-enriched populations were found to have[r] ...
285
The role of antigen presenting cells in the induction of HIV 1 latency in resting CD4+ T cells
... non-inducing antigen presenting ...of antigen presenting cell (APC) subpopulations that could induce latency (CD1c + , SLAN + , CD14 + monocytes) in non-proliferating CD4 + ...
16
Targeting of antigen presenting cells with mannosylated conjugates
... of antigen processing and presentation, which are a necessity for an adequate adaptive immune ...an antigen can enhance antigen presentation while DC maturation via the TLR- ligands is ...and ...
205
Theileria annulata-transformed cell lines are efficient antigen-presenting cells for in vitro analysis of CD8 T cell responses to bovine herpesvirus-1
... growing cell lines infected with the protozoan parasite Theileria annulata can readily be established by in vitro infection of leukocytes with the sporozoite stage of the ...transformed cell lines could be ...
12