TBX1 gene
TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid
... of Tbx1. Similarly, perturbation of RA levels downregulate Tbx1 expression in the avian embryo (Roberts et ...of Tbx1 during pharyngeal arch ...of Tbx1 were predominantly downregulated during ...
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The T box gene family: emerging roles in development, stem cells and cancer
... amphioxus gene generally corresponds to two, or sometimes three, vertebrate genes (Dehal and Boore, 2005; Ruvinsky et ...amphioxus gene, AmphiTbx1/10, corresponds to two vertebrate genes, Tbx1 and ...
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β catenin deficiency causes DiGeorge syndrome like phenotypes through regulation of Tbx1
... or Tbx1 genetic background, ectopic activation of Wnt– b -catenin signaling caused an increased incidence and severity of DGS- like ...the gene dosage of Fgf8 rescued pharyngeal arch artery defects caused ...
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Analysis of TBX1 Variation in Patients with Psychotic and Affective Disorders
... responsible gene/s are assumed to also play a significant role in the etiology of nonsyndromic psychiatric ...the TBX1 gene has been shown to be sufficient to cause the core physical malformations ...
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Original Article Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin
... (Tbx1) gene is closely involved in embryonic kidney ...of Tbx1 in acute kidney injury (AKI) and the underlying mechanism, we detected the expression of Tbx1 and components of transforming ...
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Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development
... The Tbx1 gene is turned on at approximately E8 in the paraxial mesoderm, and in the adjacent ectoderm and endoderm ...that Tbx1 interacts with and may directly regulate Fgf8 gene expression ...
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Tbx1 is expressed at multiple sites of epithelial mesenchymal interaction during early development of the facial complex
... ABSTRACT TBX1 encodes a T-box-containing transcription factor, which is thought to be a key player in the aetiology of the DiGeorge and Velocardiofacial syndromes ...murine Tbx1 during early facial ...
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Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis
... Ectopic TBX1 expression does not reverse thymus fate By ...ectopic Tbx1 cannot reverse thymus fate after it is established, as Foxn1 Cre is expressed in 3rd pp cells that are already committed to a thymus ...
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Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear
... bHLH gene is expressed after Neurog1 in the inner ear, suggesting that the latter acts as a determination gene and the former as a differentiation gene (Ma et ...
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Arid3b is essential for second heart field cell deployment and heart patterning
... (Fgf8, Tbx1, Shh) was also normal in Arid3b mutants, suggesting that they are not responsible for the cardiac ...this gene has been shown to alter cell adhesion and cell motility (Zhang et ...
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Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice
... mouse displaying normal anterior (AC) and posterior canals (PC), but truncation of the lateral canal (arrowhead). (C) Whi/+ mouse showing normal morphology of the anterior canal, truncation of the lateral canal, and some ...
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A Tbx1 Six1/Eya1 Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis
... Eya1 functionally interacts with Tbx1 in vivo. (A–D) Gross views of cardiovas- cular structures of newborn Eya1/Tbx1 compound mutants. Asterisk in C denotes interrupted aortic arches. (E–J) Whole- mount RNA ...
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Rewiring of an ancestral Tbx1/10 Ebf Mrf network for pharyngeal muscle specification in distinct embryonic lineages
... division, Tbx1/10 is activated in the anterior-most aTLC, the OSM founder cell (OSMF) (C ′ ) and is maintained in both daughter cells, the OSM precursors (OSMP) (D ′ ...with gene expression mapped on. Onset ...
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Towards gene network estimation with structure learning
... comparison, it is categorised into one of the three categories. The control value was set as the average expression level of the gene across experiments. To discretize the data, a threshold was set to the ratio ...
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Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation
... of gene SAMSN1 corresponded to the phenotype of individuals in this family ...SAMSN1 gene expression in TDS displayed a relatively low level like ADPKD ...
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BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation
... On the basis of our results, we propose the following model of Jag2 function in developing teeth (Fig. 9). During tooth initiation, a group of oral epithelial cells forms a population of dental cells with an as yet ...
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Nodal and Hedgehog synergize in gill slit formation during development of the cephalochordate Branchiostoma floridae
... The larval pharynx of the cephalochordate Branchiostoma (amphioxus) is asymmetrical. The mouth is on the left, and endostyle and gill slits are on the right. At the neurula, Nodal and Hedgehog (Hh) expression becomes ...
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Pitx2 promotes development of splanchnic mesoderm derived branchiomeric muscle
... factor Tbx1 is expressed in core cells of the branchial arches and is required for first branchial arch muscle development, although MyoR continues to be expressed in the Tbx1 mutants (Kelly et ...mutants, ...
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Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition
... of gene expression in head structures con- sidered morphologically non-homologous [58], the concept of heterotopy has been invoked, that is, the idea that hom- ologous structures can alter their position during ...
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Tissue specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
... expresses Tbx1 and Casr at ...2007). Tbx1 is a good candidate for mediating the effects of SHH on 3rd pp patterning because it is a known target of SHH signaling in pharyngeal arch mesoderm (Garg et ...Shh- ...
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