Tandem Mass Spectrometric
A Validated Liquid Chromatography–Tandem Mass Spectrometric (LC-MS/MS) Method for the Estimation of Fulvestrant in Human Plasma
... / tandem mass spectrometric assay (LC-MS/MS) was developed to quantify fulvestrant in human plasma using fulvestrant-D3 as an internal standard ...spray tandem mass spectrometry ...
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High Throughput Liquid Chromatography – Tandem Mass Spectrometric Method for Simultaneous Quantification of Carvedilol and Its Metabolite 4 Hydroxyphenyl Carvedilol in Human Plasma and Its Application to Bioequivalence Study
... A simple, sensitive and reliable method is described for simultaneous quantification of Carvedilol and its metabolite 4-Hydroxyphenyl Carvedilol in human plasma by using High-throughput liquid ...
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Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds
... dissociation tandem mass spectrometric analysis (CID-MS/MS) showed the characteristic losses of water, carbonmonoxide and propene molecules, while analysis in negative ion mode showed the ...
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TANDEM MASS SPECTROMETRIC INVESTIGATIONS ON SELENOCUMULENES AND NON-NATURAL AMINO ACID HYBRID PEPTIDES: DIFFERENTIATION OF ISOMERS OF THE PEPTIDES AND SOME AROMATIC SULFONIC ACIDS
... Neutralization–reionization mass spectrometry (NRMS) has proven to be a successful and versatile technique for the generation and characterization of several elusive molecules in the gas ...
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A SENSITIVE LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRIC ASSAY FOR THE DETERMINATION OF ARTEMETHER AND ITS ACTIVE METABOLITE DIHYDROARTEMISININ IN HUMAN PLASMA
... development, mass parameters were tuned in positive and negative ionization modes using electrospray ionization source for the analytes and the IS at a concentration of 100 ng/mL tuning ...
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DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIC METHOD FOR SIMULTANEOUS QUANTIFICATION OF TELMISARTIN IN HUMAN PLASMA
... chromatography/tandem mass spectrometry (LC/MS/MS) method developed and validated for the quantification of Telmisartan in human plasma with simple single-step extraction method, minimum run time for ...
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Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of lenalidomide in human plasma and its application on bioequivalence studies
... formic acid in water-methanol in the ratio of (15:85, v/v) at a flow rate of 0.5 mL/min. Protonated ions formed by electrospray ionization in the positive mode were used to detect analyte and fluconazole (internal ...
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Quantification of ursodeoxy cholic acid in human plasma by using high performance liquid chromatography–tandem mass spectrometric method and its applications in pharmacokinetics
... A sensitive and selective method is described for the quantification of Ursodeoxy cholic acid in human plasma using Diclofenac as internal standard. The Bioanalytical approach consists of Precipitation with Acetonitrile, ...
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Method Development and Validation for the Quantification of Acrylamide in Potato Chips and Other Locally Available Food by LC MS/MS in Bangladesh
... and Tandem mass spectrometric (LC-MS/MS) analytical method was developed for the quantification of acrylamide in potato chips, a probable carcinogenic and neurotoxic compound in fried food ...
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Sensitive LC MS/MS Method for the Simultaneous Determination of Bisoprolol and Triamterene in human plasma
... elution. The linearity range for bisoprolol in plasma was found to be 0.05-120 ng/ml. Total run time for this analysis was 5.0 minutes [1]. Similarly, Bhatt et al. reported the determination of bisoprolol in human plasma ...
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Development and Validation of LC-MS/MS Method for the Analysis of P-Toluenesulfonicacid, In Antiviral Drug Acyclovir
... chromatographic-tandem mass spectrometric (LC/MS/MS) method was developed and validated for the trace analysis (>1 ppm level) of p-Toluenesulfonicacid, a genotoxic impurity, in acyclovir drug ...
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A Selective and Sensitive Method Development and Validation by LC-MS/MS Approach for Trace Level Quantification of Potential Genotoxic Impurities of ERL Ethyl Ester and ERL Nitro Compound in Erlotinib Hydrochloride Drug Substance
... with tandem mass spectrometric (LC-MS/MS) method was developed and validated for the trace analysis of ethyl 2-amino-4,5-bis(2- methoxyethoxy)benzoate (ERL ethyl ester) and ethyl ...
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DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF IRBESARTAN AND HYDROCHLOROTHIAZIDE IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
... chromatographic-tandem mass spectrometric (LC- MS/MS) method for the simultaneous estimation of Irbesartan (IRB) and hydrochlorothiazide (HCTZ) in human plasma using liquid-liquid extraction ...
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Modern mass spectrometric techniques applied to occupational hygiene analysis
... Figure 4 shows mass chromatograms o f a swab sample taken during occupational hygiene monitoring o f a worker spraying a product known to contain BAC. The sampling procedures and guidance on occupational hygiene ...
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Label-free data standardization for clinical metabolomics
... Fig 1 The concept for label-free standardization of metabolomics data. The actual concentrations of substances in the blood plasma sample cover several orders of magnitude (a). When the substances are plotted according ...
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Missed by Newborn Screening Using Tandem Mass
... Screening for Citrin Deficiency Based on Citrulline Values and Relative Increases. 150[r] ...
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Analysis of dynamic tyrosine phosphoproteome in LFA 1 triggered migrating T cells
... in mass spectrometric technology in the past few years has allowed analysis and identification of proteins undergoing such post- translational modifications with unprecedented levels of ...with ...
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Targeted quantitative mass spectrometric immunoassay for human protein variants
... the data in column 1, and the performance of the assay verified with the control sample. The concentrations of cystatin C and its variants were then individually deter- mined, averaged (from the two analyses for each ...
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Mass spectrometric studies of ionization in shock heated gas mixtures
... 2.. Arrangement of accelerating slits. x-t diagram near end wall. Arrhenius plot of argon ions. Arrhenius plot of hydrogen ions.. The predominant impurity ions can be found a[r] ...
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Mass Spectrometric Analysis of Organic Aerosol Composition: Laboratory and Ambient
... Chemical characterization of particle–phase products in the chamber samples can suggest possible chemical tracers for SOA formation from β–caryophyllene in ambient aerosol. Fine ambient aerosol collected in downtown ...
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