T regulatory cells
Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease
... In our study, we observed elevated levels of the surface expression of these molecules on the Treg population com- pared to those of other CD4 ⫹ T cells, regardless of HIV infection status (Fig. 3). We also ...
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Regulatory T cells in multiple sclerosis and myasthenia gravis
... by T lymphocytes with specificity to neuronal antigens in genetically susceptible ...in T regulatory cells ...CD4+ T cell subsets that mediate autoimmune ...by T effectors have ...
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The role of regulatory T cells in cancer immunology
... immune cells. Abbreviations: Treg, T regulatory cells; TME, tumor microenvironment; iTreg, inducible Treg; Teff, T effector cells; IL, interleukin; ADO, adenosine; TGF-β, ...
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Role of CD8+ regulatory T cells in organ transplantation
... recent emergence of composite tissue transplantation, which is the treatment of choice for patients suffering from severe burns and trauma, presents new challenges and opportunities for long-term transplant survival ...
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Memory regulatory T cells reside in human skin
... of cells purified from peripheral tissue in ...other T cell populations in skin ...cutaneous T cell ...tissue-resident cells as a result of a variety of essential functions they play within ...
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Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells
... B cells have been shown to have a role in the fine equilibrium for immune ...B cells might contribute to immune modulation ...B cells in oral tolerance has been inves- tigated because ...
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Harnessing FOXP3+ regulatory T cells for transplantation tolerance
... Given the limited repertoire of licensed drugs, induction strat- egies based on lymphocyte depletion provide immediate oppor- tunities. The major disadvantage of lymphocyte depletion is the homeostatic expansion of host ...
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Regulatory T cells: friend or foe in immunity to infection
... innate cells, including macrophages and ...innate cells, promote the induction of Th2 ...Tr cells and from innate cells inhibit the activation of Th1 cells, which mediate immunity to ...
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Natural killer cells and regulatory T cells in early pregnancy loss
... immune cells that predominantly populate the pregnant uterus are natural killer (NK) ...these cells are not killers, but rather provide a microenviron- ment that is pregnancy compatible and supports healthy ...
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Imbalance of Th17 Cells and Regulatory T Cells in Tuberculous Pleural Effusion
... of T-helper type 1 (Th1) or Th2 lineage more than 2 decades ago, regulatory T cells (Tregs), and T helper interleukin 17 (IL-17)-producing cells (Th17 cells) have been ...
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Natural Regulatory T Cells and Persistent Viral Infection
... these cells during infection ...naı¨ve T cells into effector T cells is controlled by DC, which present processed antigenic peptides to T ...Th cells upon antigen ...
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Regulatory T cells and control of the germinal centre response
... + cells lack interferon regu- latory factor (IRF)4 develop spontaneous GCs but are not a phenocopy of Foxp3-deficient mice ...cytotoxic T-lymphocyte antigen 4 (CTLA-4), and changes in these molecules may ...
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<p>Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells</p>
... Cancer vaccines can be classi fi ed as whole-cell tumor vaccines, tumor protein (or peptide) vaccines, genetically engineered (tumor DNA or RNA) vaccines and monoclo- nal antibody tumor vaccines. Since the US Food and ...
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Nature of Regulatory T Cells in the Context of Allergic Disease
... peripheral T cells represents a key step in specific ...proliferative T-cell and Th1 (interferon-c) and Th2 (IL-5, IL-13) cytokine responses and increased IL- 10 and TGF-b secretion by ...
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Impaired survival of regulatory T cells in pulmonary sarcoidosis
... Fig. 4 Impaired survival of sarcoidosis Tregs. Isolated Tregs (purity >97 %) were cultured with recombinant human IL-2. a Percentage alive Tregs at 72 hours of culture. Horizontal line indicates the median. ...
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Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis
... extracts for 8 weeks. Significant erythema and crusts were observed after 3 weeks of D. farinae application. After 6 weeks of application, the most se- vere erythema, crusts, excoriation, and oozing were apparent. (B) ...
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Unravelling the Functions of Regulatory T Cells during Infection
... However, not all studies have revealed that Treg function to control effector activation. Paradoxically, it has been shown that Treg provide protective re- sponses in some pathogen infections permitting timely entry of ...
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Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
... tor T-bet and IL-12Rβ2 chain which is essential for responding to IL-12 and the differentiation of a Th1 phenotype [61, 62, ...CD8+ T cells [66]. IL-27 can enhance the proliferation of naïve CD8+ ...
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CD4+ T Cells Develop Antiretroviral Cytotoxic Activity in the Absence of Regulatory T Cells and CD8+ T Cells
... ⫹ T cells on CD4 ⫹ T cell cytotoxicity is also not understood, but similar findings were made in CD8-depleted, simian immunodeficiency virus (SIV)- infected macaques, where GzmB-expressing CD4 ⫹ ...
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Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs
... immature T cell lineage into a regulatory pathway during positive selection on high affinity T cell receptor ligands ...the T cell receptor, activated Tregs can exert non-antigen specific ...
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